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dc.creatorAtanaskovic-Markovic, M
dc.creatorĆirković-Veličković, Tanja
dc.creatorGavrović-Jankulović, Marija
dc.creatorVuckovic, O
dc.creatorNestorovic, B
dc.date.accessioned2018-11-22T00:08:19Z
dc.date.available2018-11-22T00:08:19Z
dc.date.issued2005
dc.identifier.issn0905-6157
dc.identifier.urihttp://cherry.chem.bg.ac.rs/handle/123456789/704
dc.description.abstractPenicillins and cephalosporins are the most important betalactams inducing IgE-mediated reactions. The safety of administering cephalosporins to penicillin-allergic children is a particular problem, because cephalosporin allergenic determinants have not been properly identified. A study was undertaken to evaluate the frequency of anaphylactic reactions to cephalosporins and penicillins and their cross-reactivity in a pediatric population. A prospective survey was conducted in a group of 1170 children with suspected immediate allergic reactions to cephalosporins and/or penicillins, which were examined during a period of 8 yr. In vivo (skin tests and challenges) and in vitro tests (for specific IgE) were performed with standard concentration of penicillins and cephalosporins. When 1170 children with a clinical history of allergy to penicillins and/or cephalosporins were tested in vivo for immediate hypersensitivity to betalactams, 58.3% cases overall were found to be skin or challenge test positive. Among them, 94.4% patients were positive to penicillins and 35.3% to cephalosporins. The frequency of positive reactions in the in vivo testing was in the range from 36.4% to 88.1% for penicillins and from 0.3% to 29.2% for cephalosporins. However, 31.5% of the penicillin allergic children cross-reacted to some cephalosporin. If a child was allergic to a cephalosporin, the frequency of positive reactions to penicillin was 84.2%. The cross-reactivity between cephalosporins and penicillins varied between 0.3% and 23.9%. The cross-reactivity among different generations of cephalosporins varied between 0% and 68.8%, being the highest for first and second-generation cephalosporins and 0% for third generation cephalosporins. The frequency of immediate allergic reactions to cephalosporins is considerably lower compared to penicillins, and the degree of cross-reactivity between cephalosporins and penicillins depends on the generation of cephalosporins, being higher with earlier generation cephalosporins. The cross-reactivity among cephalosporins is lower compared to cross-reactivity between penicillins and cephalosporins.en
dc.publisherBlackwell Publishing, Oxford
dc.rightsrestrictedAccess
dc.sourcePediatric Allergy and Immunology
dc.subjectbetalactamsen
dc.subjectcephalosporinsen
dc.subjectchildrenen
dc.subjectcross-reactivityen
dc.subjectdrug allergyen
dc.subjectimmediate allergic reactionen
dc.subjectpenicillinsen
dc.titleImmediate allergic reactions to cephalosporins and penicillins and their cross-reactivity in childrenen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractНесторовиц, Б; Вуцковиц, О; Aтанасковиц-Марковиц, М; Ћирковић-Величковић, Тања; Гавровић-Јанкуловић, Марија;
dc.citation.volume16
dc.citation.issue4
dc.citation.spage341
dc.citation.epage347
dc.identifier.wos000229590200010
dc.identifier.doi10.1111/j.1399-3038.2005.00280.x
dc.citation.other16(4): 341-347
dc.citation.rankM21
dc.identifier.pmid15943598
dc.type.versionpublishedVersionen
dc.identifier.scopus2-s2.0-21044449657
dc.identifier.rcubKon_1657


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