Thrombin and vascular inflammation
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2012
Authors
Popović, MilanSmiljanić, Katarina
Dobutović, Branislava
Syrovets, Tatiana
Simmet, Thomas
Isenovic, Esma R.
Article (Published version)
Metadata
Show full item recordAbstract
Vascular endothelium is a key regulator of homeostasis. In physiological conditions it mediates vascular dilatation, prevents platelet adhesion, and inhibits thrombin generation. However, endothelial dysfunction caused by physical injury of the vascular wall, for example during balloon angioplasty, acute or chronic inflammation, such as in atherothrombosis, creates a proinflammatory environment which supports leukocyte transmigration toward inflammatory sites. At the same time, the dysfunction promotes thrombin generation, fibrin deposition, and coagulation. The serine protease thrombin plays a pivotal role in the coagulation cascade. However, thrombin is not only the key effector of coagulation cascade; it also plays a significant role in inflammatory diseases. It shows an array of effects on endothelial cells, vascular smooth muscle cells, monocytes, and platelets, all of which participate in the vascular pathophysiology such as atherothrombosis. Therefore, thrombin can be considered... as an important modulatory molecule of vascular homeostasis. This review summarizes the existing evidence on the role of thrombin in vascular inflammation.
Keywords:
Thrombin / Endothelium / Vascular inflammation / AtherosclerosisSource:
Molecular and Cellular Biochemistry, 2012, 359, 1-2, 301-313Publisher:
- Springer, Dordrecht
Funding / projects:
- Hormonal regulation of expression and activity of the nitric oxide synthase and sodium-potassium pump in experimental models of insulin resistance, diabetes and cardiovascular disorders (RS-MESTD-Basic Research (BR or ON)-173033)
- Genetic basis of human vascular and inflammatory diseases (RS-MESTD-Basic Research (BR or ON)-175085)
- Deutsche Forschungsgemeinschaft [Si 285/7-1]
DOI: 10.1007/s11010-011-1024-x
ISSN: 0300-8177
PubMed: 21858738
WoS: 000297174700031
Scopus: 2-s2.0-83555164932
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Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Popović, Milan AU - Smiljanić, Katarina AU - Dobutović, Branislava AU - Syrovets, Tatiana AU - Simmet, Thomas AU - Isenovic, Esma R. PY - 2012 UR - https://cherry.chem.bg.ac.rs/handle/123456789/1220 AB - Vascular endothelium is a key regulator of homeostasis. In physiological conditions it mediates vascular dilatation, prevents platelet adhesion, and inhibits thrombin generation. However, endothelial dysfunction caused by physical injury of the vascular wall, for example during balloon angioplasty, acute or chronic inflammation, such as in atherothrombosis, creates a proinflammatory environment which supports leukocyte transmigration toward inflammatory sites. At the same time, the dysfunction promotes thrombin generation, fibrin deposition, and coagulation. The serine protease thrombin plays a pivotal role in the coagulation cascade. However, thrombin is not only the key effector of coagulation cascade; it also plays a significant role in inflammatory diseases. It shows an array of effects on endothelial cells, vascular smooth muscle cells, monocytes, and platelets, all of which participate in the vascular pathophysiology such as atherothrombosis. Therefore, thrombin can be considered as an important modulatory molecule of vascular homeostasis. This review summarizes the existing evidence on the role of thrombin in vascular inflammation. PB - Springer, Dordrecht T2 - Molecular and Cellular Biochemistry T1 - Thrombin and vascular inflammation VL - 359 IS - 1-2 SP - 301 EP - 313 DO - 10.1007/s11010-011-1024-x ER -
@article{ author = "Popović, Milan and Smiljanić, Katarina and Dobutović, Branislava and Syrovets, Tatiana and Simmet, Thomas and Isenovic, Esma R.", year = "2012", abstract = "Vascular endothelium is a key regulator of homeostasis. In physiological conditions it mediates vascular dilatation, prevents platelet adhesion, and inhibits thrombin generation. However, endothelial dysfunction caused by physical injury of the vascular wall, for example during balloon angioplasty, acute or chronic inflammation, such as in atherothrombosis, creates a proinflammatory environment which supports leukocyte transmigration toward inflammatory sites. At the same time, the dysfunction promotes thrombin generation, fibrin deposition, and coagulation. The serine protease thrombin plays a pivotal role in the coagulation cascade. However, thrombin is not only the key effector of coagulation cascade; it also plays a significant role in inflammatory diseases. It shows an array of effects on endothelial cells, vascular smooth muscle cells, monocytes, and platelets, all of which participate in the vascular pathophysiology such as atherothrombosis. Therefore, thrombin can be considered as an important modulatory molecule of vascular homeostasis. This review summarizes the existing evidence on the role of thrombin in vascular inflammation.", publisher = "Springer, Dordrecht", journal = "Molecular and Cellular Biochemistry", title = "Thrombin and vascular inflammation", volume = "359", number = "1-2", pages = "301-313", doi = "10.1007/s11010-011-1024-x" }
Popović, M., Smiljanić, K., Dobutović, B., Syrovets, T., Simmet, T.,& Isenovic, E. R.. (2012). Thrombin and vascular inflammation. in Molecular and Cellular Biochemistry Springer, Dordrecht., 359(1-2), 301-313. https://doi.org/10.1007/s11010-011-1024-x
Popović M, Smiljanić K, Dobutović B, Syrovets T, Simmet T, Isenovic ER. Thrombin and vascular inflammation. in Molecular and Cellular Biochemistry. 2012;359(1-2):301-313. doi:10.1007/s11010-011-1024-x .
Popović, Milan, Smiljanić, Katarina, Dobutović, Branislava, Syrovets, Tatiana, Simmet, Thomas, Isenovic, Esma R., "Thrombin and vascular inflammation" in Molecular and Cellular Biochemistry, 359, no. 1-2 (2012):301-313, https://doi.org/10.1007/s11010-011-1024-x . .