Untargeted Lipidomics Study of Bipolar Disorder Patients in Serbia
Аутори
Jadranin, MilkaAvramović, Nataša
Miladinović, Zoran P.
Gavrilović, Aleksandra
Tasic, Ljubica
Tešević, Vele
Mandić, Boris
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The Lipidomic profiles of serum samples from patients with bipolar disorder (BD) and healthy controls (C) were explored and compared. The sample cohort included 31 BD patients and 31 control individuals. An untargeted lipidomics study applying liquid chromatography (LC) coupled with high-resolution mass spectrometry (HRMS) was conducted to achieve the lipid profiles. Multivariate statistical analyses (principal component analysis and partial least squares discriminant analysis) were performed, and fifty-six differential lipids were confirmed in BD and controls. Our results pointed to alterations in lipid metabolism, including pathways of glycerophospholipids, sphingolipids, glycerolipids, and sterol lipids, in BD patient sera. This study emphasized the role of lipid pathways in BD, and comprehensive research using the LC-HRMS platform is necessary for future application in the diagnosis and improvement of BD treatments.
Кључне речи:
biomarkers / bipolar disorder / lipidomics / mass spectrometry / serumИзвор:
International Journal of Molecular Sciences, 2023, 24, 22, 16025-Издавач:
- MDPI
Финансирање / пројекти:
- Organisation for the Prohibition of Chemical Weapons (OPCW) (Grant Number: L/ICA/ICB-108/21)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200168 (Универзитет у Београду, Хемијски факултет) (RS-MESTD-inst-2020-200168)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200026 (Универзитет у Београду, Институт за хемију, технологију и металургију - ИХТМ) (RS-MESTD-inst-2020-200026)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200051 (Институт за општу и физичку хемију, Београд) (RS-MESTD-inst-2020-200051)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200110 (Универзитет у Београду, Медицински факултет) (RS-MESTD-inst-2020-200110)
Колекције
Институција/група
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Jadranin, Milka AU - Avramović, Nataša AU - Miladinović, Zoran P. AU - Gavrilović, Aleksandra AU - Tasic, Ljubica AU - Tešević, Vele AU - Mandić, Boris PY - 2023 UR - http://cherry.chem.bg.ac.rs/handle/123456789/6391 AB - The Lipidomic profiles of serum samples from patients with bipolar disorder (BD) and healthy controls (C) were explored and compared. The sample cohort included 31 BD patients and 31 control individuals. An untargeted lipidomics study applying liquid chromatography (LC) coupled with high-resolution mass spectrometry (HRMS) was conducted to achieve the lipid profiles. Multivariate statistical analyses (principal component analysis and partial least squares discriminant analysis) were performed, and fifty-six differential lipids were confirmed in BD and controls. Our results pointed to alterations in lipid metabolism, including pathways of glycerophospholipids, sphingolipids, glycerolipids, and sterol lipids, in BD patient sera. This study emphasized the role of lipid pathways in BD, and comprehensive research using the LC-HRMS platform is necessary for future application in the diagnosis and improvement of BD treatments. PB - MDPI T2 - International Journal of Molecular Sciences T1 - Untargeted Lipidomics Study of Bipolar Disorder Patients in Serbia VL - 24 IS - 22 SP - 16025 DO - 10.3390/ijms242216025 ER -
@article{ author = "Jadranin, Milka and Avramović, Nataša and Miladinović, Zoran P. and Gavrilović, Aleksandra and Tasic, Ljubica and Tešević, Vele and Mandić, Boris", year = "2023", abstract = "The Lipidomic profiles of serum samples from patients with bipolar disorder (BD) and healthy controls (C) were explored and compared. The sample cohort included 31 BD patients and 31 control individuals. An untargeted lipidomics study applying liquid chromatography (LC) coupled with high-resolution mass spectrometry (HRMS) was conducted to achieve the lipid profiles. Multivariate statistical analyses (principal component analysis and partial least squares discriminant analysis) were performed, and fifty-six differential lipids were confirmed in BD and controls. Our results pointed to alterations in lipid metabolism, including pathways of glycerophospholipids, sphingolipids, glycerolipids, and sterol lipids, in BD patient sera. This study emphasized the role of lipid pathways in BD, and comprehensive research using the LC-HRMS platform is necessary for future application in the diagnosis and improvement of BD treatments.", publisher = "MDPI", journal = "International Journal of Molecular Sciences", title = "Untargeted Lipidomics Study of Bipolar Disorder Patients in Serbia", volume = "24", number = "22", pages = "16025", doi = "10.3390/ijms242216025" }
Jadranin, M., Avramović, N., Miladinović, Z. P., Gavrilović, A., Tasic, L., Tešević, V.,& Mandić, B.. (2023). Untargeted Lipidomics Study of Bipolar Disorder Patients in Serbia. in International Journal of Molecular Sciences MDPI., 24(22), 16025. https://doi.org/10.3390/ijms242216025
Jadranin M, Avramović N, Miladinović ZP, Gavrilović A, Tasic L, Tešević V, Mandić B. Untargeted Lipidomics Study of Bipolar Disorder Patients in Serbia. in International Journal of Molecular Sciences. 2023;24(22):16025. doi:10.3390/ijms242216025 .
Jadranin, Milka, Avramović, Nataša, Miladinović, Zoran P., Gavrilović, Aleksandra, Tasic, Ljubica, Tešević, Vele, Mandić, Boris, "Untargeted Lipidomics Study of Bipolar Disorder Patients in Serbia" in International Journal of Molecular Sciences, 24, no. 22 (2023):16025, https://doi.org/10.3390/ijms242216025 . .