Anticancer Meroterpenoids from Centrapalus pauciflorus leaves: Chromone- and 2,4-Chromadione-Monoterpene Derivatives
Аутори
Krstić, Gordana B.Saidu, Muhammad Bello
Barta, Anita
Vágvölgyi, Máté
Ali, Hazhmat
Zupkó, István
Berkecz, Róbert
Gallah, Umar Shehu
Rédei, Dóra
Hohmann, Judit
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Eight previously undescribed chromones, named pauciflorins F–M and two 5-methyl-2,4-chromadione derivatives named as pauciflorins N and O, were isolated from the methanol extract of the leaves of Centrapalus pauciflorus (Willd.) H.Rob. together with the known (+)-spiro-ethuliacoumarin. The structures were determined via extensive spectroscopic analyses, including HRESIMS, 1D NMR (1H, 13C JMOD), and 2D NMR (HSQC, HMBC, 1H–1H COSY, and NOESY) experiments. Through an MTT assay, seven isolated compounds were tested for their antiproliferative properties against human adherent breast (MCF-7, MDA-MB-231), cervical (HeLa, SiHa), and ovarian (A2780) cancer cell lines. Pauciflorin F was effective against MCF-7 breast cancer cells, its activity (IC50 5.78 μM) was comparable to that of the reference agent cisplatin (IC50 5.78 μM).
Извор:
ACS Omega, 2023, 8, 34, 31389-31398Издавач:
- American Chemical Society
Финансирање / пројекти:
- Ministry of Innovation and Technology of Hungary
Колекције
Институција/група
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Krstić, Gordana B. AU - Saidu, Muhammad Bello AU - Barta, Anita AU - Vágvölgyi, Máté AU - Ali, Hazhmat AU - Zupkó, István AU - Berkecz, Róbert AU - Gallah, Umar Shehu AU - Rédei, Dóra AU - Hohmann, Judit PY - 2023 UR - http://cherry.chem.bg.ac.rs/handle/123456789/6330 AB - Eight previously undescribed chromones, named pauciflorins F–M and two 5-methyl-2,4-chromadione derivatives named as pauciflorins N and O, were isolated from the methanol extract of the leaves of Centrapalus pauciflorus (Willd.) H.Rob. together with the known (+)-spiro-ethuliacoumarin. The structures were determined via extensive spectroscopic analyses, including HRESIMS, 1D NMR (1H, 13C JMOD), and 2D NMR (HSQC, HMBC, 1H–1H COSY, and NOESY) experiments. Through an MTT assay, seven isolated compounds were tested for their antiproliferative properties against human adherent breast (MCF-7, MDA-MB-231), cervical (HeLa, SiHa), and ovarian (A2780) cancer cell lines. Pauciflorin F was effective against MCF-7 breast cancer cells, its activity (IC50 5.78 μM) was comparable to that of the reference agent cisplatin (IC50 5.78 μM). PB - American Chemical Society T2 - ACS Omega T1 - Anticancer Meroterpenoids from Centrapalus pauciflorus leaves: Chromone- and 2,4-Chromadione-Monoterpene Derivatives VL - 8 IS - 34 SP - 31389 EP - 31398 DO - 10.1021/acsomega.3c03884 ER -
@article{ author = "Krstić, Gordana B. and Saidu, Muhammad Bello and Barta, Anita and Vágvölgyi, Máté and Ali, Hazhmat and Zupkó, István and Berkecz, Róbert and Gallah, Umar Shehu and Rédei, Dóra and Hohmann, Judit", year = "2023", abstract = "Eight previously undescribed chromones, named pauciflorins F–M and two 5-methyl-2,4-chromadione derivatives named as pauciflorins N and O, were isolated from the methanol extract of the leaves of Centrapalus pauciflorus (Willd.) H.Rob. together with the known (+)-spiro-ethuliacoumarin. The structures were determined via extensive spectroscopic analyses, including HRESIMS, 1D NMR (1H, 13C JMOD), and 2D NMR (HSQC, HMBC, 1H–1H COSY, and NOESY) experiments. Through an MTT assay, seven isolated compounds were tested for their antiproliferative properties against human adherent breast (MCF-7, MDA-MB-231), cervical (HeLa, SiHa), and ovarian (A2780) cancer cell lines. Pauciflorin F was effective against MCF-7 breast cancer cells, its activity (IC50 5.78 μM) was comparable to that of the reference agent cisplatin (IC50 5.78 μM).", publisher = "American Chemical Society", journal = "ACS Omega", title = "Anticancer Meroterpenoids from Centrapalus pauciflorus leaves: Chromone- and 2,4-Chromadione-Monoterpene Derivatives", volume = "8", number = "34", pages = "31389-31398", doi = "10.1021/acsomega.3c03884" }
Krstić, G. B., Saidu, M. B., Barta, A., Vágvölgyi, M., Ali, H., Zupkó, I., Berkecz, R., Gallah, U. S., Rédei, D.,& Hohmann, J.. (2023). Anticancer Meroterpenoids from Centrapalus pauciflorus leaves: Chromone- and 2,4-Chromadione-Monoterpene Derivatives. in ACS Omega American Chemical Society., 8(34), 31389-31398. https://doi.org/10.1021/acsomega.3c03884
Krstić GB, Saidu MB, Barta A, Vágvölgyi M, Ali H, Zupkó I, Berkecz R, Gallah US, Rédei D, Hohmann J. Anticancer Meroterpenoids from Centrapalus pauciflorus leaves: Chromone- and 2,4-Chromadione-Monoterpene Derivatives. in ACS Omega. 2023;8(34):31389-31398. doi:10.1021/acsomega.3c03884 .
Krstić, Gordana B., Saidu, Muhammad Bello, Barta, Anita, Vágvölgyi, Máté, Ali, Hazhmat, Zupkó, István, Berkecz, Róbert, Gallah, Umar Shehu, Rédei, Dóra, Hohmann, Judit, "Anticancer Meroterpenoids from Centrapalus pauciflorus leaves: Chromone- and 2,4-Chromadione-Monoterpene Derivatives" in ACS Omega, 8, no. 34 (2023):31389-31398, https://doi.org/10.1021/acsomega.3c03884 . .