Evaluation of the lipophilicity of some 1-arylpiperazines by planar chromatography
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The lipophilic character of some biologically active 1-arylpiperazines has been studied. A reversed-phase planar chromatographic procedure was established for determination of log Po-w values (n-octanol-water partition coefficients) for the compounds. The compounds were chromatographed with five so-called 'standards' on RP-18 silica plates with methanol-water and dioxane-water binary systems as mobile phases. n-Octanol-water partition coefficients for five standard compounds determined experimentally by use of the shake-flask method were used to obtain the log Po-w values of the 1-arylpiperazines investigated. Experimentally established log Po-w values were compared with log P values calculated by use of five different software packages.
Keywords:lipophilicity / RP-18 / 1-arylpiperazines
Source:Journal of Planar Chromatography: Modern TLC / Thin Layer Chromatography, 2005, 18, 105, 358-363
- Research Inst Medicinal Plants, Budakalasz