Platinum(II/IV) complexes containing ethylenediamine-N,N '-di-2/3-propionate ester ligands induced caspase-dependent apoptosis in cisplatin-resistant colon cancer cells
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2012
Authors
Kaluđerović, Goran N.Mijatovic, Sanja A.
Zmejkovski, Bojana B.
Bulatović, Mirna Z.
Gomez-Ruiz, Santiago
Mojic, Marija K.
Steinborn, Dirk
Miljkovic, Djordje M.
Schmidt, Harry
Stošić-Grujičić, Stanislava D.
Sabo, Tibor
Maksimovic-Ivanic, Danijela D.
Article (Published version)
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Several new R(2)eddp (R = i-Pr, i-Bu; eddp = ethylenediamine-N,N'-di-3-propionate) esters and corresponding platinum(II) and platinum(IV) complexes of the general formula [PtCln(R(2)edda-type)] (n = 2, 4) were synthesized and characterized by spectroscopic methods (IR, H-1 and C-13 NMR) and elemental analysis. The crystal structure of platinum(IV) complex [PtCl4{(c-Pe)(2)eddip}] (3a) was resolved and is given herein. Ligand precursors, platinum(II), and platinum(IV) complexes were tested against eight tumor cell lines (CT26CL25, HTC116, SW620, PC3, LNCaP, U251, A375, and B16). Selectivity in the action of those compounds between tumor and two normal primary cells (fibroblasts and keratinocytes) are discussed. A structure-activity relationship of these compounds is discussed. Furthermore, cell cycle distribution, induction of necrosis, apoptosis, autophagy, anoikis, caspase activation, ROS, and RNS are presented on the cisplatin-resistant colon carcinoma HCT116 cell line.
Source:
Metallomics, 2012, 4, 9, 979-987Publisher:
- Royal Soc Chemistry, Cambridge
Funding / projects:
- Rational design and synthesis of biologically active and coordination compounds and functional materials, relevant for (bio)nanotechnology (RS-MESTD-Basic Research (BR or ON)-172035)
- Molecular mechanisms of physiological and pharmacological control of inflammation and cancer (RS-MESTD-Basic Research (BR or ON)-173013)
- Alexander von Humboldt Foundation
DOI: 10.1039/c2mt20058a
ISSN: 1756-5901
PubMed: 22820831
WoS: 000307903700013
Scopus: 2-s2.0-84865492745
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Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Kaluđerović, Goran N. AU - Mijatovic, Sanja A. AU - Zmejkovski, Bojana B. AU - Bulatović, Mirna Z. AU - Gomez-Ruiz, Santiago AU - Mojic, Marija K. AU - Steinborn, Dirk AU - Miljkovic, Djordje M. AU - Schmidt, Harry AU - Stošić-Grujičić, Stanislava D. AU - Sabo, Tibor AU - Maksimovic-Ivanic, Danijela D. PY - 2012 UR - https://cherry.chem.bg.ac.rs/handle/123456789/1523 AB - Several new R(2)eddp (R = i-Pr, i-Bu; eddp = ethylenediamine-N,N'-di-3-propionate) esters and corresponding platinum(II) and platinum(IV) complexes of the general formula [PtCln(R(2)edda-type)] (n = 2, 4) were synthesized and characterized by spectroscopic methods (IR, H-1 and C-13 NMR) and elemental analysis. The crystal structure of platinum(IV) complex [PtCl4{(c-Pe)(2)eddip}] (3a) was resolved and is given herein. Ligand precursors, platinum(II), and platinum(IV) complexes were tested against eight tumor cell lines (CT26CL25, HTC116, SW620, PC3, LNCaP, U251, A375, and B16). Selectivity in the action of those compounds between tumor and two normal primary cells (fibroblasts and keratinocytes) are discussed. A structure-activity relationship of these compounds is discussed. Furthermore, cell cycle distribution, induction of necrosis, apoptosis, autophagy, anoikis, caspase activation, ROS, and RNS are presented on the cisplatin-resistant colon carcinoma HCT116 cell line. PB - Royal Soc Chemistry, Cambridge T2 - Metallomics T1 - Platinum(II/IV) complexes containing ethylenediamine-N,N '-di-2/3-propionate ester ligands induced caspase-dependent apoptosis in cisplatin-resistant colon cancer cells VL - 4 IS - 9 SP - 979 EP - 987 DO - 10.1039/c2mt20058a ER -
@article{ author = "Kaluđerović, Goran N. and Mijatovic, Sanja A. and Zmejkovski, Bojana B. and Bulatović, Mirna Z. and Gomez-Ruiz, Santiago and Mojic, Marija K. and Steinborn, Dirk and Miljkovic, Djordje M. and Schmidt, Harry and Stošić-Grujičić, Stanislava D. and Sabo, Tibor and Maksimovic-Ivanic, Danijela D.", year = "2012", abstract = "Several new R(2)eddp (R = i-Pr, i-Bu; eddp = ethylenediamine-N,N'-di-3-propionate) esters and corresponding platinum(II) and platinum(IV) complexes of the general formula [PtCln(R(2)edda-type)] (n = 2, 4) were synthesized and characterized by spectroscopic methods (IR, H-1 and C-13 NMR) and elemental analysis. The crystal structure of platinum(IV) complex [PtCl4{(c-Pe)(2)eddip}] (3a) was resolved and is given herein. Ligand precursors, platinum(II), and platinum(IV) complexes were tested against eight tumor cell lines (CT26CL25, HTC116, SW620, PC3, LNCaP, U251, A375, and B16). Selectivity in the action of those compounds between tumor and two normal primary cells (fibroblasts and keratinocytes) are discussed. A structure-activity relationship of these compounds is discussed. Furthermore, cell cycle distribution, induction of necrosis, apoptosis, autophagy, anoikis, caspase activation, ROS, and RNS are presented on the cisplatin-resistant colon carcinoma HCT116 cell line.", publisher = "Royal Soc Chemistry, Cambridge", journal = "Metallomics", title = "Platinum(II/IV) complexes containing ethylenediamine-N,N '-di-2/3-propionate ester ligands induced caspase-dependent apoptosis in cisplatin-resistant colon cancer cells", volume = "4", number = "9", pages = "979-987", doi = "10.1039/c2mt20058a" }
Kaluđerović, G. N., Mijatovic, S. A., Zmejkovski, B. B., Bulatović, M. Z., Gomez-Ruiz, S., Mojic, M. K., Steinborn, D., Miljkovic, D. M., Schmidt, H., Stošić-Grujičić, S. D., Sabo, T.,& Maksimovic-Ivanic, D. D.. (2012). Platinum(II/IV) complexes containing ethylenediamine-N,N '-di-2/3-propionate ester ligands induced caspase-dependent apoptosis in cisplatin-resistant colon cancer cells. in Metallomics Royal Soc Chemistry, Cambridge., 4(9), 979-987. https://doi.org/10.1039/c2mt20058a
Kaluđerović GN, Mijatovic SA, Zmejkovski BB, Bulatović MZ, Gomez-Ruiz S, Mojic MK, Steinborn D, Miljkovic DM, Schmidt H, Stošić-Grujičić SD, Sabo T, Maksimovic-Ivanic DD. Platinum(II/IV) complexes containing ethylenediamine-N,N '-di-2/3-propionate ester ligands induced caspase-dependent apoptosis in cisplatin-resistant colon cancer cells. in Metallomics. 2012;4(9):979-987. doi:10.1039/c2mt20058a .
Kaluđerović, Goran N., Mijatovic, Sanja A., Zmejkovski, Bojana B., Bulatović, Mirna Z., Gomez-Ruiz, Santiago, Mojic, Marija K., Steinborn, Dirk, Miljkovic, Djordje M., Schmidt, Harry, Stošić-Grujičić, Stanislava D., Sabo, Tibor, Maksimovic-Ivanic, Danijela D., "Platinum(II/IV) complexes containing ethylenediamine-N,N '-di-2/3-propionate ester ligands induced caspase-dependent apoptosis in cisplatin-resistant colon cancer cells" in Metallomics, 4, no. 9 (2012):979-987, https://doi.org/10.1039/c2mt20058a . .