Oxorhenium(V) complexes with N,O ligands – synthesis and biological studies
2023
Преузимање 🢃
Аутори
Petrović, TamaraGligorijević, Nevenka
Ferdinand, Belaj
Poljarević, Jelena
Mihajlović-Lalić, Ljiljana
Aranđelović, Sandra
Nikolić, Stefan
Grgurić-Šipka, Sanja
Конференцијски прилог (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Rhenium complexes merit particular attention in the area of metallodrug design due to
rhenium’s broad spectrum of oxidation states and consequently, the possibility to design
compounds of great structural diversity [1,2]. Thus, the synthesis, chemical characterization,
and antitumor activity in vitro of the six Re(V) complexes are described. Novel compounds
were obtained via reaction of [ReOCl3(PPh3)2] with corresponding ligands (pyridine-2-
carboxylic acid, 3-methylpyridine-2-carboxylic acid, 6-methylpyridine-2-carboxylic acid, 2,3-
pyridinedicarboxylic acid, 2,5-pyridinedicarboxylic acid, and 2,6-pyridinedicarboxylic acid) in
acetonitrile or dichloromethane/methanol at 78 °C for 3h. The complexes were fully
characterized using NMR, IR, MS, and elemental analysis. Results of X-ray diffraction analysis
for three of these compounds confirmed the proposed octahedral geometry with bidentate
coordinated ligands, via both oxygen and nitrogen atoms. The antiproliferative effect was...
determined by MTT assay. All complexes expressed moderate to low cytotoxic potential.
Complex with pyridine-2-carboxylic acid showed dose-dependent cytotoxic potential,
particularly toward triple-negative breast adenocarcinoma cells MDA-MB-231 and pancreatic
adenocarcinoma cells PANC-1. Drug combination studies in PANC-1 cells with that complex
and Verapamil hydrochloride (VRP) showed a slight arrest of the cell cycle in the S phase and
also increase its antiproliferative potential.
Извор:
16th International Symposium on Applied Bioinorganic Chemistry (16-ISABC), Ioannina, Greece, June 11-14, 2023, 2023, 241-241Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200168 (Универзитет у Београду, Хемијски факултет) (RS-MESTD-inst-2020-200168)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200288 (Иновациони центар Хемијског факултета у Београду доо) (RS-MESTD-inst-2020-200288)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200043 (Институт за онкологију и радиологију Србије, Београд) (RS-MESTD-inst-2020-200043)
Колекције
Институција/група
Hemijski fakultet / Faculty of ChemistryTY - CONF AU - Petrović, Tamara AU - Gligorijević, Nevenka AU - Ferdinand, Belaj AU - Poljarević, Jelena AU - Mihajlović-Lalić, Ljiljana AU - Aranđelović, Sandra AU - Nikolić, Stefan AU - Grgurić-Šipka, Sanja PY - 2023 UR - http://cherry.chem.bg.ac.rs/handle/123456789/5957 AB - Rhenium complexes merit particular attention in the area of metallodrug design due to rhenium’s broad spectrum of oxidation states and consequently, the possibility to design compounds of great structural diversity [1,2]. Thus, the synthesis, chemical characterization, and antitumor activity in vitro of the six Re(V) complexes are described. Novel compounds were obtained via reaction of [ReOCl3(PPh3)2] with corresponding ligands (pyridine-2- carboxylic acid, 3-methylpyridine-2-carboxylic acid, 6-methylpyridine-2-carboxylic acid, 2,3- pyridinedicarboxylic acid, 2,5-pyridinedicarboxylic acid, and 2,6-pyridinedicarboxylic acid) in acetonitrile or dichloromethane/methanol at 78 °C for 3h. The complexes were fully characterized using NMR, IR, MS, and elemental analysis. Results of X-ray diffraction analysis for three of these compounds confirmed the proposed octahedral geometry with bidentate coordinated ligands, via both oxygen and nitrogen atoms. The antiproliferative effect was determined by MTT assay. All complexes expressed moderate to low cytotoxic potential. Complex with pyridine-2-carboxylic acid showed dose-dependent cytotoxic potential, particularly toward triple-negative breast adenocarcinoma cells MDA-MB-231 and pancreatic adenocarcinoma cells PANC-1. Drug combination studies in PANC-1 cells with that complex and Verapamil hydrochloride (VRP) showed a slight arrest of the cell cycle in the S phase and also increase its antiproliferative potential. C3 - 16th International Symposium on Applied Bioinorganic Chemistry (16-ISABC), Ioannina, Greece, June 11-14, 2023 T1 - Oxorhenium(V) complexes with N,O ligands – synthesis and biological studies SP - 241 EP - 241 UR - https://hdl.handle.net/21.15107/rcub_cherry_5957 ER -
@conference{ author = "Petrović, Tamara and Gligorijević, Nevenka and Ferdinand, Belaj and Poljarević, Jelena and Mihajlović-Lalić, Ljiljana and Aranđelović, Sandra and Nikolić, Stefan and Grgurić-Šipka, Sanja", year = "2023", abstract = "Rhenium complexes merit particular attention in the area of metallodrug design due to rhenium’s broad spectrum of oxidation states and consequently, the possibility to design compounds of great structural diversity [1,2]. Thus, the synthesis, chemical characterization, and antitumor activity in vitro of the six Re(V) complexes are described. Novel compounds were obtained via reaction of [ReOCl3(PPh3)2] with corresponding ligands (pyridine-2- carboxylic acid, 3-methylpyridine-2-carboxylic acid, 6-methylpyridine-2-carboxylic acid, 2,3- pyridinedicarboxylic acid, 2,5-pyridinedicarboxylic acid, and 2,6-pyridinedicarboxylic acid) in acetonitrile or dichloromethane/methanol at 78 °C for 3h. The complexes were fully characterized using NMR, IR, MS, and elemental analysis. Results of X-ray diffraction analysis for three of these compounds confirmed the proposed octahedral geometry with bidentate coordinated ligands, via both oxygen and nitrogen atoms. The antiproliferative effect was determined by MTT assay. All complexes expressed moderate to low cytotoxic potential. Complex with pyridine-2-carboxylic acid showed dose-dependent cytotoxic potential, particularly toward triple-negative breast adenocarcinoma cells MDA-MB-231 and pancreatic adenocarcinoma cells PANC-1. Drug combination studies in PANC-1 cells with that complex and Verapamil hydrochloride (VRP) showed a slight arrest of the cell cycle in the S phase and also increase its antiproliferative potential.", journal = "16th International Symposium on Applied Bioinorganic Chemistry (16-ISABC), Ioannina, Greece, June 11-14, 2023", title = "Oxorhenium(V) complexes with N,O ligands – synthesis and biological studies", pages = "241-241", url = "https://hdl.handle.net/21.15107/rcub_cherry_5957" }
Petrović, T., Gligorijević, N., Ferdinand, B., Poljarević, J., Mihajlović-Lalić, L., Aranđelović, S., Nikolić, S.,& Grgurić-Šipka, S.. (2023). Oxorhenium(V) complexes with N,O ligands – synthesis and biological studies. in 16th International Symposium on Applied Bioinorganic Chemistry (16-ISABC), Ioannina, Greece, June 11-14, 2023, 241-241. https://hdl.handle.net/21.15107/rcub_cherry_5957
Petrović T, Gligorijević N, Ferdinand B, Poljarević J, Mihajlović-Lalić L, Aranđelović S, Nikolić S, Grgurić-Šipka S. Oxorhenium(V) complexes with N,O ligands – synthesis and biological studies. in 16th International Symposium on Applied Bioinorganic Chemistry (16-ISABC), Ioannina, Greece, June 11-14, 2023. 2023;:241-241. https://hdl.handle.net/21.15107/rcub_cherry_5957 .
Petrović, Tamara, Gligorijević, Nevenka, Ferdinand, Belaj, Poljarević, Jelena, Mihajlović-Lalić, Ljiljana, Aranđelović, Sandra, Nikolić, Stefan, Grgurić-Šipka, Sanja, "Oxorhenium(V) complexes with N,O ligands – synthesis and biological studies" in 16th International Symposium on Applied Bioinorganic Chemistry (16-ISABC), Ioannina, Greece, June 11-14, 2023 (2023):241-241, https://hdl.handle.net/21.15107/rcub_cherry_5957 .