Allosteric regulation of the conformational dynamics of a cavitand receptor
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Inspired by allostery in nature, we synthesized cavitand 1 and investigated regulation of its conformational dynamics. Quantitative H-1 NMR studies have revealed that the rate of the conformational isomerization of 1 can be modulated using the external addition of acid. As 1 maintains its vase-like conformation in an acidic environment, ample opportunities for controlling the kinetics of molecular recognition, and thus reactivity, in this and related receptors have arisen.
Source:Organic Letters, 2006, 8, 17, 3697-3700
- Amer Chemical Soc, Washington