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Evaluation of the activity of the sponge metabolites avarol and avarone and their synthetic derivatives against fouling micro- and macroorganisms
dc.creator | Tsoukatou, Maria | |
dc.creator | Marechal, Jean Philippe | |
dc.creator | Hellio, Claire | |
dc.creator | Novaković, Irena T. | |
dc.creator | Tufegdzie, Srdan | |
dc.creator | Sladić, Dušan | |
dc.creator | Gasic, Miroslav J. | |
dc.creator | Clare, Anthony S. | |
dc.creator | Vagias, Constantinos | |
dc.creator | Roussis, Vassilios | |
dc.date.accessioned | 2018-11-22T00:10:59Z | |
dc.date.available | 2018-11-22T00:10:59Z | |
dc.date.issued | 2007 | |
dc.identifier.issn | 1420-3049 | |
dc.identifier.uri | https://cherry.chem.bg.ac.rs/handle/123456789/840 | |
dc.description.abstract | The sesquiterpene hydroquinone avarol (1) was isolated from the marine sponge Dysidea avara, whereas the corresponding quitione, avarone (2), was obtained by oxidation of avarol, and the significantly more lipophilic compounds [3 '-(P-chlorophenyl)avarone (3), 3 ',4 '-ethylenedithioavarone (4), 4 '-isopropylthioavarone (5), 4 '-tertbutylthioavarone (6), 4 '-propylthioavarone (7), 4 '-octylthioavarone (8)] were obtained by nucleophilic addition of thiols or p-chloroaniline to avarone. All these compounds were tested, at concentrations ranging from 0.5 to 50 mu g/mL, for their effect on the settlement of the cyprid stage of Balanus amphitrite, for toxicity to both nauplii and cyprids and for their growth inhibitory activity on marine bacteria (Cobetia marina, Marinobacterium stanieri, Vibrio fischeri and Pseudoalteromonas haloplanktis) and marine fungi (Halosphaeriopsis mediosetigera, Asteromyces cruciatus, Lulworthia uniseptata and Monodictys pelagica). | en |
dc.publisher | Mdpi Ag, Basel | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Molecules | |
dc.subject | antifouling activity | en |
dc.subject | settlement inhibition | en |
dc.subject | antimicrobial activity | en |
dc.subject | avarol | en |
dc.subject | avarone | en |
dc.title | Evaluation of the activity of the sponge metabolites avarol and avarone and their synthetic derivatives against fouling micro- and macroorganisms | en |
dc.type | article | |
dc.rights.license | BY | |
dcterms.abstract | Сладић, Душан; Цларе, Aнтхонy С.; Тсоукатоу, Мариа; Марецхал, Јеан Пхилиппе; Хеллио, Цлаире; Туфегдзие, Срдан; Гасиц, Мирослав Ј.; Вагиас, Цонстантинос; Роуссис, Вассилиос; Новаковиц, Ирена; | |
dc.citation.volume | 12 | |
dc.citation.issue | 5 | |
dc.citation.spage | 1022 | |
dc.citation.epage | 1034 | |
dc.identifier.wos | 000247200900009 | |
dc.identifier.doi | 10.3390/12051022 | |
dc.citation.other | 12(5): 1022-1034 | |
dc.citation.rank | M23 | |
dc.identifier.pmid | 17873837 | |
dc.type.version | publishedVersion | |
dc.identifier.scopus | 2-s2.0-34249870148 | |
dc.identifier.fulltext | https://cherry.chem.bg.ac.rs/bitstream/id/10037/838.pdf |