Synthesis, characterization and antitumor activity of Cu(II), Co(II), Zn(II) and Mn(II) complex compounds with aminothiazole acetate derivative
2010
Аутори
Alexandru, Maria-GabrielaĆirković-Veličković, Tanja
Jitaru, Ioana
Grgurić-Šipka, Sanja
Draghici, Constantin
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
This paper presents the synthesis of complex compounds of type [M(L1)(2)], where M(II) = Cu (1), Co (2), Zn (3), L1 = 2-aminothiazole-4-acetate and [Mn(L1)(2)(H2O)] (4) using ethyl 2-(2-aminothiazole-4-yl) acetate (L), and characterization by elemental analysis, magnetic susceptibilities, IR, 1H-NMR, UV-Vis spectroscopy and for [Mn(L1)(2)(H2O)] also by X-ray diffraction. In vitro cytotoxicity studies were performed on human cervix adenocarcinoma, HeLa cells. The antitumor selectivity was assessed using normal human peripheral blood mononuclear cells, PBMC as control.
Кључне речи:
Aminothiazole / Cytotoxicity / HeLa / PBMCИзвор:
Central European Journal of Chemistry, 2010, 8, 3, 639-645Издавач:
- De Gruyter Poland Sp Zoo, Warsaw
Финансирање / пројекти:
- Испитивање структуре и функције биолошки важних макромолекула у физиолошким и патолошким стањима (RS-MESTD-MPN2006-2010-142020)
DOI: 10.2478/s11532-010-0022-2
ISSN: 1895-1066
WoS: 000277021300022
Scopus: 2-s2.0-77951908042
Колекције
Институција/група
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Alexandru, Maria-Gabriela AU - Ćirković-Veličković, Tanja AU - Jitaru, Ioana AU - Grgurić-Šipka, Sanja AU - Draghici, Constantin PY - 2010 UR - https://cherry.chem.bg.ac.rs/handle/123456789/1075 AB - This paper presents the synthesis of complex compounds of type [M(L1)(2)], where M(II) = Cu (1), Co (2), Zn (3), L1 = 2-aminothiazole-4-acetate and [Mn(L1)(2)(H2O)] (4) using ethyl 2-(2-aminothiazole-4-yl) acetate (L), and characterization by elemental analysis, magnetic susceptibilities, IR, 1H-NMR, UV-Vis spectroscopy and for [Mn(L1)(2)(H2O)] also by X-ray diffraction. In vitro cytotoxicity studies were performed on human cervix adenocarcinoma, HeLa cells. The antitumor selectivity was assessed using normal human peripheral blood mononuclear cells, PBMC as control. PB - De Gruyter Poland Sp Zoo, Warsaw T2 - Central European Journal of Chemistry T1 - Synthesis, characterization and antitumor activity of Cu(II), Co(II), Zn(II) and Mn(II) complex compounds with aminothiazole acetate derivative VL - 8 IS - 3 SP - 639 EP - 645 DO - 10.2478/s11532-010-0022-2 ER -
@article{ author = "Alexandru, Maria-Gabriela and Ćirković-Veličković, Tanja and Jitaru, Ioana and Grgurić-Šipka, Sanja and Draghici, Constantin", year = "2010", abstract = "This paper presents the synthesis of complex compounds of type [M(L1)(2)], where M(II) = Cu (1), Co (2), Zn (3), L1 = 2-aminothiazole-4-acetate and [Mn(L1)(2)(H2O)] (4) using ethyl 2-(2-aminothiazole-4-yl) acetate (L), and characterization by elemental analysis, magnetic susceptibilities, IR, 1H-NMR, UV-Vis spectroscopy and for [Mn(L1)(2)(H2O)] also by X-ray diffraction. In vitro cytotoxicity studies were performed on human cervix adenocarcinoma, HeLa cells. The antitumor selectivity was assessed using normal human peripheral blood mononuclear cells, PBMC as control.", publisher = "De Gruyter Poland Sp Zoo, Warsaw", journal = "Central European Journal of Chemistry", title = "Synthesis, characterization and antitumor activity of Cu(II), Co(II), Zn(II) and Mn(II) complex compounds with aminothiazole acetate derivative", volume = "8", number = "3", pages = "639-645", doi = "10.2478/s11532-010-0022-2" }
Alexandru, M., Ćirković-Veličković, T., Jitaru, I., Grgurić-Šipka, S.,& Draghici, C.. (2010). Synthesis, characterization and antitumor activity of Cu(II), Co(II), Zn(II) and Mn(II) complex compounds with aminothiazole acetate derivative. in Central European Journal of Chemistry De Gruyter Poland Sp Zoo, Warsaw., 8(3), 639-645. https://doi.org/10.2478/s11532-010-0022-2
Alexandru M, Ćirković-Veličković T, Jitaru I, Grgurić-Šipka S, Draghici C. Synthesis, characterization and antitumor activity of Cu(II), Co(II), Zn(II) and Mn(II) complex compounds with aminothiazole acetate derivative. in Central European Journal of Chemistry. 2010;8(3):639-645. doi:10.2478/s11532-010-0022-2 .
Alexandru, Maria-Gabriela, Ćirković-Veličković, Tanja, Jitaru, Ioana, Grgurić-Šipka, Sanja, Draghici, Constantin, "Synthesis, characterization and antitumor activity of Cu(II), Co(II), Zn(II) and Mn(II) complex compounds with aminothiazole acetate derivative" in Central European Journal of Chemistry, 8, no. 3 (2010):639-645, https://doi.org/10.2478/s11532-010-0022-2 . .