Приказ основних података о документу

dc.creatorGrgurić-Šipka, Sanja
dc.creatorKowol, Christian R.
dc.creatorValiahdi, Seied-Mojtaba
dc.creatorEichinger, Rene
dc.creatorJakupec, Michael A.
dc.creatorRoller, Alexander
dc.creatorShova, Sergiu
dc.creatorArion, Vladimir B.
dc.creatorKeppler, Bernhard K.
dc.date.accessioned2018-11-22T00:11:07Z
dc.date.available2018-11-22T00:11:07Z
dc.date.issued2007
dc.identifier.issn1434-1948
dc.identifier.urihttp://cherry.chem.bg.ac.rs/handle/123456789/849
dc.description.abstractTwo ruthenium(II) complexes of 2-acetylpyridine N ',N '-dimethylthiosemicarbazone (HL1) and phenanthrenequinone thiosemicarbazone (HL2), namely [(RuCI)-C-II(L-1)(PPh3)(2)] (1) and [(RuCl)-Cl-II(L-2) (PPh3)(2)] (2), have been synthesised and characterised by IR, UV/Vis and NMR spectroscopy, electrospray mass spectrometry, cyclic voltammetry and X-ray crystallography. In addition, the X-ray crystal structure of [(RuCl2)-Cl-III(L-2)- PPh3]center dot dmso center dot 1.25H(2)O (3 center dot dmso center dot 1.25H(2)O) is reported. The reaction of [(RuCl2)-Cl-II(dmsO)(4)] with HL1 and 1,3,5-triaza-7-phosphaadamantane (PTA) gives the highly water-soluble complex [(RuCl)-Cl-II(L-1)(HPTA)(2)]Cl-2 center dot C2H5OH center dot H2O (4 center dot C2H5OH center dot H2O) (S-25 degrees C - gt = 250 mg/mL), which has been fully characterised. Complex 4 shows strong antiproliferative effects in low micromolar concentrations in the ovarian carcinoma cell line 41M (IC50 = 0.87 mu m) and more moderate activity in the breast cancer cell line SK-BR-3 (IC50 = 39 mu m). The activity of the compound is 6.5- and 5.4-times higher at pH = 6.0 than at pH = 7.4 in the non-small cell lung cancer cell line A549 and the colon carcinoma cell line HT-29 (GI(50) = 24 and 8.0 mu m at pH = 6.0 for A549 and HT-29, respectively). ((c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007).en
dc.publisherWiley-V C H Verlag Gmbh, Weinheim
dc.rightsrestrictedAccess
dc.sourceEuropean Journal of Inorganic Chemistry
dc.subjectantitumour agentsen
dc.subjectrutheniumen
dc.subjectN,S ligandsen
dc.subjectX-ray diffractionen
dc.titleRuthenium(II) complexes of thiosemicarbazones: The first Walter-soluble complex with pH-Dependent antiproliferative activityen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractAрион, Владимир Б.; Кепплер, Бернхард К.; Коwол, Цхристиан Р.; Роллер, Aлеxандер; Еицхингер, Рене; Валиахди, Сеиед-Мојтаба; Схова, Сергиу; Јакупец, Мицхаел A.; Гргурић-Шипка, Сања;
dc.citation.issue18
dc.citation.spage2870
dc.citation.epage2878
dc.identifier.wos000247937300039
dc.identifier.doi10.1002/ejic.200601196
dc.citation.other(18): 2870-2878
dc.citation.rankM21
dc.type.versionpublishedVersionen
dc.identifier.scopus2-s2.0-34447515399
dc.identifier.rcubKon_1802


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