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dc.creatorOpsenica, Dejan M.
dc.creatorTerzic, Natasa
dc.creatorSmith, Philip L.
dc.creatorYang, Youngsun
dc.creatorAnova, Lalaine
dc.creatorSmith, Kirsten S.
dc.creatorŠolaja, Bogdan A.
dc.date.accessioned2018-11-22T00:13:22Z
dc.date.available2018-11-22T00:13:22Z
dc.date.issued2008
dc.identifier.issn0968-0896
dc.identifier.urihttp://cherry.chem.bg.ac.rs/handle/123456789/957
dc.description.abstractEleven new tetraoxanes possessing cholic acid-derived carrier and isopropylidene moiety were synthesized and were tested in vitro and in vivo. In vitro screening revealed that nine of them were more potent against CQ-resistant W2 than CQ-susceptible D6 strain and that two of them were equally or more potent than artemisinin and mefloquine against multi- drug resistant TM91C235 strain. Amine 8 cured all mice at the dose of 160 mg/kg/day, while the anilide 9 exhibited MCD lt = 20 mg/kg/day. The diol 13 was most potent antiproliferative with GI(50), TGI, LC50 MG_MID 0.98 mu M, 3.80 mu M, 11.22 mu M, respectively. All tested compounds showed no toxic effects. (c) 2008 Elsevier Ltd. All rights reserved.en
dc.publisherPergamon-Elsevier Science Ltd, Oxford
dc.rightsrestrictedAccess
dc.sourceBioorganic and Medicinal Chemistry
dc.subjectmixed steroidal tetraoxanesen
dc.subjectcholic aciden
dc.subjectantimalarialsen
dc.subjectantiproliferativesen
dc.subjectmetabolic stabilityen
dc.titleMixed tetraoxanes containing the acetone subunit as antimalarialsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractОпсеница, Дејан М.; Aнова, Лалаине; Смитх, Кирстен С.; Смитх, Пхилип Л.; Терзиц, Натаса; Yанг, Yоунгсун; Шолаја, Богдан A.;
dc.citation.volume16
dc.citation.issue14
dc.citation.spage7039
dc.citation.epage7045
dc.identifier.wos000257829600042
dc.identifier.doi10.1016/j.bmc.2008.05.017
dc.citation.other16(14): 7039-7045
dc.citation.rankM21
dc.identifier.pmid18550377
dc.identifier.rcubKon_1910


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