Stereoselective synthesis of alpha-hydroxy-beta-amino acids: the chiral pool approach
Апстракт
A method for the stereoselective homologation of alpha-amino acids into syn-alpha-hydroxy-beta-amino acids is described. based on the conversion of stereoisomeric cyanohydrins into trans-oxazolines. The synthetic potential of the method is illustrated in the enantioselective formal synthesis of Bestatin.
Кључне речи:
amino acids / cyanohydrins / bestatin / AHPA / oxazolineИзвор:
Journal of the Serbian Chemical Society, 2004, 69, 11, 981-990Издавач:
- Serbian Chemical Soc, Belgrade
DOI: 10.2298/JSC0411981T
ISSN: 0352-5139
WoS: 000226120300018
Scopus: 2-s2.0-24944448953
Колекције
Институција/група
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Tasic, G AU - Matović, Radomir AU - Saičić, Radomir PY - 2004 UR - https://cherry.chem.bg.ac.rs/handle/123456789/683 AB - A method for the stereoselective homologation of alpha-amino acids into syn-alpha-hydroxy-beta-amino acids is described. based on the conversion of stereoisomeric cyanohydrins into trans-oxazolines. The synthetic potential of the method is illustrated in the enantioselective formal synthesis of Bestatin. PB - Serbian Chemical Soc, Belgrade T2 - Journal of the Serbian Chemical Society T1 - Stereoselective synthesis of alpha-hydroxy-beta-amino acids: the chiral pool approach VL - 69 IS - 11 SP - 981 EP - 990 DO - 10.2298/JSC0411981T ER -
@article{ author = "Tasic, G and Matović, Radomir and Saičić, Radomir", year = "2004", abstract = "A method for the stereoselective homologation of alpha-amino acids into syn-alpha-hydroxy-beta-amino acids is described. based on the conversion of stereoisomeric cyanohydrins into trans-oxazolines. The synthetic potential of the method is illustrated in the enantioselective formal synthesis of Bestatin.", publisher = "Serbian Chemical Soc, Belgrade", journal = "Journal of the Serbian Chemical Society", title = "Stereoselective synthesis of alpha-hydroxy-beta-amino acids: the chiral pool approach", volume = "69", number = "11", pages = "981-990", doi = "10.2298/JSC0411981T" }
Tasic, G., Matović, R.,& Saičić, R.. (2004). Stereoselective synthesis of alpha-hydroxy-beta-amino acids: the chiral pool approach. in Journal of the Serbian Chemical Society Serbian Chemical Soc, Belgrade., 69(11), 981-990. https://doi.org/10.2298/JSC0411981T
Tasic G, Matović R, Saičić R. Stereoselective synthesis of alpha-hydroxy-beta-amino acids: the chiral pool approach. in Journal of the Serbian Chemical Society. 2004;69(11):981-990. doi:10.2298/JSC0411981T .
Tasic, G, Matović, Radomir, Saičić, Radomir, "Stereoselective synthesis of alpha-hydroxy-beta-amino acids: the chiral pool approach" in Journal of the Serbian Chemical Society, 69, no. 11 (2004):981-990, https://doi.org/10.2298/JSC0411981T . .