A novel C,D-spirolactone analogue of paclitaxel: autophagy instead of apoptosis as a previously unknown mechanism of cytotoxic action for taxoids
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2012
Authors
Trmčić, MilenaMatović, Radomir
Tovilović, Gordana
Ristić, Biljana Z.
Trajković, Vladimir S.
Ferjančić, Zorana
Saičić, Radomir
Article (Published version)
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Show full item recordAbstract
The design, synthesis and biological evaluation of a novel C, D-spirolactone analogue of paclitaxel is described. This is the first paclitaxel analogue without an oxetane D-ring that shows a significant cytotoxic effect (activity one order of magnitude lower than paclitaxel). More importantly, its cytotoxicity is a result of a different mechanism of action, involving mTOR inhibition-dependent autophagy instead of G(2)/M cell cycle arrest-dependent apoptosis.
Source:
Organic and Biomolecular Chemistry, 2012, 10, 25, 4933-4942Publisher:
- Royal Soc Chemistry, Cambridge
Funding / projects:
- The development of new synthetic methods and their application in the synthesis of natural products and biologically active molecules (RS-MESTD-Basic Research (BR or ON)-172027)
- Modulation of intracellular energy balance-controlling signalling pathways in therapy of cancer and neuro-immuno-endocrine disorders (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41025)
Note:
- Supplementary material: http://cherry.chem.bg.ac.rs/handle/123456789/3673
DOI: 10.1039/c2ob25514f
ISSN: 1477-0520
PubMed: 22614284
WoS: 000304885200015
Scopus: 2-s2.0-84862224265
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Institution/Community
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Trmčić, Milena AU - Matović, Radomir AU - Tovilović, Gordana AU - Ristić, Biljana Z. AU - Trajković, Vladimir S. AU - Ferjančić, Zorana AU - Saičić, Radomir PY - 2012 UR - https://cherry.chem.bg.ac.rs/handle/123456789/1304 AB - The design, synthesis and biological evaluation of a novel C, D-spirolactone analogue of paclitaxel is described. This is the first paclitaxel analogue without an oxetane D-ring that shows a significant cytotoxic effect (activity one order of magnitude lower than paclitaxel). More importantly, its cytotoxicity is a result of a different mechanism of action, involving mTOR inhibition-dependent autophagy instead of G(2)/M cell cycle arrest-dependent apoptosis. PB - Royal Soc Chemistry, Cambridge T2 - Organic and Biomolecular Chemistry T1 - A novel C,D-spirolactone analogue of paclitaxel: autophagy instead of apoptosis as a previously unknown mechanism of cytotoxic action for taxoids VL - 10 IS - 25 SP - 4933 EP - 4942 DO - 10.1039/c2ob25514f ER -
@article{ author = "Trmčić, Milena and Matović, Radomir and Tovilović, Gordana and Ristić, Biljana Z. and Trajković, Vladimir S. and Ferjančić, Zorana and Saičić, Radomir", year = "2012", abstract = "The design, synthesis and biological evaluation of a novel C, D-spirolactone analogue of paclitaxel is described. This is the first paclitaxel analogue without an oxetane D-ring that shows a significant cytotoxic effect (activity one order of magnitude lower than paclitaxel). More importantly, its cytotoxicity is a result of a different mechanism of action, involving mTOR inhibition-dependent autophagy instead of G(2)/M cell cycle arrest-dependent apoptosis.", publisher = "Royal Soc Chemistry, Cambridge", journal = "Organic and Biomolecular Chemistry", title = "A novel C,D-spirolactone analogue of paclitaxel: autophagy instead of apoptosis as a previously unknown mechanism of cytotoxic action for taxoids", volume = "10", number = "25", pages = "4933-4942", doi = "10.1039/c2ob25514f" }
Trmčić, M., Matović, R., Tovilović, G., Ristić, B. Z., Trajković, V. S., Ferjančić, Z.,& Saičić, R.. (2012). A novel C,D-spirolactone analogue of paclitaxel: autophagy instead of apoptosis as a previously unknown mechanism of cytotoxic action for taxoids. in Organic and Biomolecular Chemistry Royal Soc Chemistry, Cambridge., 10(25), 4933-4942. https://doi.org/10.1039/c2ob25514f
Trmčić M, Matović R, Tovilović G, Ristić BZ, Trajković VS, Ferjančić Z, Saičić R. A novel C,D-spirolactone analogue of paclitaxel: autophagy instead of apoptosis as a previously unknown mechanism of cytotoxic action for taxoids. in Organic and Biomolecular Chemistry. 2012;10(25):4933-4942. doi:10.1039/c2ob25514f .
Trmčić, Milena, Matović, Radomir, Tovilović, Gordana, Ristić, Biljana Z., Trajković, Vladimir S., Ferjančić, Zorana, Saičić, Radomir, "A novel C,D-spirolactone analogue of paclitaxel: autophagy instead of apoptosis as a previously unknown mechanism of cytotoxic action for taxoids" in Organic and Biomolecular Chemistry, 10, no. 25 (2012):4933-4942, https://doi.org/10.1039/c2ob25514f . .