Binuclear azide-bridged hydrazone Cu(II) complex: Synthesis, characterization and evaluation of biological activity: Scientific paper
Аутори
Vitomirov, TeodoraČobeljić, Božidar
Pevec, Andrej
Radanović, Dušanka
Novaković, Irena T.
Savić, Milica
Anđelković, Katarina K.
Ristović, Maja Šumar
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The condensation product of 7-acetyl-6-azaindole and Girard’s T reagent ((E)-2-(2-(1-(1H-pyrrolo[2,3-c]pyridin-7-yl)ethylidene)hydrazineyl)-N,N,N-trimethyl-2-oxoethan-1-aminium, HL ligand) was used as a ligand in the reaction with Cu(BF4)2·6H2O and NaN3. The reaction led to the formation of a binuclear Cu(II) complex containing two end-to-end (di-m-1,3-N3) azide bridges, as well as two NNO-donor hydrazone ligands, forming an axially elongated square pyramidal geometry around each Cu(II) center. This end-to-end (di-m-1,3-N3) azide bridge binding mode has not yet been reported, in Cu(II) complexes containing the NNO-donor hydrazone ligands, which makes the structure of the complex even more interesting for further studies. The complex was characterized by elemental analysis, IR spectroscopy and X-ray crystallography, and it was found that it crystallizes in the triclinic space group P–1 with the asymmetric unit comprising one Cu(II) centre, zwitterionic ligand L, one azide (N3-) ligan...d and BF4- counter anion. Examination of antimicrobial activity of the complex shows higher antifungal and antibacterial activity towards tested Gram-positive bacteria in comparison to the hydrazone ligand, with the antifungal activity of the complex even being comparable to the activity of amphotericin B.
Кључне речи:
Girard’s T reagent / X-ray crystallography / antibacterial activity / anti-fungal activityИзвор:
Journal of the Serbian Chemical Society, 2023, 88, 9, 877-888Издавач:
- Serbian Chemical Society
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200026 (Универзитет у Београду, Институт за хемију, технологију и металургију - ИХТМ) (RS-MESTD-inst-2020-200026)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200168 (Универзитет у Београду, Хемијски факултет) (RS-MESTD-inst-2020-200168)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200288 (Иновациони центар Хемијског факултета у Београду доо) (RS-MESTD-inst-2020-200288)
- Science Fund of the Republic of Serbia, #7750288
- Tailoring Molecular Magnets and Catalysts Based on Transition Metal Complexes – TMMagCat
- e Slovenian Research Agency (ARRS), grant number P1-0175
Колекције
Институција/група
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Vitomirov, Teodora AU - Čobeljić, Božidar AU - Pevec, Andrej AU - Radanović, Dušanka AU - Novaković, Irena T. AU - Savić, Milica AU - Anđelković, Katarina K. AU - Ristović, Maja Šumar PY - 2023 UR - http://cherry.chem.bg.ac.rs/handle/123456789/6387 AB - The condensation product of 7-acetyl-6-azaindole and Girard’s T reagent ((E)-2-(2-(1-(1H-pyrrolo[2,3-c]pyridin-7-yl)ethylidene)hydrazineyl)-N,N,N-trimethyl-2-oxoethan-1-aminium, HL ligand) was used as a ligand in the reaction with Cu(BF4)2·6H2O and NaN3. The reaction led to the formation of a binuclear Cu(II) complex containing two end-to-end (di-m-1,3-N3) azide bridges, as well as two NNO-donor hydrazone ligands, forming an axially elongated square pyramidal geometry around each Cu(II) center. This end-to-end (di-m-1,3-N3) azide bridge binding mode has not yet been reported, in Cu(II) complexes containing the NNO-donor hydrazone ligands, which makes the structure of the complex even more interesting for further studies. The complex was characterized by elemental analysis, IR spectroscopy and X-ray crystallography, and it was found that it crystallizes in the triclinic space group P–1 with the asymmetric unit comprising one Cu(II) centre, zwitterionic ligand L, one azide (N3-) ligand and BF4- counter anion. Examination of antimicrobial activity of the complex shows higher antifungal and antibacterial activity towards tested Gram-positive bacteria in comparison to the hydrazone ligand, with the antifungal activity of the complex even being comparable to the activity of amphotericin B. PB - Serbian Chemical Society T2 - Journal of the Serbian Chemical Society T1 - Binuclear azide-bridged hydrazone Cu(II) complex: Synthesis, characterization and evaluation of biological activity: Scientific paper VL - 88 IS - 9 SP - 877 EP - 888 DO - 10.2298/JSC230623044V ER -
@article{ author = "Vitomirov, Teodora and Čobeljić, Božidar and Pevec, Andrej and Radanović, Dušanka and Novaković, Irena T. and Savić, Milica and Anđelković, Katarina K. and Ristović, Maja Šumar", year = "2023", abstract = "The condensation product of 7-acetyl-6-azaindole and Girard’s T reagent ((E)-2-(2-(1-(1H-pyrrolo[2,3-c]pyridin-7-yl)ethylidene)hydrazineyl)-N,N,N-trimethyl-2-oxoethan-1-aminium, HL ligand) was used as a ligand in the reaction with Cu(BF4)2·6H2O and NaN3. The reaction led to the formation of a binuclear Cu(II) complex containing two end-to-end (di-m-1,3-N3) azide bridges, as well as two NNO-donor hydrazone ligands, forming an axially elongated square pyramidal geometry around each Cu(II) center. This end-to-end (di-m-1,3-N3) azide bridge binding mode has not yet been reported, in Cu(II) complexes containing the NNO-donor hydrazone ligands, which makes the structure of the complex even more interesting for further studies. The complex was characterized by elemental analysis, IR spectroscopy and X-ray crystallography, and it was found that it crystallizes in the triclinic space group P–1 with the asymmetric unit comprising one Cu(II) centre, zwitterionic ligand L, one azide (N3-) ligand and BF4- counter anion. Examination of antimicrobial activity of the complex shows higher antifungal and antibacterial activity towards tested Gram-positive bacteria in comparison to the hydrazone ligand, with the antifungal activity of the complex even being comparable to the activity of amphotericin B.", publisher = "Serbian Chemical Society", journal = "Journal of the Serbian Chemical Society", title = "Binuclear azide-bridged hydrazone Cu(II) complex: Synthesis, characterization and evaluation of biological activity: Scientific paper", volume = "88", number = "9", pages = "877-888", doi = "10.2298/JSC230623044V" }
Vitomirov, T., Čobeljić, B., Pevec, A., Radanović, D., Novaković, I. T., Savić, M., Anđelković, K. K.,& Ristović, M. Š.. (2023). Binuclear azide-bridged hydrazone Cu(II) complex: Synthesis, characterization and evaluation of biological activity: Scientific paper. in Journal of the Serbian Chemical Society Serbian Chemical Society., 88(9), 877-888. https://doi.org/10.2298/JSC230623044V
Vitomirov T, Čobeljić B, Pevec A, Radanović D, Novaković IT, Savić M, Anđelković KK, Ristović MŠ. Binuclear azide-bridged hydrazone Cu(II) complex: Synthesis, characterization and evaluation of biological activity: Scientific paper. in Journal of the Serbian Chemical Society. 2023;88(9):877-888. doi:10.2298/JSC230623044V .
Vitomirov, Teodora, Čobeljić, Božidar, Pevec, Andrej, Radanović, Dušanka, Novaković, Irena T., Savić, Milica, Anđelković, Katarina K., Ristović, Maja Šumar, "Binuclear azide-bridged hydrazone Cu(II) complex: Synthesis, characterization and evaluation of biological activity: Scientific paper" in Journal of the Serbian Chemical Society, 88, no. 9 (2023):877-888, https://doi.org/10.2298/JSC230623044V . .