Determination of ionization constants of selected monocarbohydrazone derivatives
Аутори
Mrđan, GoranaVerbić, Tatjana
Marković, Olivera S.
Matijević, Borko
Vaštag, Đenđi
Apostolov, Suzana
Конференцијски прилог (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Carbohydrazone derivatives represent a very significant class of compounds due to their wide biological activity. Ionization states of functional groups present in the molecule are of vital importance for understanding of the pharmacokinetic and pharmacodynamic properties of the newly synthesized com-pounds.
One of the physicochemical parameters, the ionization constant (pKa), can be used as a molecular descriptor in order to relate structure and activity of a com-pound, which may indicate further potential application of newly synthesized deri-vatives.
In this work, ionization constants of twenty monocarbohydrazone deriva-tives were determined using potentiometric method, in order to obtain information about their ionization states under certain conditions.
Кључне речи:
biological activity / ionization constants / monocarbohydrazo-nes / molecular descriptors / potentiometryИзвор:
XIII International Scientific Conference Contemporary Materials 2020 Programme and the Book of Abstracts, Banja Luka, 11th September, 2020, 2020, 50-50Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200125 (Универзитет у Новом Саду, Природно-математички факултет) (RS-MESTD-inst-2020-200125)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200026 (Универзитет у Београду, Институт за хемију, технологију и металургију - ИХТМ) (RS-MESTD-inst-2020-200026)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200168 (Универзитет у Београду, Хемијски факултет) (RS-MESTD-inst-2020-200168)
Колекције
Институција/група
Hemijski fakultet / Faculty of ChemistryTY - CONF AU - Mrđan, Gorana AU - Verbić, Tatjana AU - Marković, Olivera S. AU - Matijević, Borko AU - Vaštag, Đenđi AU - Apostolov, Suzana PY - 2020 UR - http://cherry.chem.bg.ac.rs/handle/123456789/5960 AB - Carbohydrazone derivatives represent a very significant class of compounds due to their wide biological activity. Ionization states of functional groups present in the molecule are of vital importance for understanding of the pharmacokinetic and pharmacodynamic properties of the newly synthesized com-pounds. One of the physicochemical parameters, the ionization constant (pKa), can be used as a molecular descriptor in order to relate structure and activity of a com-pound, which may indicate further potential application of newly synthesized deri-vatives. In this work, ionization constants of twenty monocarbohydrazone deriva-tives were determined using potentiometric method, in order to obtain information about their ionization states under certain conditions. C3 - XIII International Scientific Conference Contemporary Materials 2020 Programme and the Book of Abstracts, Banja Luka, 11th September, 2020 T1 - Determination of ionization constants of selected monocarbohydrazone derivatives SP - 50 EP - 50 UR - https://hdl.handle.net/21.15107/rcub_cherry_5960 ER -
@conference{ author = "Mrđan, Gorana and Verbić, Tatjana and Marković, Olivera S. and Matijević, Borko and Vaštag, Đenđi and Apostolov, Suzana", year = "2020", abstract = "Carbohydrazone derivatives represent a very significant class of compounds due to their wide biological activity. Ionization states of functional groups present in the molecule are of vital importance for understanding of the pharmacokinetic and pharmacodynamic properties of the newly synthesized com-pounds. One of the physicochemical parameters, the ionization constant (pKa), can be used as a molecular descriptor in order to relate structure and activity of a com-pound, which may indicate further potential application of newly synthesized deri-vatives. In this work, ionization constants of twenty monocarbohydrazone deriva-tives were determined using potentiometric method, in order to obtain information about their ionization states under certain conditions.", journal = "XIII International Scientific Conference Contemporary Materials 2020 Programme and the Book of Abstracts, Banja Luka, 11th September, 2020", title = "Determination of ionization constants of selected monocarbohydrazone derivatives", pages = "50-50", url = "https://hdl.handle.net/21.15107/rcub_cherry_5960" }
Mrđan, G., Verbić, T., Marković, O. S., Matijević, B., Vaštag, Đ.,& Apostolov, S.. (2020). Determination of ionization constants of selected monocarbohydrazone derivatives. in XIII International Scientific Conference Contemporary Materials 2020 Programme and the Book of Abstracts, Banja Luka, 11th September, 2020, 50-50. https://hdl.handle.net/21.15107/rcub_cherry_5960
Mrđan G, Verbić T, Marković OS, Matijević B, Vaštag Đ, Apostolov S. Determination of ionization constants of selected monocarbohydrazone derivatives. in XIII International Scientific Conference Contemporary Materials 2020 Programme and the Book of Abstracts, Banja Luka, 11th September, 2020. 2020;:50-50. https://hdl.handle.net/21.15107/rcub_cherry_5960 .
Mrđan, Gorana, Verbić, Tatjana, Marković, Olivera S., Matijević, Borko, Vaštag, Đenđi, Apostolov, Suzana, "Determination of ionization constants of selected monocarbohydrazone derivatives" in XIII International Scientific Conference Contemporary Materials 2020 Programme and the Book of Abstracts, Banja Luka, 11th September, 2020 (2020):50-50, https://hdl.handle.net/21.15107/rcub_cherry_5960 .