Toxicity of oral cadmium intake: Impact on gut immunity
Samo za registrovane korisnike
2015
Autori
Ninkov, MarinaPopov-Aleksandrov, Aleksandra
Demenesku, Jelena
Mirkov, Ivana
Mileusnić, Dina
Petrović, Anja
Grigorov, Ilijana
Zolotarevski, Lidija
Tolinački, Maja
Kataranovski, Dragan
Brčeski, Ilija
Kataranovski, Milena
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Gastrointestinal tract is one of the main targets of cadmium (Cd), an important food and drinking water contaminant. In the present study, the effect of subchronic (30 days) oral (in water) intake of 5ppm and 50ppm of cadmium on immune responses in the gut was examined in rats. Cadmium consumption resulted in reduction of bacteria corresponding to Lactobacillus strain, tissue damage and intestinal inflammation [increases in high mobility group box 1 (HMGB1 molecules), superoxide dismutase (SOD) and catalase (CAT) activity and proinflammatory cytokine (TNF, IL-1 beta, IFN-gamma, IL-17) content]. Draining (mesenteric) lymph node (MLN) stress response was observed [elevation of MLN glutathione (GSH) and metallothionein (MT) mRNA levels] and stimulation of both adaptive [cellularity, proliferation, proinflammatory (IFN-gamma and IL-17) MLN cell cytokine responses] as well as innate immune activity (increases in numbers of NK and CD68(+) cells, oxidative activities, IL-1 beta). In contrast ...to proinflammatory milieu in MLN, decreased or unchanged antiinflammatory IL-10 response was observed. Stimulation of immune activities of MLN cells have, most probably, resulted from sensing of cadmium-induced tissue injury, but also from bacterial antigens that breached compromised intestinal barrier. These effects of cadmium should be taken into account when assessing dietary cadmium as health risk factor. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
Ključne reči:
Oral cadmium intake / Rats / Intestinal (duodenum) inflammation / Mesenteric lymph nodes immune primingIzvor:
Toxicology Letters, 2015, 237, 2, 89-99Izdavač:
- Elsevier Ireland Ltd, Clare
Finansiranje / projekti:
- Imunomodulatorni efekti ksenobiotika i biotičkih faktora životne sredine na populacije mišolikih glodara (RS-MESTD-Basic Research (BR or ON)-173039)
DOI: 10.1016/j.toxlet.2015.06.002
ISSN: 0378-4274
PubMed: 26051590
WoS: 000357391500004
Scopus: 2-s2.0-84931264431
Kolekcije
Institucija/grupa
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Ninkov, Marina AU - Popov-Aleksandrov, Aleksandra AU - Demenesku, Jelena AU - Mirkov, Ivana AU - Mileusnić, Dina AU - Petrović, Anja AU - Grigorov, Ilijana AU - Zolotarevski, Lidija AU - Tolinački, Maja AU - Kataranovski, Dragan AU - Brčeski, Ilija AU - Kataranovski, Milena PY - 2015 UR - https://cherry.chem.bg.ac.rs/handle/123456789/1730 AB - Gastrointestinal tract is one of the main targets of cadmium (Cd), an important food and drinking water contaminant. In the present study, the effect of subchronic (30 days) oral (in water) intake of 5ppm and 50ppm of cadmium on immune responses in the gut was examined in rats. Cadmium consumption resulted in reduction of bacteria corresponding to Lactobacillus strain, tissue damage and intestinal inflammation [increases in high mobility group box 1 (HMGB1 molecules), superoxide dismutase (SOD) and catalase (CAT) activity and proinflammatory cytokine (TNF, IL-1 beta, IFN-gamma, IL-17) content]. Draining (mesenteric) lymph node (MLN) stress response was observed [elevation of MLN glutathione (GSH) and metallothionein (MT) mRNA levels] and stimulation of both adaptive [cellularity, proliferation, proinflammatory (IFN-gamma and IL-17) MLN cell cytokine responses] as well as innate immune activity (increases in numbers of NK and CD68(+) cells, oxidative activities, IL-1 beta). In contrast to proinflammatory milieu in MLN, decreased or unchanged antiinflammatory IL-10 response was observed. Stimulation of immune activities of MLN cells have, most probably, resulted from sensing of cadmium-induced tissue injury, but also from bacterial antigens that breached compromised intestinal barrier. These effects of cadmium should be taken into account when assessing dietary cadmium as health risk factor. (C) 2015 Elsevier Ireland Ltd. All rights reserved. PB - Elsevier Ireland Ltd, Clare T2 - Toxicology Letters T1 - Toxicity of oral cadmium intake: Impact on gut immunity VL - 237 IS - 2 SP - 89 EP - 99 DO - 10.1016/j.toxlet.2015.06.002 ER -
@article{ author = "Ninkov, Marina and Popov-Aleksandrov, Aleksandra and Demenesku, Jelena and Mirkov, Ivana and Mileusnić, Dina and Petrović, Anja and Grigorov, Ilijana and Zolotarevski, Lidija and Tolinački, Maja and Kataranovski, Dragan and Brčeski, Ilija and Kataranovski, Milena", year = "2015", abstract = "Gastrointestinal tract is one of the main targets of cadmium (Cd), an important food and drinking water contaminant. In the present study, the effect of subchronic (30 days) oral (in water) intake of 5ppm and 50ppm of cadmium on immune responses in the gut was examined in rats. Cadmium consumption resulted in reduction of bacteria corresponding to Lactobacillus strain, tissue damage and intestinal inflammation [increases in high mobility group box 1 (HMGB1 molecules), superoxide dismutase (SOD) and catalase (CAT) activity and proinflammatory cytokine (TNF, IL-1 beta, IFN-gamma, IL-17) content]. Draining (mesenteric) lymph node (MLN) stress response was observed [elevation of MLN glutathione (GSH) and metallothionein (MT) mRNA levels] and stimulation of both adaptive [cellularity, proliferation, proinflammatory (IFN-gamma and IL-17) MLN cell cytokine responses] as well as innate immune activity (increases in numbers of NK and CD68(+) cells, oxidative activities, IL-1 beta). In contrast to proinflammatory milieu in MLN, decreased or unchanged antiinflammatory IL-10 response was observed. Stimulation of immune activities of MLN cells have, most probably, resulted from sensing of cadmium-induced tissue injury, but also from bacterial antigens that breached compromised intestinal barrier. These effects of cadmium should be taken into account when assessing dietary cadmium as health risk factor. (C) 2015 Elsevier Ireland Ltd. All rights reserved.", publisher = "Elsevier Ireland Ltd, Clare", journal = "Toxicology Letters", title = "Toxicity of oral cadmium intake: Impact on gut immunity", volume = "237", number = "2", pages = "89-99", doi = "10.1016/j.toxlet.2015.06.002" }
Ninkov, M., Popov-Aleksandrov, A., Demenesku, J., Mirkov, I., Mileusnić, D., Petrović, A., Grigorov, I., Zolotarevski, L., Tolinački, M., Kataranovski, D., Brčeski, I.,& Kataranovski, M.. (2015). Toxicity of oral cadmium intake: Impact on gut immunity. in Toxicology Letters Elsevier Ireland Ltd, Clare., 237(2), 89-99. https://doi.org/10.1016/j.toxlet.2015.06.002
Ninkov M, Popov-Aleksandrov A, Demenesku J, Mirkov I, Mileusnić D, Petrović A, Grigorov I, Zolotarevski L, Tolinački M, Kataranovski D, Brčeski I, Kataranovski M. Toxicity of oral cadmium intake: Impact on gut immunity. in Toxicology Letters. 2015;237(2):89-99. doi:10.1016/j.toxlet.2015.06.002 .
Ninkov, Marina, Popov-Aleksandrov, Aleksandra, Demenesku, Jelena, Mirkov, Ivana, Mileusnić, Dina, Petrović, Anja, Grigorov, Ilijana, Zolotarevski, Lidija, Tolinački, Maja, Kataranovski, Dragan, Brčeski, Ilija, Kataranovski, Milena, "Toxicity of oral cadmium intake: Impact on gut immunity" in Toxicology Letters, 237, no. 2 (2015):89-99, https://doi.org/10.1016/j.toxlet.2015.06.002 . .