Involvement of the ADAM 12 in Thrombin-Induced Rat's VSMCs Proliferation
Apstrakt
Cardiovascular disease is the largest single cause of mortality and its major underlying pathology is atherosclerosis. The proliferation of vascular smooth muscle cells (VSMCs) is a key event in the pathogenesis of the various vascular diseases, including atherosclerosis and hypertension. Thrombin (Thr) is involved in the abnormal proliferation of VSMCs associated with atherosclerosis and hypertension. ADAMs (A Disintegrin And Metalloproteinase) are transmembrane metalloproteinases, belonging to the adamalysins group, that are distinct from matrix metalloproteinases (MMPs) in a way as they have an extracellular disintegrin domain and cytoplasmic domain that can associate with intracellular proteins. There is limited knowledge about the presence of ADAM metalloproteinase activity in Thr-induced VSMCs proliferation. Therefore, this review examines recent findings in signaling mechanisms employed by Thr in modulating the regulation of proliferation of VSMCs with particular emphasis on inv...olvement of ADAM 12 which has been identified as an important mediator of VSMCs hypertrophy and vascular diseases. These findings are critical for understanding the role of Thr in vascular biology and vascular diseases.
Ključne reči:
ADAM 12 / Atherosclerosis / Thrombin / Proliferation / VSMC / MMP / Cardiovascular diseases / Hypertension / Hypertrophy / Vascular diseasesIzvor:
Current Medicinal Chemistry, 2011, 18, 22, 3382-3386Izdavač:
- Bentham Science Publ Ltd, Sharjah
Finansiranje / projekti:
- Hormonska regulacija ekspresije i aktivnosti azot oksid sintaze i natrijum-kalijumove pumpe u eksperimentalnim modelima insulinske rezistencije, dijabetesa i kardiovaskularnih poremećaja (RS-MESTD-Basic Research (BR or ON)-173033)
- Republic of France, Ministry of Foreign Affairs
- CNRS
- Pavle Savic [337-00-359/2005-01/16]
- University Pierre and Marie Curie
DOI: 10.2174/092986711796504709
ISSN: 0929-8673
PubMed: 21728962
WoS: 000294405600013
Scopus: 2-s2.0-79961088085
Kolekcije
Institucija/grupa
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Smiljanić, Katarina AU - Dobutovic, B. AU - Obradović, Milan AU - Nikolić, D. AU - Marche, P. AU - Isenovic, E. R. PY - 2011 UR - https://cherry.chem.bg.ac.rs/handle/123456789/1195 AB - Cardiovascular disease is the largest single cause of mortality and its major underlying pathology is atherosclerosis. The proliferation of vascular smooth muscle cells (VSMCs) is a key event in the pathogenesis of the various vascular diseases, including atherosclerosis and hypertension. Thrombin (Thr) is involved in the abnormal proliferation of VSMCs associated with atherosclerosis and hypertension. ADAMs (A Disintegrin And Metalloproteinase) are transmembrane metalloproteinases, belonging to the adamalysins group, that are distinct from matrix metalloproteinases (MMPs) in a way as they have an extracellular disintegrin domain and cytoplasmic domain that can associate with intracellular proteins. There is limited knowledge about the presence of ADAM metalloproteinase activity in Thr-induced VSMCs proliferation. Therefore, this review examines recent findings in signaling mechanisms employed by Thr in modulating the regulation of proliferation of VSMCs with particular emphasis on involvement of ADAM 12 which has been identified as an important mediator of VSMCs hypertrophy and vascular diseases. These findings are critical for understanding the role of Thr in vascular biology and vascular diseases. PB - Bentham Science Publ Ltd, Sharjah T2 - Current Medicinal Chemistry T1 - Involvement of the ADAM 12 in Thrombin-Induced Rat's VSMCs Proliferation VL - 18 IS - 22 SP - 3382 EP - 3386 DO - 10.2174/092986711796504709 ER -
@article{ author = "Smiljanić, Katarina and Dobutovic, B. and Obradović, Milan and Nikolić, D. and Marche, P. and Isenovic, E. R.", year = "2011", abstract = "Cardiovascular disease is the largest single cause of mortality and its major underlying pathology is atherosclerosis. The proliferation of vascular smooth muscle cells (VSMCs) is a key event in the pathogenesis of the various vascular diseases, including atherosclerosis and hypertension. Thrombin (Thr) is involved in the abnormal proliferation of VSMCs associated with atherosclerosis and hypertension. ADAMs (A Disintegrin And Metalloproteinase) are transmembrane metalloproteinases, belonging to the adamalysins group, that are distinct from matrix metalloproteinases (MMPs) in a way as they have an extracellular disintegrin domain and cytoplasmic domain that can associate with intracellular proteins. There is limited knowledge about the presence of ADAM metalloproteinase activity in Thr-induced VSMCs proliferation. Therefore, this review examines recent findings in signaling mechanisms employed by Thr in modulating the regulation of proliferation of VSMCs with particular emphasis on involvement of ADAM 12 which has been identified as an important mediator of VSMCs hypertrophy and vascular diseases. These findings are critical for understanding the role of Thr in vascular biology and vascular diseases.", publisher = "Bentham Science Publ Ltd, Sharjah", journal = "Current Medicinal Chemistry", title = "Involvement of the ADAM 12 in Thrombin-Induced Rat's VSMCs Proliferation", volume = "18", number = "22", pages = "3382-3386", doi = "10.2174/092986711796504709" }
Smiljanić, K., Dobutovic, B., Obradović, M., Nikolić, D., Marche, P.,& Isenovic, E. R.. (2011). Involvement of the ADAM 12 in Thrombin-Induced Rat's VSMCs Proliferation. in Current Medicinal Chemistry Bentham Science Publ Ltd, Sharjah., 18(22), 3382-3386. https://doi.org/10.2174/092986711796504709
Smiljanić K, Dobutovic B, Obradović M, Nikolić D, Marche P, Isenovic ER. Involvement of the ADAM 12 in Thrombin-Induced Rat's VSMCs Proliferation. in Current Medicinal Chemistry. 2011;18(22):3382-3386. doi:10.2174/092986711796504709 .
Smiljanić, Katarina, Dobutovic, B., Obradović, Milan, Nikolić, D., Marche, P., Isenovic, E. R., "Involvement of the ADAM 12 in Thrombin-Induced Rat's VSMCs Proliferation" in Current Medicinal Chemistry, 18, no. 22 (2011):3382-3386, https://doi.org/10.2174/092986711796504709 . .