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dc.creatorTsoukatou, Maria
dc.creatorMarechal, Jean Philippe
dc.creatorHellio, Claire
dc.creatorNovaković, Irena T.
dc.creatorTufegdzie, Srdan
dc.creatorSladić, Dušan
dc.creatorGasic, Miroslav J.
dc.creatorClare, Anthony S.
dc.creatorVagias, Constantinos
dc.creatorRoussis, Vassilios
dc.date.accessioned2018-11-22T00:10:59Z
dc.date.available2018-11-22T00:10:59Z
dc.date.issued2007
dc.identifier.issn1420-3049
dc.identifier.urihttp://cherry.chem.bg.ac.rs/handle/123456789/840
dc.description.abstractThe sesquiterpene hydroquinone avarol (1) was isolated from the marine sponge Dysidea avara, whereas the corresponding quitione, avarone (2), was obtained by oxidation of avarol, and the significantly more lipophilic compounds [3 '-(P-chlorophenyl)avarone (3), 3 ',4 '-ethylenedithioavarone (4), 4 '-isopropylthioavarone (5), 4 '-tertbutylthioavarone (6), 4 '-propylthioavarone (7), 4 '-octylthioavarone (8)] were obtained by nucleophilic addition of thiols or p-chloroaniline to avarone. All these compounds were tested, at concentrations ranging from 0.5 to 50 mu g/mL, for their effect on the settlement of the cyprid stage of Balanus amphitrite, for toxicity to both nauplii and cyprids and for their growth inhibitory activity on marine bacteria (Cobetia marina, Marinobacterium stanieri, Vibrio fischeri and Pseudoalteromonas haloplanktis) and marine fungi (Halosphaeriopsis mediosetigera, Asteromyces cruciatus, Lulworthia uniseptata and Monodictys pelagica).en
dc.publisherMdpi Ag, Basel
dc.rightsopenAccess
dc.sourceMolecules
dc.subjectantifouling activityen
dc.subjectsettlement inhibitionen
dc.subjectantimicrobial activityen
dc.subjectavarolen
dc.subjectavaroneen
dc.titleEvaluation of the activity of the sponge metabolites avarol and avarone and their synthetic derivatives against fouling micro- and macroorganismsen
dc.typearticle
dc.rights.licenseBY
dcterms.abstractСладић, Душан; Цларе, Aнтхонy С.; Тсоукатоу, Мариа; Марецхал, Јеан Пхилиппе; Хеллио, Цлаире; Туфегдзие, Срдан; Гасиц, Мирослав Ј.; Вагиас, Цонстантинос; Роуссис, Вассилиос; Новаковиц, Ирена;
dc.citation.volume12
dc.citation.issue5
dc.citation.spage1022
dc.citation.epage1034
dc.identifier.wos000247200900009
dc.identifier.doi10.3390/12051022
dc.citation.other12(5): 1022-1034
dc.citation.rankM23
dc.identifier.pmid17873837
dc.type.versionpublishedVersion
dc.identifier.scopus2-s2.0-34249870148
dc.identifier.rcubKon_1793


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