Phenolic profile and in vitro cytotoxic effects of selected herbs with potential skin anti-ageing properties
Апстракт
The latest studies show that UV and blue light, emitted by electronic devices with screens, slows the proliferation of the keratinocytes and generates free radicals leading to skin ageing1. Polyphenols, a compounds found in plants, can prevent light-induced damage to the skin. A constant screening of plant extracts is requisite in order to discern light-protective formulations to constitute cosmetic products. Using mass spectrometry, phenolic compounds were identified and quantified in plant extracts from 18 plants grown in Eastern Serbia. The cytotoxicity of the obtained extracts was tested on HaCaT cells (immortalized human keratinocytes) and IC50 values were determined. The obtained extracts are rich mixtures of phenolic compounds that must be dosed appropriately since they also damage skin cells at larger concentrations.
1. Nakashima Y, et al., Free Radic. Biol. Med. 2017, 108, 300–310.
Acknowledgment: This work was supported by The Science Fund of the Republic of Serbia, Ser...bian Science and Diaspora Collaboration Program, No.6389927, Ministry of Science, Technological Development and Innovation of Republic of Serbia Contract numbers 451-03-47/2023-01/200168 and 451-03-47/2023-01/200288.
Извор:
59th Meeting of the Serbian Chemical Society, Book of Abstracts, June 1-2, 2023, Novi Sad, Serbia, 2023, 41Колекције
Институција/група
Inovacioni centar / Innovation CentreTY - CONF AU - Ivković, Đurđa AU - Trifunović, Olga AU - Andrić, Filip AU - Krstić-Ristivojević, Maja AU - Ristivojević, Petar PY - 2023 UR - http://cherry.chem.bg.ac.rs/handle/123456789/6221 AB - The latest studies show that UV and blue light, emitted by electronic devices with screens, slows the proliferation of the keratinocytes and generates free radicals leading to skin ageing1. Polyphenols, a compounds found in plants, can prevent light-induced damage to the skin. A constant screening of plant extracts is requisite in order to discern light-protective formulations to constitute cosmetic products. Using mass spectrometry, phenolic compounds were identified and quantified in plant extracts from 18 plants grown in Eastern Serbia. The cytotoxicity of the obtained extracts was tested on HaCaT cells (immortalized human keratinocytes) and IC50 values were determined. The obtained extracts are rich mixtures of phenolic compounds that must be dosed appropriately since they also damage skin cells at larger concentrations. 1. Nakashima Y, et al., Free Radic. Biol. Med. 2017, 108, 300–310. Acknowledgment: This work was supported by The Science Fund of the Republic of Serbia, Serbian Science and Diaspora Collaboration Program, No.6389927, Ministry of Science, Technological Development and Innovation of Republic of Serbia Contract numbers 451-03-47/2023-01/200168 and 451-03-47/2023-01/200288. C3 - 59th Meeting of the Serbian Chemical Society, Book of Abstracts, June 1-2, 2023, Novi Sad, Serbia T1 - Phenolic profile and in vitro cytotoxic effects of selected herbs with potential skin anti-ageing properties IS - 41 UR - https://hdl.handle.net/21.15107/rcub_cherry_6221 ER -
@conference{ author = "Ivković, Đurđa and Trifunović, Olga and Andrić, Filip and Krstić-Ristivojević, Maja and Ristivojević, Petar", year = "2023", abstract = "The latest studies show that UV and blue light, emitted by electronic devices with screens, slows the proliferation of the keratinocytes and generates free radicals leading to skin ageing1. Polyphenols, a compounds found in plants, can prevent light-induced damage to the skin. A constant screening of plant extracts is requisite in order to discern light-protective formulations to constitute cosmetic products. Using mass spectrometry, phenolic compounds were identified and quantified in plant extracts from 18 plants grown in Eastern Serbia. The cytotoxicity of the obtained extracts was tested on HaCaT cells (immortalized human keratinocytes) and IC50 values were determined. The obtained extracts are rich mixtures of phenolic compounds that must be dosed appropriately since they also damage skin cells at larger concentrations. 1. Nakashima Y, et al., Free Radic. Biol. Med. 2017, 108, 300–310. Acknowledgment: This work was supported by The Science Fund of the Republic of Serbia, Serbian Science and Diaspora Collaboration Program, No.6389927, Ministry of Science, Technological Development and Innovation of Republic of Serbia Contract numbers 451-03-47/2023-01/200168 and 451-03-47/2023-01/200288.", journal = "59th Meeting of the Serbian Chemical Society, Book of Abstracts, June 1-2, 2023, Novi Sad, Serbia", title = "Phenolic profile and in vitro cytotoxic effects of selected herbs with potential skin anti-ageing properties", number = "41", url = "https://hdl.handle.net/21.15107/rcub_cherry_6221" }
Ivković, Đ., Trifunović, O., Andrić, F., Krstić-Ristivojević, M.,& Ristivojević, P.. (2023). Phenolic profile and in vitro cytotoxic effects of selected herbs with potential skin anti-ageing properties. in 59th Meeting of the Serbian Chemical Society, Book of Abstracts, June 1-2, 2023, Novi Sad, Serbia(41). https://hdl.handle.net/21.15107/rcub_cherry_6221
Ivković Đ, Trifunović O, Andrić F, Krstić-Ristivojević M, Ristivojević P. Phenolic profile and in vitro cytotoxic effects of selected herbs with potential skin anti-ageing properties. in 59th Meeting of the Serbian Chemical Society, Book of Abstracts, June 1-2, 2023, Novi Sad, Serbia. 2023;(41). https://hdl.handle.net/21.15107/rcub_cherry_6221 .
Ivković, Đurđa, Trifunović, Olga, Andrić, Filip, Krstić-Ristivojević, Maja, Ristivojević, Petar, "Phenolic profile and in vitro cytotoxic effects of selected herbs with potential skin anti-ageing properties" in 59th Meeting of the Serbian Chemical Society, Book of Abstracts, June 1-2, 2023, Novi Sad, Serbia, no. 41 (2023), https://hdl.handle.net/21.15107/rcub_cherry_6221 .