Synthesis, spectral characterization and electrochemical properties of 1H-3-(o-, m- and p-ferrocenylphenyl)-1-phenylpyrazole-4-carboxaldehydes
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Manojlović, Dragan D.
Joksović, Milan D.
Vukicevic, Rastko D.
Article (Published version)
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New ferrocene derivatives - 1H-1-phenylpyrazole-4-carboxaldehydes containing o-, m- and p- ferrocenylphenyl group at position 3 - were synthesized and characterized. The electrochemical investigation showed that the position of the ferrocenyl group does not affect the redox potential of these compounds. The X-ray crystal structure of the ortho-derivative is also presented. The screening for the in vitro antimicrobial activity against eleven bacterial and three fungal/yeast strains exhibited complete inactivity of these aldehydes, but n-butyl imines of ortho and meta derivatives showed moderate activity compared to those of the used standards. (C) 2009 Elsevier B.V. All rights reserved.
Keywords:Ferrocene-containing pyrazoles / Ferrocenylacetophenones / Vilsmeier-Haack reaction / Diazotation / Cyclic voltametry / Antimicrobial activity
Source:Journal of Organometallic Chemistry, 2009, 694, 9-10, 1575-1580
- Elsevier Science Sa, Lausanne