Examination of the hydrophobicity of ACE inhibitors and their active metabolites by salting-out thin-layer chromatography
Apstrakt
The behavior of five ACE inhibitors and their active degradation products in salting-out thin-layer chromatography (SO TLC) has been examined on silica gel, cellulose, and polyacrylonitrile (PAN) with aqueous ammonium sulfate solutions of different concentration as mobile phases. It was found that increasing the concentration of the salt in the mobile phase led to increased R-M values for all the substances. Linear relationships were established between salt concentration and R-M values and regression data of the plots obtained were used to determine the lipophilicity R-M(0) and C-0. Lipophilicity determined in this way was correlated with calculated log P values. For comparison of these results with chromatographic behavior in conventional RP TLC, the examined substances were subjected to thin-layer chromatography on RP-18 silica gel with methanol-water mobile phases.
Ključne reči:
salting-out TLC / ACE inhibitors / silica gel / cellulose / polyacrylonitrile (PAN) adsorbent / RP-18 silicaIzvor:
Journal of Planar Chromatography: Modern TLC / Thin Layer Chromatography, 2005, 18, 102, 98-103Izdavač:
- Research Inst Medicinal Plants, Budakalasz
DOI: 10.1556/JPC.18.2005.2.2
ISSN: 0933-4173
WoS: 000229721000002
Scopus: 2-s2.0-20444417755
Kolekcije
Institucija/grupa
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Odovic, JV AU - Stojimirovic, BB AU - Aleksic, MB AU - Milojković-Opsenica, Dušanka AU - Tešić, Živoslav Lj. PY - 2005 UR - https://cherry.chem.bg.ac.rs/handle/123456789/706 AB - The behavior of five ACE inhibitors and their active degradation products in salting-out thin-layer chromatography (SO TLC) has been examined on silica gel, cellulose, and polyacrylonitrile (PAN) with aqueous ammonium sulfate solutions of different concentration as mobile phases. It was found that increasing the concentration of the salt in the mobile phase led to increased R-M values for all the substances. Linear relationships were established between salt concentration and R-M values and regression data of the plots obtained were used to determine the lipophilicity R-M(0) and C-0. Lipophilicity determined in this way was correlated with calculated log P values. For comparison of these results with chromatographic behavior in conventional RP TLC, the examined substances were subjected to thin-layer chromatography on RP-18 silica gel with methanol-water mobile phases. PB - Research Inst Medicinal Plants, Budakalasz T2 - Journal of Planar Chromatography: Modern TLC / Thin Layer Chromatography T1 - Examination of the hydrophobicity of ACE inhibitors and their active metabolites by salting-out thin-layer chromatography VL - 18 IS - 102 SP - 98 EP - 103 DO - 10.1556/JPC.18.2005.2.2 ER -
@article{ author = "Odovic, JV and Stojimirovic, BB and Aleksic, MB and Milojković-Opsenica, Dušanka and Tešić, Živoslav Lj.", year = "2005", abstract = "The behavior of five ACE inhibitors and their active degradation products in salting-out thin-layer chromatography (SO TLC) has been examined on silica gel, cellulose, and polyacrylonitrile (PAN) with aqueous ammonium sulfate solutions of different concentration as mobile phases. It was found that increasing the concentration of the salt in the mobile phase led to increased R-M values for all the substances. Linear relationships were established between salt concentration and R-M values and regression data of the plots obtained were used to determine the lipophilicity R-M(0) and C-0. Lipophilicity determined in this way was correlated with calculated log P values. For comparison of these results with chromatographic behavior in conventional RP TLC, the examined substances were subjected to thin-layer chromatography on RP-18 silica gel with methanol-water mobile phases.", publisher = "Research Inst Medicinal Plants, Budakalasz", journal = "Journal of Planar Chromatography: Modern TLC / Thin Layer Chromatography", title = "Examination of the hydrophobicity of ACE inhibitors and their active metabolites by salting-out thin-layer chromatography", volume = "18", number = "102", pages = "98-103", doi = "10.1556/JPC.18.2005.2.2" }
Odovic, J., Stojimirovic, B., Aleksic, M., Milojković-Opsenica, D.,& Tešić, Ž. Lj.. (2005). Examination of the hydrophobicity of ACE inhibitors and their active metabolites by salting-out thin-layer chromatography. in Journal of Planar Chromatography: Modern TLC / Thin Layer Chromatography Research Inst Medicinal Plants, Budakalasz., 18(102), 98-103. https://doi.org/10.1556/JPC.18.2005.2.2
Odovic J, Stojimirovic B, Aleksic M, Milojković-Opsenica D, Tešić ŽL. Examination of the hydrophobicity of ACE inhibitors and their active metabolites by salting-out thin-layer chromatography. in Journal of Planar Chromatography: Modern TLC / Thin Layer Chromatography. 2005;18(102):98-103. doi:10.1556/JPC.18.2005.2.2 .
Odovic, JV, Stojimirovic, BB, Aleksic, MB, Milojković-Opsenica, Dušanka, Tešić, Živoslav Lj., "Examination of the hydrophobicity of ACE inhibitors and their active metabolites by salting-out thin-layer chromatography" in Journal of Planar Chromatography: Modern TLC / Thin Layer Chromatography, 18, no. 102 (2005):98-103, https://doi.org/10.1556/JPC.18.2005.2.2 . .