Приказ основних података о документу

dc.creatorGomez-Ruiz, Santiago
dc.creatorKaluđerović, Goran N.
dc.creatorPrashar, Sanjiv
dc.creatorPolo-Ceron, Dorian
dc.creatorFajardo, Mariano
dc.creatorŽižak, Željko S.
dc.creatorSabo, Tibor
dc.creatorJuranić, Zorica D.
dc.date.accessioned2018-11-22T00:13:24Z
dc.date.available2018-11-22T00:13:24Z
dc.date.issued2008
dc.identifier.issn0162-0134
dc.identifier.urihttps://cherry.chem.bg.ac.rs/handle/123456789/959
dc.description.abstractA variety of substituted titanocene and ansa-titanocene complexes have been synthesized and characterized using traditional methods. The cytotoxic activity of the different titanocene complexes was tested against tumour cell lines human adenocarcinoma HeLa, human myelogenous leukemia K562, human malignant melanoma Fem-x and normal immunocompetent cells, peripheral blood mononuclear cells PBMC. Alkenyl substitution, either on the cyclopentadienyl ring or on the silicon-atom ansa-bridge of the titanocene compounds [Ti{Me2Si(eta(5)-C5Me4) (eta(5)-C5H3{CMe2CH2CH2CH=CH2})}Cl-2] (8), [Ti{Me(CH2=CH)Si(eta(5)-C5Me4)(eta(5)-C5H4)}Cl-2] (9) and [Ti(eta(5)- C5H4{CMe2CH2CH2CH=CH2})(2)Cl-2] (12) showed higher cytotoxic activities (IC50 values from 24 +/- 3 to 151 +/- 10 mu M) relative to complexes bearing an additional alkenyl-substituted silyl substituent on the silicon bridge [Ti{Me{(CH2=CH)Me2SiCH2CH2}Si(eta(5)-C5Me4)(eta(5)-C5H4)}Cl-2] (10) and [Ti{Me{(CH2=CH)(3)SiCH2CH2} Si(eta(5)-C5Me4)(eta(5) -C5H4)}Cl-2] (11) which causes a dramatic decrease of the cytotoxicity (IC50 values from 155 +/- 9 to gt 200 mu M). In addition, the synthesis of the analogous niobocene complex [Nb(eta(5)- C5H4{CMe2CH2CH2CH=CH2})(2)Cl-2] (13), is described. Structural studies based on DFT calculations of the most active complexes 8, 9 and 12 and the X-ray crystal structure of 13 are reported. (c) 2008 Elsevier Inc. All rights reserved.en
dc.publisherElsevier Science Inc, New York
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/142010/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/145006/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Inorganic Biochemistry
dc.subjectanticancer drugsen
dc.subjecttitanoceneen
dc.subjectadenocarcinoma HeLaen
dc.subjecthuman myelogenous leukemia K562en
dc.subjecthuman malignant melanoma Fem-xen
dc.titleCytotoxic studies of substituted titanocene and ansa-titanocene anticancer drugsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЗизак, Зељко; Јураниц, Зорица Д.; Поло-Церон, Дориан; Сабо, Тибор; Гомез-Руиз, Сантиаго; Калудеровиц, Горан Н.; Прасхар, Сањив; Фајардо, Мариано;
dc.citation.volume102
dc.citation.issue8
dc.citation.spage1558
dc.citation.epage1570
dc.identifier.wos000258012000002
dc.identifier.doi10.1016/j.jinorgbio.2008.02.001
dc.citation.other102(8): 1558-1570
dc.citation.rankM21
dc.identifier.pmid18353439
dc.type.versionpublishedVersionen
dc.identifier.scopus2-s2.0-47049100123


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