Zn(II) complexes with thyazolyl-hydrazones: structure, photophysical properties, and antiproliferative activity
Аутори
Araškov, JovanaVišnjevac, Aleksandar
Blagojević, Vladimir
Filipović, Nenad
Todorović, Tamara
Конференцијски прилог (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Netoksični kompleksi na bazi Zn(II) privlače pažnju kao obećavajući kandidati za različite primene. U ovom radu je sintetisano i strukturno okarakterisano šest kompleksa Zn(II) (1‒3-NO3 i 1‒3-Cl) sa tiazolil-hidrazonskim ligandima na bazi piridina, koji se razlikuju po prirodi supstituenata na periferiji liganda, tipu anjona i geometriji oko jona metala. Simetrični kompleksi 2-Cl i 3-Cl, gde se atomi cinka nalaze na osi rotacije 2, ne pokazuju fotofizička svojstva, za razliku od drugih sintetisanih asimetričnih kompleksa. Poreklo fotoluminiscentnih svojstava je razjašnjeno korišćenjem DFT i TD-DFT proračuna. Antiproliferativna aktivnost kompleksa je bila u nanomolarnom opsegu na nekim od ispitivanih ćelijskih linija raka. Ukupni rezultati ukazuju na to da kompleksi Zn(II) sa tiazoil-hidrazonima imaju značajan potencijal kao multifunkcionalni materijali.
Non-toxic Zn-based complexes are drawing attention as promising candidates for various applications. In this study we report six Zn(II) complexes (1‒3-NO3 and 1‒3-Cl) with pyridyl-based thiazolyl-hydrazone ligands, which differ in the nature of substituents at the ligands’ periphery, anion type, and geometry around the metal ion. The symmetrical complexes 2-Cl and 3-Cl, where zinc atoms are located at a two-fold axis, do not exhibit photophysical properties, unlike other synthetized asymmetrical complexes. The origin of photoluminescent properties have been elucidated using DFT and TD-DFT calculations. Antiproliferative activity of the complexes was in the nanomolar range on some of the investigated cancer cell lines. The overall results suggest that Zn(II) thiazoyl-hydrazone complexes have considerable potential as multifunctional materials.
Извор:
58th Meeting of the Serbian Chemical Society, Belgrade, Serbia, 9th-10th June, 2022. In: Book of Abstracts and Proceedings, 2022Издавач:
- Belgrade : Serbian Chemical Society
Колекције
Институција/група
Hemijski fakultet / Faculty of ChemistryTY - CONF AU - Araškov, Jovana AU - Višnjevac, Aleksandar AU - Blagojević, Vladimir AU - Filipović, Nenad AU - Todorović, Tamara PY - 2022 UR - http://cherry.chem.bg.ac.rs/handle/123456789/6003 AB - Netoksični kompleksi na bazi Zn(II) privlače pažnju kao obećavajući kandidati za različite primene. U ovom radu je sintetisano i strukturno okarakterisano šest kompleksa Zn(II) (1‒3-NO3 i 1‒3-Cl) sa tiazolil-hidrazonskim ligandima na bazi piridina, koji se razlikuju po prirodi supstituenata na periferiji liganda, tipu anjona i geometriji oko jona metala. Simetrični kompleksi 2-Cl i 3-Cl, gde se atomi cinka nalaze na osi rotacije 2, ne pokazuju fotofizička svojstva, za razliku od drugih sintetisanih asimetričnih kompleksa. Poreklo fotoluminiscentnih svojstava je razjašnjeno korišćenjem DFT i TD-DFT proračuna. Antiproliferativna aktivnost kompleksa je bila u nanomolarnom opsegu na nekim od ispitivanih ćelijskih linija raka. Ukupni rezultati ukazuju na to da kompleksi Zn(II) sa tiazoil-hidrazonima imaju značajan potencijal kao multifunkcionalni materijali. AB - Non-toxic Zn-based complexes are drawing attention as promising candidates for various applications. In this study we report six Zn(II) complexes (1‒3-NO3 and 1‒3-Cl) with pyridyl-based thiazolyl-hydrazone ligands, which differ in the nature of substituents at the ligands’ periphery, anion type, and geometry around the metal ion. The symmetrical complexes 2-Cl and 3-Cl, where zinc atoms are located at a two-fold axis, do not exhibit photophysical properties, unlike other synthetized asymmetrical complexes. The origin of photoluminescent properties have been elucidated using DFT and TD-DFT calculations. Antiproliferative activity of the complexes was in the nanomolar range on some of the investigated cancer cell lines. The overall results suggest that Zn(II) thiazoyl-hydrazone complexes have considerable potential as multifunctional materials. PB - Belgrade : Serbian Chemical Society C3 - 58th Meeting of the Serbian Chemical Society, Belgrade, Serbia, 9th-10th June, 2022. In: Book of Abstracts and Proceedings T1 - Zn(II) complexes with thyazolyl-hydrazones: structure, photophysical properties, and antiproliferative activity UR - https://hdl.handle.net/21.15107/rcub_cherry_6003 ER -
@conference{ author = "Araškov, Jovana and Višnjevac, Aleksandar and Blagojević, Vladimir and Filipović, Nenad and Todorović, Tamara", year = "2022", abstract = "Netoksični kompleksi na bazi Zn(II) privlače pažnju kao obećavajući kandidati za različite primene. U ovom radu je sintetisano i strukturno okarakterisano šest kompleksa Zn(II) (1‒3-NO3 i 1‒3-Cl) sa tiazolil-hidrazonskim ligandima na bazi piridina, koji se razlikuju po prirodi supstituenata na periferiji liganda, tipu anjona i geometriji oko jona metala. Simetrični kompleksi 2-Cl i 3-Cl, gde se atomi cinka nalaze na osi rotacije 2, ne pokazuju fotofizička svojstva, za razliku od drugih sintetisanih asimetričnih kompleksa. Poreklo fotoluminiscentnih svojstava je razjašnjeno korišćenjem DFT i TD-DFT proračuna. Antiproliferativna aktivnost kompleksa je bila u nanomolarnom opsegu na nekim od ispitivanih ćelijskih linija raka. Ukupni rezultati ukazuju na to da kompleksi Zn(II) sa tiazoil-hidrazonima imaju značajan potencijal kao multifunkcionalni materijali., Non-toxic Zn-based complexes are drawing attention as promising candidates for various applications. In this study we report six Zn(II) complexes (1‒3-NO3 and 1‒3-Cl) with pyridyl-based thiazolyl-hydrazone ligands, which differ in the nature of substituents at the ligands’ periphery, anion type, and geometry around the metal ion. The symmetrical complexes 2-Cl and 3-Cl, where zinc atoms are located at a two-fold axis, do not exhibit photophysical properties, unlike other synthetized asymmetrical complexes. The origin of photoluminescent properties have been elucidated using DFT and TD-DFT calculations. Antiproliferative activity of the complexes was in the nanomolar range on some of the investigated cancer cell lines. The overall results suggest that Zn(II) thiazoyl-hydrazone complexes have considerable potential as multifunctional materials.", publisher = "Belgrade : Serbian Chemical Society", journal = "58th Meeting of the Serbian Chemical Society, Belgrade, Serbia, 9th-10th June, 2022. In: Book of Abstracts and Proceedings", title = "Zn(II) complexes with thyazolyl-hydrazones: structure, photophysical properties, and antiproliferative activity", url = "https://hdl.handle.net/21.15107/rcub_cherry_6003" }
Araškov, J., Višnjevac, A., Blagojević, V., Filipović, N.,& Todorović, T.. (2022). Zn(II) complexes with thyazolyl-hydrazones: structure, photophysical properties, and antiproliferative activity. in 58th Meeting of the Serbian Chemical Society, Belgrade, Serbia, 9th-10th June, 2022. In: Book of Abstracts and Proceedings Belgrade : Serbian Chemical Society.. https://hdl.handle.net/21.15107/rcub_cherry_6003
Araškov J, Višnjevac A, Blagojević V, Filipović N, Todorović T. Zn(II) complexes with thyazolyl-hydrazones: structure, photophysical properties, and antiproliferative activity. in 58th Meeting of the Serbian Chemical Society, Belgrade, Serbia, 9th-10th June, 2022. In: Book of Abstracts and Proceedings. 2022;. https://hdl.handle.net/21.15107/rcub_cherry_6003 .
Araškov, Jovana, Višnjevac, Aleksandar, Blagojević, Vladimir, Filipović, Nenad, Todorović, Tamara, "Zn(II) complexes with thyazolyl-hydrazones: structure, photophysical properties, and antiproliferative activity" in 58th Meeting of the Serbian Chemical Society, Belgrade, Serbia, 9th-10th June, 2022. In: Book of Abstracts and Proceedings (2022), https://hdl.handle.net/21.15107/rcub_cherry_6003 .