Приказ основних података о документу

dc.creatorMijatovic, S
dc.creatorMaksimovic-Ivanic, D
dc.creatorRadovic, J
dc.creatorMiljković, Đorđe
dc.creatorKaludjerovic, GN
dc.creatorSabo, Tibor
dc.creatorTrajković, Vladimir S.
dc.date.accessioned2018-11-22T00:08:48Z
dc.date.available2018-11-22T00:08:48Z
dc.date.issued2005
dc.identifier.issn1420-682X
dc.identifier.urihttps://cherry.chem.bg.ac.rs/handle/123456789/733
dc.description.abstractThe present study describes the ability of an anthraquinone derivative aloe emodin (AE) to reduce the cytotoxic activity of the platinum(II)-based anticancer agent cisplatin toward murine L929 fibrosarcoma and C6 glioma cell lines. The protective effect of AE was demonstrated by MTT and crystal violet assays for cell viability, and involved supression of cisplatin-induced apoptosis and necrosis, as assessed by lactate dehydrogenase release and flow cytometric analysis of DNA fragmentation or phosphatidylserine exposure. Cell-based ELISA and Western blot analysis revealed that AE abolished cisplatin-triggered activation of extracellular signal-regulated kinase (ERK) in tumor cells, while activation of c-Jun N-terminal kinase was not significantly altered. A selective blockade of ERK activation with PD98059 mimicked the protective effect of AE treatment in both tumor cell lines. Moreover, AE failed to protect tumor cells against the ERK-independent toxicity of the Pt(IV)-based complex tetrachloro(O,O-dibutyl-ethylenediamine-N,N'-di-3-propanoate)platinum(IV). Taken together, these data indicate that herbal anthraquinone AE can downregulate the anticancer activity of cisplatin by blocking the activation of ERK in tumor cells.en
dc.publisherBirkhauser Verlag Ag, Basel
dc.rightsrestrictedAccess
dc.sourceCellular and Molecular Life Sciences / CMLS
dc.subjectaloe emodinen
dc.subjectcisplatinen
dc.subjectERKen
dc.subjectapoptosisen
dc.subjectnecrosisen
dc.subjectcanceren
dc.titleAloe emodin decreases the ERK-dependent anticancer activity of cisplatinen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМаксимовиц-Иваниц, Д; Сабо, Тибор; Калудјеровиц, ГН; Радовиц, Ј; Трајковиц, В; Мијатовиц, С; Миљковиц, Д;
dc.citation.volume62
dc.citation.issue11
dc.citation.spage1275
dc.citation.epage1282
dc.identifier.wos000232496800009
dc.identifier.doi10.1007/s00018-005-5041-3
dc.citation.other62(11): 1275-1282
dc.citation.rankM21
dc.identifier.pmid15905960
dc.type.versionpublishedVersionen
dc.identifier.scopus2-s2.0-21144443656


Документи

Thumbnail

Овај документ се појављује у следећим колекцијама

Приказ основних података о документу