Lipophilicity of some guaianolides isolated from two endemic subspecies of Amphoricarpos neumayeri (Asteraceae) from Montenegro
Samo za registrovane korisnike
2009
Autori
Atrrog, Abubaker A. B.Natić, Maja
Tosti, Tomislav
Milojković-Opsenica, Dušanka
Đorđević, Iris
Tešević, Vele
Jadranin, Milka
Milosavljević, Slobodan M.
Lazić, Milan
Radulović, Siniša
Tešić, Živoslav Lj.
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
In this study 10 guaianolide-type sesquiterpene gamma-lactones named amphoricarpolides, isolated from the aerial parts of two endemic subspecies of Amphoricarpos neumayeri (ssp. neumayeri and ssp. murbeckii Bosnjak), were investigated by means of reversed-phase thin-layer chromatography. Methanol-water and tetrahydrofuran-water binary mixtures were used as mobile phase in order to determine lipophilicity parameters R(M)(0) and C(0). Some of the investigated compounds were screened for their cytotoxic activity against HeLa and B16 cells. Chromatographically obtained lipophilicity parameters were correlated with calculated logP values and IC(50) values. Principal component analysis identified the dominant pattern in the chromatographically obtained data. Copyright (C) 2008 John Wiley & Sons, Ltd.
Ključne reči:
guaianolides / reversed-phase thin-layer chromatography / lipophilicity / structure-activity relationship / PCAIzvor:
Biomedical Chromatography, 2009, 23, 3, 250-256Izdavač:
- John Wiley & Sons Ltd, Chichester
Finansiranje / projekti:
- Sinteza, analiza i aktivnost novih organskih polidentatnih liganada i njihovih kompleksa sa d-metalima (RS-MESTD-MPN2006-2010-142062)
DOI: 10.1002/bmc.1091
ISSN: 0269-3879
PubMed: 18816478
WoS: 000263776700003
Scopus: 2-s2.0-65249100236
Kolekcije
Institucija/grupa
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Atrrog, Abubaker A. B. AU - Natić, Maja AU - Tosti, Tomislav AU - Milojković-Opsenica, Dušanka AU - Đorđević, Iris AU - Tešević, Vele AU - Jadranin, Milka AU - Milosavljević, Slobodan M. AU - Lazić, Milan AU - Radulović, Siniša AU - Tešić, Živoslav Lj. PY - 2009 UR - https://cherry.chem.bg.ac.rs/handle/123456789/609 AB - In this study 10 guaianolide-type sesquiterpene gamma-lactones named amphoricarpolides, isolated from the aerial parts of two endemic subspecies of Amphoricarpos neumayeri (ssp. neumayeri and ssp. murbeckii Bosnjak), were investigated by means of reversed-phase thin-layer chromatography. Methanol-water and tetrahydrofuran-water binary mixtures were used as mobile phase in order to determine lipophilicity parameters R(M)(0) and C(0). Some of the investigated compounds were screened for their cytotoxic activity against HeLa and B16 cells. Chromatographically obtained lipophilicity parameters were correlated with calculated logP values and IC(50) values. Principal component analysis identified the dominant pattern in the chromatographically obtained data. Copyright (C) 2008 John Wiley & Sons, Ltd. PB - John Wiley & Sons Ltd, Chichester T2 - Biomedical Chromatography T1 - Lipophilicity of some guaianolides isolated from two endemic subspecies of Amphoricarpos neumayeri (Asteraceae) from Montenegro VL - 23 IS - 3 SP - 250 EP - 256 DO - 10.1002/bmc.1091 ER -
@article{ author = "Atrrog, Abubaker A. B. and Natić, Maja and Tosti, Tomislav and Milojković-Opsenica, Dušanka and Đorđević, Iris and Tešević, Vele and Jadranin, Milka and Milosavljević, Slobodan M. and Lazić, Milan and Radulović, Siniša and Tešić, Živoslav Lj.", year = "2009", abstract = "In this study 10 guaianolide-type sesquiterpene gamma-lactones named amphoricarpolides, isolated from the aerial parts of two endemic subspecies of Amphoricarpos neumayeri (ssp. neumayeri and ssp. murbeckii Bosnjak), were investigated by means of reversed-phase thin-layer chromatography. Methanol-water and tetrahydrofuran-water binary mixtures were used as mobile phase in order to determine lipophilicity parameters R(M)(0) and C(0). Some of the investigated compounds were screened for their cytotoxic activity against HeLa and B16 cells. Chromatographically obtained lipophilicity parameters were correlated with calculated logP values and IC(50) values. Principal component analysis identified the dominant pattern in the chromatographically obtained data. Copyright (C) 2008 John Wiley & Sons, Ltd.", publisher = "John Wiley & Sons Ltd, Chichester", journal = "Biomedical Chromatography", title = "Lipophilicity of some guaianolides isolated from two endemic subspecies of Amphoricarpos neumayeri (Asteraceae) from Montenegro", volume = "23", number = "3", pages = "250-256", doi = "10.1002/bmc.1091" }
Atrrog, A. A. B., Natić, M., Tosti, T., Milojković-Opsenica, D., Đorđević, I., Tešević, V., Jadranin, M., Milosavljević, S. M., Lazić, M., Radulović, S.,& Tešić, Ž. Lj.. (2009). Lipophilicity of some guaianolides isolated from two endemic subspecies of Amphoricarpos neumayeri (Asteraceae) from Montenegro. in Biomedical Chromatography John Wiley & Sons Ltd, Chichester., 23(3), 250-256. https://doi.org/10.1002/bmc.1091
Atrrog AAB, Natić M, Tosti T, Milojković-Opsenica D, Đorđević I, Tešević V, Jadranin M, Milosavljević SM, Lazić M, Radulović S, Tešić ŽL. Lipophilicity of some guaianolides isolated from two endemic subspecies of Amphoricarpos neumayeri (Asteraceae) from Montenegro. in Biomedical Chromatography. 2009;23(3):250-256. doi:10.1002/bmc.1091 .
Atrrog, Abubaker A. B., Natić, Maja, Tosti, Tomislav, Milojković-Opsenica, Dušanka, Đorđević, Iris, Tešević, Vele, Jadranin, Milka, Milosavljević, Slobodan M., Lazić, Milan, Radulović, Siniša, Tešić, Živoslav Lj., "Lipophilicity of some guaianolides isolated from two endemic subspecies of Amphoricarpos neumayeri (Asteraceae) from Montenegro" in Biomedical Chromatography, 23, no. 3 (2009):250-256, https://doi.org/10.1002/bmc.1091 . .