Anti-metastatic and Anti-angiogenic Properties of Potential New Anti-cancer Drugs Based on Metal Complexes of Selenosemicarbazones
Nema prikaza
Autori
Zec, ManjaSrdić-Rajić, Tatjana
Konic-Ristic, Aleksandra
Todorović, Tamara
Anđelković, Katarina K.
Filipovic-Ljeskovic, Ivana
Radulović, Siniša
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Our previous studies showed that zinc (II), cadmium (II) and nickel (II) complexes with 2-formylpyridine selenose-micarbazone induce apoptosis in cancer cells via activation of mitochondrial pathway. Herein, we reported their antimetastatic properties. Nickel (II), and zinc (II) complexes exhibited the strongest inhibitory potential towards MMP-2/9, while all investigated compounds significantly decreased proteolytic activity of MMP-2/9 in human breast cancer MDA-MB-361 cells. As shown by in vitro transmembrane assays, nickel (II) complex was the most effective in inhibiting invasion of MDA-MB-361 cells, while the cadmium (II) complex was the most active in inhibiting HeLa cells invasion. In malignant cells, the complexes inhibited intracellular accumulation of reactive oxygen species, known for its pro-angiogenic properties via VEGF signaling, but no reduction in total cellular amount of VEGF was found. Furthermore, tubulogenesis test showed anti-angiogenic effect of the complexes in ...treated endothelial cells. Data indicate multiple mechanisms of the complexes' anti-angiogenic properties. In addition, they could modulate metastatic phenotype of tumor cells. Nickel (II) complex with 2-formylpyridine selenosemicarbazone revealed to be the most potent.
Ključne reči:
Antiangiogenic potential / Antiinvasive potential / Antimetastatic potential / Cadmium / Cisplatin / Matrix-metalloproteinase / Metal complexes / Metastasis / Nickel / Oncology / Reactive oxygen species / SelenoIzvor:
Anti-Cancer Agents in Medicinal Chemistry, 2012, 12, 9, 1071-1080Izdavač:
- Bentham Science Publ Ltd, Sharjah
Finansiranje / projekti:
- Farmakodinamska i farmakogenomska ispitivanja novijih lekova u lečenju solidnih tumora (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41026)
- Interakcije prirodnih proizvoda, njihovih derivata i kompleksnih jedinjenja sa proteinima i nukleinskim kiselinama (RS-MESTD-Basic Research (BR or ON)-172055)
DOI: 10.2174/187152012803529682
ISSN: 1871-5206
PubMed: 22583413
WoS: 000310055000006
Scopus: 2-s2.0-84872258038
Kolekcije
Institucija/grupa
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Zec, Manja AU - Srdić-Rajić, Tatjana AU - Konic-Ristic, Aleksandra AU - Todorović, Tamara AU - Anđelković, Katarina K. AU - Filipovic-Ljeskovic, Ivana AU - Radulović, Siniša PY - 2012 UR - https://cherry.chem.bg.ac.rs/handle/123456789/1539 AB - Our previous studies showed that zinc (II), cadmium (II) and nickel (II) complexes with 2-formylpyridine selenose-micarbazone induce apoptosis in cancer cells via activation of mitochondrial pathway. Herein, we reported their antimetastatic properties. Nickel (II), and zinc (II) complexes exhibited the strongest inhibitory potential towards MMP-2/9, while all investigated compounds significantly decreased proteolytic activity of MMP-2/9 in human breast cancer MDA-MB-361 cells. As shown by in vitro transmembrane assays, nickel (II) complex was the most effective in inhibiting invasion of MDA-MB-361 cells, while the cadmium (II) complex was the most active in inhibiting HeLa cells invasion. In malignant cells, the complexes inhibited intracellular accumulation of reactive oxygen species, known for its pro-angiogenic properties via VEGF signaling, but no reduction in total cellular amount of VEGF was found. Furthermore, tubulogenesis test showed anti-angiogenic effect of the complexes in treated endothelial cells. Data indicate multiple mechanisms of the complexes' anti-angiogenic properties. In addition, they could modulate metastatic phenotype of tumor cells. Nickel (II) complex with 2-formylpyridine selenosemicarbazone revealed to be the most potent. PB - Bentham Science Publ Ltd, Sharjah T2 - Anti-Cancer Agents in Medicinal Chemistry T1 - Anti-metastatic and Anti-angiogenic Properties of Potential New Anti-cancer Drugs Based on Metal Complexes of Selenosemicarbazones VL - 12 IS - 9 SP - 1071 EP - 1080 DO - 10.2174/187152012803529682 ER -
@article{ author = "Zec, Manja and Srdić-Rajić, Tatjana and Konic-Ristic, Aleksandra and Todorović, Tamara and Anđelković, Katarina K. and Filipovic-Ljeskovic, Ivana and Radulović, Siniša", year = "2012", abstract = "Our previous studies showed that zinc (II), cadmium (II) and nickel (II) complexes with 2-formylpyridine selenose-micarbazone induce apoptosis in cancer cells via activation of mitochondrial pathway. Herein, we reported their antimetastatic properties. Nickel (II), and zinc (II) complexes exhibited the strongest inhibitory potential towards MMP-2/9, while all investigated compounds significantly decreased proteolytic activity of MMP-2/9 in human breast cancer MDA-MB-361 cells. As shown by in vitro transmembrane assays, nickel (II) complex was the most effective in inhibiting invasion of MDA-MB-361 cells, while the cadmium (II) complex was the most active in inhibiting HeLa cells invasion. In malignant cells, the complexes inhibited intracellular accumulation of reactive oxygen species, known for its pro-angiogenic properties via VEGF signaling, but no reduction in total cellular amount of VEGF was found. Furthermore, tubulogenesis test showed anti-angiogenic effect of the complexes in treated endothelial cells. Data indicate multiple mechanisms of the complexes' anti-angiogenic properties. In addition, they could modulate metastatic phenotype of tumor cells. Nickel (II) complex with 2-formylpyridine selenosemicarbazone revealed to be the most potent.", publisher = "Bentham Science Publ Ltd, Sharjah", journal = "Anti-Cancer Agents in Medicinal Chemistry", title = "Anti-metastatic and Anti-angiogenic Properties of Potential New Anti-cancer Drugs Based on Metal Complexes of Selenosemicarbazones", volume = "12", number = "9", pages = "1071-1080", doi = "10.2174/187152012803529682" }
Zec, M., Srdić-Rajić, T., Konic-Ristic, A., Todorović, T., Anđelković, K. K., Filipovic-Ljeskovic, I.,& Radulović, S.. (2012). Anti-metastatic and Anti-angiogenic Properties of Potential New Anti-cancer Drugs Based on Metal Complexes of Selenosemicarbazones. in Anti-Cancer Agents in Medicinal Chemistry Bentham Science Publ Ltd, Sharjah., 12(9), 1071-1080. https://doi.org/10.2174/187152012803529682
Zec M, Srdić-Rajić T, Konic-Ristic A, Todorović T, Anđelković KK, Filipovic-Ljeskovic I, Radulović S. Anti-metastatic and Anti-angiogenic Properties of Potential New Anti-cancer Drugs Based on Metal Complexes of Selenosemicarbazones. in Anti-Cancer Agents in Medicinal Chemistry. 2012;12(9):1071-1080. doi:10.2174/187152012803529682 .
Zec, Manja, Srdić-Rajić, Tatjana, Konic-Ristic, Aleksandra, Todorović, Tamara, Anđelković, Katarina K., Filipovic-Ljeskovic, Ivana, Radulović, Siniša, "Anti-metastatic and Anti-angiogenic Properties of Potential New Anti-cancer Drugs Based on Metal Complexes of Selenosemicarbazones" in Anti-Cancer Agents in Medicinal Chemistry, 12, no. 9 (2012):1071-1080, https://doi.org/10.2174/187152012803529682 . .