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Novel octahedral Pt(IV) complex with di-n-propyl-(S,S)-ethylenediamine-N,N '-di-2-(3-cyclohexyl)propanoato ligand exerts potent immunomodulatory effects
dc.creator | Miljković, Đorđe | |
dc.creator | Poljarević, Jelena | |
dc.creator | Petkovic, Filip | |
dc.creator | Blazevski, Jana | |
dc.creator | Momčilović, Miljana | |
dc.creator | Nikolic, Ivana | |
dc.creator | Saksida, Tamara | |
dc.creator | Stošić-Grujičić, Stanislava D. | |
dc.creator | Grgurić-Šipka, Sanja | |
dc.creator | Sabo, Tibor | |
dc.date.accessioned | 2018-11-22T00:20:38Z | |
dc.date.available | 2018-11-22T00:20:38Z | |
dc.date.issued | 2012 | |
dc.identifier.issn | 0223-5234 | |
dc.identifier.uri | https://cherry.chem.bg.ac.rs/handle/123456789/1258 | |
dc.description.abstract | We have recently reported that a novel octahedral Pt(IV) complex with di-n-propyl-(S,S)-ethylenediamine-N,N'-di-2-(3-cyclohexyl)propanoato ligand has a potent cytotoxic effect on glioma, melanoma and fibrosarcoma cell lines. In this work, we investigated the influence of the Pt(IV) compound on immune cells. We determined its effect on the viability of spleen cells and lymph node cells and on their capability to produce interferon (IFN)-gamma and interleukin (IL)-17. Also, we researched the compound's impact on peritoneal macrophages and generation of NO in these cells. Our results show that the complex has limited influence on cell viability of immune cells, but profound inhibitory effect on the production of examined immune mediators. These results are valuable as they show that the novel Pt(IV) complex applied in concentrations which are effective against tumor cells do not affect immune cell viability. Moreover, they also imply that the complex has immunomodulatory properties. (C) 2011 Elsevier Masson SAS. All rights reserved. | en |
dc.publisher | Elsevier France-Editions Scientifiques Medicales Elsevier, Paris | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172035/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173013/RS// | |
dc.rights | restrictedAccess | |
dc.source | European Journal of Medicinal Chemistry | |
dc.subject | Bioinorganic chemistry | en |
dc.subject | Platinum | en |
dc.subject | Cytotoxicity | en |
dc.subject | Immunology | en |
dc.subject | Cytokines | en |
dc.title | Novel octahedral Pt(IV) complex with di-n-propyl-(S,S)-ethylenediamine-N,N '-di-2-(3-cyclohexyl)propanoato ligand exerts potent immunomodulatory effects | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Момциловиц, Миљана; Блазевски, Јана; Пољаревић, Јелена; Саксида, Тамара; Николиц, Ивана; Миљковиц, Дјордје; Сабо, Тибор; Гргурић-Шипка, Сања; Петковиц, Филип; Стосиц-Грујициц, Станислава; | |
dc.citation.volume | 47 | |
dc.citation.spage | 194 | |
dc.citation.epage | 201 | |
dc.identifier.wos | 000301169800021 | |
dc.identifier.doi | 10.1016/j.ejmech.2011.10.042 | |
dc.citation.other | 47: 194-201 | |
dc.citation.rank | M21 | |
dc.identifier.pmid | 22071257 | |
dc.type.version | publishedVersion | en |
dc.identifier.scopus | 2-s2.0-84855773005 |