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Antimalarijska aktivnost derivata 7,8,15,16-tetraoksa-dispiro5.2.5.2heksadekan-3-karboksilne kiseline

dc.creatorOpsenica, Igor
dc.creatorTerzić-Jovanović, Nataša
dc.creatorOpsenica, Dejan M.
dc.creatorMilhous, WK
dc.creatorŠolaja, Bogdan A.
dc.date.accessioned2018-11-22T00:07:41Z
dc.date.available2018-11-22T00:07:41Z
dc.date.issued2004
dc.identifier.issn0352-5139
dc.identifier.urihttp://cherry.chem.bg.ac.rs/handle/123456789/680
dc.description.abstractSeveral C2 symmetrical mixed tetraoxanes were prepared starting from a gemdihydroperoxide and a ketone. The obtained tetraoxanes showed pronounced antimalarial activity against P falciparum chloroquine resistant W2 and chloroquine susceptible D6 strains, with N-(2-dimethylamino)ethyl-7,8,15,16-tetraoxa-dispiro[5.2.5.2]hexadecaric-3-carboxamide being as active as artermisinin.en
dc.description.abstractU ovom radu prikazana je sinteza serije C2 mešovitih tetraoksana polazeći od gem-dihidroperoksida cikloheksanona. Dobijenim derivatima ispitana je in vitro aktivnost prema W2 i D6 sojevima P. falciparum. Utvrđeno je da derivat N-(2-dimetilamino)etil 7,8,15,16-tetraoksa-dispiroŠ5.2.5.2Ćheksadekan-3-karboksamid pokazuje aktivnost vrlo blisku aktivnosti poznatog antimalarika artemizinina.sr
dc.publisherSerbian Chemical Soc, Belgrade
dc.rightsopenAccess
dc.sourceJournal of the Serbian Chemical Society
dc.subjectmixed tetraoxaneen
dc.subjectmalariaen
dc.subjectmalariaen
dc.subjectPlasmodium falciparumen
dc.subjectPlasmodium falciparumen
dc.subjectgem-dihydroperoxideen
dc.subjectgem-dihydroperoxideen
dc.title7,8,15,16-tetraoxa-dispiro[5.2.5.2]hexadecane-3-carboxylic acid derivatives and their antimalarial activityen
dc.titleAntimalarijska aktivnost derivata 7,8,15,16-tetraoksa-dispiro5.2.5.2heksadekan-3-karboksilne kiselinesr
dc.typearticle
dc.rights.licenseBY-NC-ND
dcterms.abstractТерзиц, Н; Милхоус, WК; Шолаја, Богдан A.; Опсеница, Д; Опсеница, Игор; Aнтималаријска активност деривата 7,8,15,16-тетраокса-диспиро5.2.5.2хексадекан-3-карбоксилне киселине; Aнтималаријска активност деривата 7,8,15,16-тетраокса-диспиро5.2.5.2хексадекан-3-карбоксилне киселине;
dc.citation.volume69
dc.citation.issue11
dc.citation.spage919
dc.citation.epage922
dc.identifier.wos000226120300011
dc.identifier.doi10.2298/JSC0411919O
dc.citation.other69(11): 919-922
dc.citation.rankM23
dc.type.versionpublishedVersion
dc.identifier.scopus2-s2.0-31544476296
dc.identifier.fulltexthttp://cherry.chem.bg.ac.rs/bitstream/id/9918/678.pdf
dc.identifier.rcubKon_1633


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