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dc.creatorStanković, Miroslava
dc.creatorTešević, Vele
dc.creatorVajs, Vlatka
dc.creatorTodorović, Nina
dc.creatorMilosavljević, Slobodan M.
dc.creatorGođevac, Dejan
dc.date.accessioned2018-11-22T00:13:17Z
dc.date.available2018-11-22T00:13:17Z
dc.date.issued2008
dc.identifier.issn0032-0943
dc.identifier.urihttp://cherry.chem.bg.ac.rs/handle/123456789/952
dc.description.abstractThe distribution of polyphenolic compounds in a grape (Vitis vinifera) seed extract (GSE) was determined using LC/ESI-TOF MS, HPLC/DAD, and (13)C-NMR. The 17 identified compounds comprised gallic and protocatechuic acid, catetchin and epicatechin monomers, procyanidin oligomers, and procyanidin gallates. This study addresses the in vitro effects of grape seed extract (GSE) on the frequency of micronuclei with reference to the antioxidant status in human lymphocytes. To establish the most effective protective support, we used four different concentrations of GSE, in the range 1-6 mu g/mL. Treatment of lymphocytes with GSE at a concentration of 2.5 mu g/mL induced a significant decrease in the frequency of micronuclei by 40%, reduction of malonyldialdehyde production by 30%, while a concentration of 5 mu g/mL increased catalase and glutathione S-transferase activity by 10 % and 15 %, respectively. These results demonstrate that GSE may be effective in the prevention of oxidative lymphocyte damage by ROS.en
dc.publisherGeorg Thieme Verlag Kg, Stuttgart
dc.rightsrestrictedAccess
dc.sourcePlanta Medica
dc.subjectVitis viniferaen
dc.subjectVitaceaeen
dc.subjectmicronucleus testen
dc.subjectantioxidant enzymesen
dc.subjecthuman lymphocytesen
dc.subjectLC/MSen
dc.subjectNMRen
dc.titleAntioxidant properties of grape seed extract on human lymphocyte oxidative defenceen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractВајс, Влатка; Милосављевицз, Слободан; Годевац, Дејан; Станковиц, Мирослава; Тешевић, Веле; Тодоровиц, Нина;
dc.citation.volume74
dc.citation.issue7
dc.citation.spage730
dc.citation.epage735
dc.identifier.wos000257284700005
dc.identifier.doi10.1055/s-2008-1074521
dc.citation.other74(7): 730-735
dc.citation.rankM21
dc.identifier.pmid18496781
dc.identifier.scopus2-s2.0-45849128011
dc.identifier.rcubKon_1905


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