NMR Metabolomics in Serum Fingerprinting of Schizophrenia Patients in a Serbian Cohort
Аутори
Simić, KatarinaTodorović, Nina
Trifunović, Snežana S.
Miladinović, Zoran P.
Gavrilović, Aleksandra
Jovanović, Silvana
Avramović, Nataša
Gođevac, Dejan
Vujisić, Ljubodrag V.
Tešević, Vele
Tasić, Ljubica
Mandić, Boris
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Schizophrenia is a widespread mental disorder that leads to significant functional impairments and premature death. The state of the art indicates gaps in the understanding and diagnosis of this disease, but also the need for personalized and precise approaches to patients through customized medical treatment and reliable monitoring of treatment response. In order to fulfill existing gaps, the establishment of a universal set of disorder biomarkers is a necessary step. Metabolomic investigations of serum samples of Serbian patients with schizophrenia (51) and healthy controls (39), based on NMR analyses associated with chemometrics, led to the identification of 26 metabolites/biomarkers for this disorder. Principal component analysis (PCA) and orthogonal partial least squares discriminant analysis (OPLS-DA) models with prediction accuracies of 0.9718 and higher were accomplished during chemometric analysis. The established biomarker set includes aspartate/aspartic acid, lysine, 2-hydro...xybutyric acid, and acylglycerols, which are identified for the first time in schizophrenia serum samples by NMR experiments. The other 22 identified metabolites in the Serbian samples are in accordance with the previously established NMR-based serum biomarker sets of Brazilian and/or Chinese patient samples. Thirteen metabolites (lactate/lactic acid, threonine, leucine, isoleucine, valine, glutamine, asparagine, alanine, gamma-aminobutyric acid, choline, glucose, glycine and tyrosine) that are common for three different ethnic and geographic origins (Serbia, Brazil and China) could be a good start point for the setup of a universal NMR serum biomarker set for schizophrenia. © 2022 by the authors.
Кључне речи:
biomarkers / chemometrics / metabolomics / NMR / schizophrenia / serum metabolitesИзвор:
Metabolites, 2022, 12, 8, 707-Издавач:
- MDPI
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200168 (Универзитет у Београду, Хемијски факултет) (RS-200168)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200026 (Универзитет у Београду, Институт за хемију, технологију и металургију - ИХТМ) (RS-200026)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200051 (Институт за општу и физичку хемију, Београд) (RS-200051)
- Organisation for the Prohibition of Chemical Weapons (OPCW) (Project Account No: L/ICA/ICB-217652/18 and L/ICA/ICB-108/21).
Напомена:
- Supplementary material: https://cherry.chem.bg.ac.rs/handle/123456789/5619
Повезане информације:
DOI: 10.3390/metabo12080707
ISSN: 2218-1989
WoS: 00084547830000
Scopus: 2-s2.0-85137383612
Колекције
Институција/група
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Simić, Katarina AU - Todorović, Nina AU - Trifunović, Snežana S. AU - Miladinović, Zoran P. AU - Gavrilović, Aleksandra AU - Jovanović, Silvana AU - Avramović, Nataša AU - Gođevac, Dejan AU - Vujisić, Ljubodrag V. AU - Tešević, Vele AU - Tasić, Ljubica AU - Mandić, Boris PY - 2022 UR - http://cherry.chem.bg.ac.rs/handle/123456789/5613 AB - Schizophrenia is a widespread mental disorder that leads to significant functional impairments and premature death. The state of the art indicates gaps in the understanding and diagnosis of this disease, but also the need for personalized and precise approaches to patients through customized medical treatment and reliable monitoring of treatment response. In order to fulfill existing gaps, the establishment of a universal set of disorder biomarkers is a necessary step. Metabolomic investigations of serum samples of Serbian patients with schizophrenia (51) and healthy controls (39), based on NMR analyses associated with chemometrics, led to the identification of 26 metabolites/biomarkers for this disorder. Principal component analysis (PCA) and orthogonal partial least squares discriminant analysis (OPLS-DA) models with prediction accuracies of 0.9718 and higher were accomplished during chemometric analysis. The established biomarker set includes aspartate/aspartic acid, lysine, 2-hydroxybutyric acid, and acylglycerols, which are identified for the first time in schizophrenia serum samples by NMR experiments. The other 22 identified metabolites in the Serbian samples are in accordance with the previously established NMR-based serum biomarker sets of Brazilian and/or Chinese patient samples. Thirteen metabolites (lactate/lactic acid, threonine, leucine, isoleucine, valine, glutamine, asparagine, alanine, gamma-aminobutyric acid, choline, glucose, glycine and tyrosine) that are common for three different ethnic and geographic origins (Serbia, Brazil and China) could be a good start point for the setup of a universal NMR serum biomarker set for schizophrenia. © 2022 by the authors. PB - MDPI T2 - Metabolites T1 - NMR Metabolomics in Serum Fingerprinting of Schizophrenia Patients in a Serbian Cohort VL - 12 IS - 8 SP - 707 DO - 10.3390/metabo12080707 ER -
@article{ author = "Simić, Katarina and Todorović, Nina and Trifunović, Snežana S. and Miladinović, Zoran P. and Gavrilović, Aleksandra and Jovanović, Silvana and Avramović, Nataša and Gođevac, Dejan and Vujisić, Ljubodrag V. and Tešević, Vele and Tasić, Ljubica and Mandić, Boris", year = "2022", abstract = "Schizophrenia is a widespread mental disorder that leads to significant functional impairments and premature death. The state of the art indicates gaps in the understanding and diagnosis of this disease, but also the need for personalized and precise approaches to patients through customized medical treatment and reliable monitoring of treatment response. In order to fulfill existing gaps, the establishment of a universal set of disorder biomarkers is a necessary step. Metabolomic investigations of serum samples of Serbian patients with schizophrenia (51) and healthy controls (39), based on NMR analyses associated with chemometrics, led to the identification of 26 metabolites/biomarkers for this disorder. Principal component analysis (PCA) and orthogonal partial least squares discriminant analysis (OPLS-DA) models with prediction accuracies of 0.9718 and higher were accomplished during chemometric analysis. The established biomarker set includes aspartate/aspartic acid, lysine, 2-hydroxybutyric acid, and acylglycerols, which are identified for the first time in schizophrenia serum samples by NMR experiments. The other 22 identified metabolites in the Serbian samples are in accordance with the previously established NMR-based serum biomarker sets of Brazilian and/or Chinese patient samples. Thirteen metabolites (lactate/lactic acid, threonine, leucine, isoleucine, valine, glutamine, asparagine, alanine, gamma-aminobutyric acid, choline, glucose, glycine and tyrosine) that are common for three different ethnic and geographic origins (Serbia, Brazil and China) could be a good start point for the setup of a universal NMR serum biomarker set for schizophrenia. © 2022 by the authors.", publisher = "MDPI", journal = "Metabolites", title = "NMR Metabolomics in Serum Fingerprinting of Schizophrenia Patients in a Serbian Cohort", volume = "12", number = "8", pages = "707", doi = "10.3390/metabo12080707" }
Simić, K., Todorović, N., Trifunović, S. S., Miladinović, Z. P., Gavrilović, A., Jovanović, S., Avramović, N., Gođevac, D., Vujisić, L. V., Tešević, V., Tasić, L.,& Mandić, B.. (2022). NMR Metabolomics in Serum Fingerprinting of Schizophrenia Patients in a Serbian Cohort. in Metabolites MDPI., 12(8), 707. https://doi.org/10.3390/metabo12080707
Simić K, Todorović N, Trifunović SS, Miladinović ZP, Gavrilović A, Jovanović S, Avramović N, Gođevac D, Vujisić LV, Tešević V, Tasić L, Mandić B. NMR Metabolomics in Serum Fingerprinting of Schizophrenia Patients in a Serbian Cohort. in Metabolites. 2022;12(8):707. doi:10.3390/metabo12080707 .
Simić, Katarina, Todorović, Nina, Trifunović, Snežana S., Miladinović, Zoran P., Gavrilović, Aleksandra, Jovanović, Silvana, Avramović, Nataša, Gođevac, Dejan, Vujisić, Ljubodrag V., Tešević, Vele, Tasić, Ljubica, Mandić, Boris, "NMR Metabolomics in Serum Fingerprinting of Schizophrenia Patients in a Serbian Cohort" in Metabolites, 12, no. 8 (2022):707, https://doi.org/10.3390/metabo12080707 . .