Elemental profiling of human semen with confirmed normozoospermia: Baseline levels for 44 elements
Само за регистроване кориснике
2022
Аутори
Stojsavljević, AleksandarZečević, Nebojša
Mihailović, Mladen
Jagodić, Jovana
Đurđić, Slađana Z.
Perović, Milan
Manojlović, Dragan D.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Background: As a consequence of the progressive decline in human semen quality in recent decades, modern epidemiological investigations have identified several trace elements that could be responsible for this phenomenon. However, their levels in semen have not been clearly elucidated, particularly for elements present in ultra-trace levels. Methods: We aimed to determine the levels of 39 (ultra)trace elements and 5 macroelements in human semen samples with confirmed normozoospermia using ICP-based techniques. The research was amplified by analyzing blood samples from the same participants. Results: Among the analyzed (ultra)trace elements in semen samples, Zn is the most and Tm is the least prominent. Zn levels in semen are so high that Zn should be considered as a macroelement in this matrix. The levels of Zn, Rh, Sm, Re, Ir, Tl, Na, and Ca were significantly higher in semen, while the levels of Cu, As, Rb, Gd, Sb, Tb, Tm, Lu, K, and Fe were significantly higher in blood. Correlation... analysis of the levels of 44 individual elements in paired semen and blood samples revealed positive correlations between 43 of the elements, particularly for Tl and Pt. An exception was the negative correlation for Cu, which showed that its high level in semen is associated with a low level in blood and contrariwise. Conclusion: The reported data can be used as baseline levels/reference values for 44 elements in human semen. Furthermore, the findings of this study could be relevant for further consideration of male infertility.
Кључне речи:
Human semen and blood / (Ultra)trace elements / Macroelements / Baseline levels/reference valuesИзвор:
Journal of Trace Elements in Medicine and Biology, 2022, 74, 127081-Издавач:
- Elsevier
Финансирање / пројекти:
Напомена:
- Supplementary material for: https://cherry.chem.bg.ac.rs/handle/123456789/5630
Повезане информације:
Институција/група
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Stojsavljević, Aleksandar AU - Zečević, Nebojša AU - Mihailović, Mladen AU - Jagodić, Jovana AU - Đurđić, Slađana Z. AU - Perović, Milan AU - Manojlović, Dragan D. PY - 2022 UR - http://cherry.chem.bg.ac.rs/handle/123456789/5628 AB - Background: As a consequence of the progressive decline in human semen quality in recent decades, modern epidemiological investigations have identified several trace elements that could be responsible for this phenomenon. However, their levels in semen have not been clearly elucidated, particularly for elements present in ultra-trace levels. Methods: We aimed to determine the levels of 39 (ultra)trace elements and 5 macroelements in human semen samples with confirmed normozoospermia using ICP-based techniques. The research was amplified by analyzing blood samples from the same participants. Results: Among the analyzed (ultra)trace elements in semen samples, Zn is the most and Tm is the least prominent. Zn levels in semen are so high that Zn should be considered as a macroelement in this matrix. The levels of Zn, Rh, Sm, Re, Ir, Tl, Na, and Ca were significantly higher in semen, while the levels of Cu, As, Rb, Gd, Sb, Tb, Tm, Lu, K, and Fe were significantly higher in blood. Correlation analysis of the levels of 44 individual elements in paired semen and blood samples revealed positive correlations between 43 of the elements, particularly for Tl and Pt. An exception was the negative correlation for Cu, which showed that its high level in semen is associated with a low level in blood and contrariwise. Conclusion: The reported data can be used as baseline levels/reference values for 44 elements in human semen. Furthermore, the findings of this study could be relevant for further consideration of male infertility. PB - Elsevier T2 - Journal of Trace Elements in Medicine and Biology T1 - Elemental profiling of human semen with confirmed normozoospermia: Baseline levels for 44 elements VL - 74 SP - 127081 DO - 10.1016/j.jtemb.2022.127081 ER -
@article{ author = "Stojsavljević, Aleksandar and Zečević, Nebojša and Mihailović, Mladen and Jagodić, Jovana and Đurđić, Slađana Z. and Perović, Milan and Manojlović, Dragan D.", year = "2022", abstract = "Background: As a consequence of the progressive decline in human semen quality in recent decades, modern epidemiological investigations have identified several trace elements that could be responsible for this phenomenon. However, their levels in semen have not been clearly elucidated, particularly for elements present in ultra-trace levels. Methods: We aimed to determine the levels of 39 (ultra)trace elements and 5 macroelements in human semen samples with confirmed normozoospermia using ICP-based techniques. The research was amplified by analyzing blood samples from the same participants. Results: Among the analyzed (ultra)trace elements in semen samples, Zn is the most and Tm is the least prominent. Zn levels in semen are so high that Zn should be considered as a macroelement in this matrix. The levels of Zn, Rh, Sm, Re, Ir, Tl, Na, and Ca were significantly higher in semen, while the levels of Cu, As, Rb, Gd, Sb, Tb, Tm, Lu, K, and Fe were significantly higher in blood. Correlation analysis of the levels of 44 individual elements in paired semen and blood samples revealed positive correlations between 43 of the elements, particularly for Tl and Pt. An exception was the negative correlation for Cu, which showed that its high level in semen is associated with a low level in blood and contrariwise. Conclusion: The reported data can be used as baseline levels/reference values for 44 elements in human semen. Furthermore, the findings of this study could be relevant for further consideration of male infertility.", publisher = "Elsevier", journal = "Journal of Trace Elements in Medicine and Biology", title = "Elemental profiling of human semen with confirmed normozoospermia: Baseline levels for 44 elements", volume = "74", pages = "127081", doi = "10.1016/j.jtemb.2022.127081" }
Stojsavljević, A., Zečević, N., Mihailović, M., Jagodić, J., Đurđić, S. Z., Perović, M.,& Manojlović, D. D.. (2022). Elemental profiling of human semen with confirmed normozoospermia: Baseline levels for 44 elements. in Journal of Trace Elements in Medicine and Biology Elsevier., 74, 127081. https://doi.org/10.1016/j.jtemb.2022.127081
Stojsavljević A, Zečević N, Mihailović M, Jagodić J, Đurđić SZ, Perović M, Manojlović DD. Elemental profiling of human semen with confirmed normozoospermia: Baseline levels for 44 elements. in Journal of Trace Elements in Medicine and Biology. 2022;74:127081. doi:10.1016/j.jtemb.2022.127081 .
Stojsavljević, Aleksandar, Zečević, Nebojša, Mihailović, Mladen, Jagodić, Jovana, Đurđić, Slađana Z., Perović, Milan, Manojlović, Dragan D., "Elemental profiling of human semen with confirmed normozoospermia: Baseline levels for 44 elements" in Journal of Trace Elements in Medicine and Biology, 74 (2022):127081, https://doi.org/10.1016/j.jtemb.2022.127081 . .