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Synthesis, characterization, DFT calculations and biological activity of derivatives of 3-acetylpyridine and the zinc(II) complex with the condensation product of 3-acetylpyridine and semicarbazide
dc.creator | Čobeljić, Božidar | |
dc.creator | Pevec, Andrej | |
dc.creator | Turel, Iztok | |
dc.creator | Swart, Marcel | |
dc.creator | Mitić, Dragana | |
dc.creator | Milenković, Marina | |
dc.creator | Marković, Ivanka | |
dc.creator | Jovanović, Maja | |
dc.creator | Sladić, Dušan | |
dc.creator | Jeremić, Marko | |
dc.creator | Anđelković, Katarina K. | |
dc.date.accessioned | 2018-11-22T00:23:24Z | |
dc.date.available | 2018-11-22T00:23:24Z | |
dc.date.issued | 2013 | |
dc.identifier.issn | 0020-1693 | |
dc.identifier.uri | https://cherry.chem.bg.ac.rs/handle/123456789/1367 | |
dc.description.abstract | A Schiff base of 3-acetylpyridine with semicarbazide as well as the corresponding tetrahedral Zn(II) complex were synthesized and characterized by X-ray crystal structure analysis and spectroscopic methods. It is interesting to note that the ligand coordinated as a monodentate although there are several donor atoms in it. Computational studies showed that such structure is more stable than the hypothetical structure with one ligand bound as a bidentate. The complex exibited moderate antibacterial, antifungal and cytotoxic activities while the ligand was mostly inactive. The complex strongly induced formation of reactive oxygen species in tumor cell lines. It also influenced cell cycle progression in tumor cell lines, and induced autophagy. The latter effect is, at least in part, a protective one. | en |
dc.publisher | Elsevier Science Sa, Lausanne | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172055/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41025/RS// | |
dc.relation | ICREA | |
dc.relation | Ministerio de Ciencia e Innovacion (MICINN) [CTQ2011-25086/BQU] | |
dc.relation | Slovenian Research Agency (ARRS) [P-0175] | |
dc.relation | MICINN (Ministry of Science and Innovation, Spain) | |
dc.relation | FEDER fund (European Fund for Regional Development) [UNGI08-4E-003] | |
dc.relation | DIUE of the Generalitat de Catalunya [2009SGR528] | |
dc.rights | restrictedAccess | |
dc.source | Inorganica Chimica Acta | |
dc.subject | Zn(II) complex | en |
dc.subject | Schiff base | en |
dc.subject | DFT calculations | en |
dc.subject | Biological activity | en |
dc.title | Synthesis, characterization, DFT calculations and biological activity of derivatives of 3-acetylpyridine and the zinc(II) complex with the condensation product of 3-acetylpyridine and semicarbazide | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Јовановиц, Маја; Aнђелковић, Катарина; Јеремић, Марко; Сладић, Душан; Чобељић, Божидар; Певец, Aндреј; Турел, Изток; Митиц, Драгана; Миленковиц, Марина; Сwарт, Марцел; Марковиц, Иванка; | |
dc.citation.volume | 404 | |
dc.citation.spage | 5 | |
dc.citation.epage | 12 | |
dc.identifier.wos | 000320651900002 | |
dc.identifier.doi | 10.1016/j.ica.2013.04.017 | |
dc.citation.other | 404: 5-12 | |
dc.citation.rank | M22 | |
dc.description.other | Peer-reviewed manuscript: [http://cherry.chem.bg.ac.rs/handle/123456789/3539] | |
dc.description.other | Supplementary material: [http://cherry.chem.bg.ac.rs/handle/123456789/3540] | |
dc.type.version | publishedVersion | en |
dc.identifier.scopus | 2-s2.0-84878219485 |