An approximate linear solvation energy relationships model based on Snyder's selectivity parameters. Chromatographic behavior of some 1-aralkyl-4-arylpiperazines
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In order to elucidate the influence of the mobile phase composition on the retention of some 1-aralkyl-4-arylpiperazines, Snyder's selectivity and polarity concept for building a simple linear solvation energy relationships model of chromatographic behavior was used. Maximum variability of mobile phase selectivity was achieved by using ternary mixtures of solvents from three different corners of the Snyder selectivity triangle: methanol as a strong proton donor, acetone as a strong proton acceptor and dimethyl formamide as a dipole interactor. Water was added to keep elution strength constant. Mobile phase composition was varied using Simplex-lattice mixture design. Selectivity parameters were calculated on the basis of linear relationships between volume fractions of pure solvents and their chi (e) , chi (d) , chi (n) values. For seven-substituted 1-aralkyl-4-arylpiperazines R (M) values were measured and correlated with previously calculated selectivity parameters. Mathematical model...s obtained are discussed according to the structural properties of the studied compounds.
Keywords:thin-layer chromatography / arylpiperazines / linear solvation energy relationships / Snyder's selectivity parameter / polarity index
Source:Chromatographia, 2008, 68, 5-6, 453-458
- Springer Heidelberg, Heidelberg