Biological activity of two isomeric N-heteroaromatic selenosemicarbazones and their metal complexes
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2014
Authors
Filipović, Nenad R.Polović, Natalija
Rašković, Brankica
Misirlić-Denčić, Sonja
Dulović, Marija
Savić, Milena
Nikšić, Miomir
Mitić, Dragana
Anđelković, Katarina K.
Todorović, Tamara
Article (Published version)
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Show full item recordAbstract
New square-planar Pd(II) and Pt(II) complexes with 8-quinolinecarboxaldehyde selenosemicarbazone have been synthesized and characterized by use of elemental analysis, molar conductivity measurements, and IR and NMR spectroscopy. The cytotoxic activity of the ligand, new Pt(II) and Pd(II) compounds, and previously synthesized Pd(II), Pt(II), Cd(II), and Ni(II) complexes with the analogous ligand, 2-quinolinecarboxaldehyde selenosemicarbazone, was tested against two human cancer cell lines: lung carcinoma (H460) and glioma (U251). The potential of these compounds to induce perturbations of the H460 cell cycle was also evaluated. These substances had an excellent radical-scavenging effect against ABTS radical cations. The best antimicrobial activity, among two yeasts and eight bacterial strains tested, was against Bacillus cereus.
Keywords:
Antimicrobial activity / Antioxidants / Cytotoxicity / Coordination chemistry / Schiff basesSource:
Monatshefte Fur Chemie, 2014, 145, 7, 1089-1099Publisher:
- Springer Wien, Wien
Funding / projects:
- Interactions of natural products, their derivatives and coordination compounds with proteins and nucleic acids (RS-MESTD-Basic Research (BR or ON)-172055)
- Modulation of intracellular energy balance-controlling signalling pathways in therapy of cancer and neuro-immuno-endocrine disorders (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41025)
- Novel encapsulation and enzyme technologies for designing of new biocatalysts and biologically active compounds targeting enhancement of food quality, safety and competitiveness (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-46010)
Note:
- Supplementary material: http://cherry.chem.bg.ac.rs/handle/123456789/3683
DOI: 10.1007/s00706-014-1197-6
ISSN: 0026-9247
WoS: 000337046200006
Scopus: 2-s2.0-84902270174
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Institution/Community
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Filipović, Nenad R. AU - Polović, Natalija AU - Rašković, Brankica AU - Misirlić-Denčić, Sonja AU - Dulović, Marija AU - Savić, Milena AU - Nikšić, Miomir AU - Mitić, Dragana AU - Anđelković, Katarina K. AU - Todorović, Tamara PY - 2014 UR - https://cherry.chem.bg.ac.rs/handle/123456789/1787 AB - New square-planar Pd(II) and Pt(II) complexes with 8-quinolinecarboxaldehyde selenosemicarbazone have been synthesized and characterized by use of elemental analysis, molar conductivity measurements, and IR and NMR spectroscopy. The cytotoxic activity of the ligand, new Pt(II) and Pd(II) compounds, and previously synthesized Pd(II), Pt(II), Cd(II), and Ni(II) complexes with the analogous ligand, 2-quinolinecarboxaldehyde selenosemicarbazone, was tested against two human cancer cell lines: lung carcinoma (H460) and glioma (U251). The potential of these compounds to induce perturbations of the H460 cell cycle was also evaluated. These substances had an excellent radical-scavenging effect against ABTS radical cations. The best antimicrobial activity, among two yeasts and eight bacterial strains tested, was against Bacillus cereus. PB - Springer Wien, Wien T2 - Monatshefte Fur Chemie T1 - Biological activity of two isomeric N-heteroaromatic selenosemicarbazones and their metal complexes VL - 145 IS - 7 SP - 1089 EP - 1099 DO - 10.1007/s00706-014-1197-6 ER -
@article{ author = "Filipović, Nenad R. and Polović, Natalija and Rašković, Brankica and Misirlić-Denčić, Sonja and Dulović, Marija and Savić, Milena and Nikšić, Miomir and Mitić, Dragana and Anđelković, Katarina K. and Todorović, Tamara", year = "2014", abstract = "New square-planar Pd(II) and Pt(II) complexes with 8-quinolinecarboxaldehyde selenosemicarbazone have been synthesized and characterized by use of elemental analysis, molar conductivity measurements, and IR and NMR spectroscopy. The cytotoxic activity of the ligand, new Pt(II) and Pd(II) compounds, and previously synthesized Pd(II), Pt(II), Cd(II), and Ni(II) complexes with the analogous ligand, 2-quinolinecarboxaldehyde selenosemicarbazone, was tested against two human cancer cell lines: lung carcinoma (H460) and glioma (U251). The potential of these compounds to induce perturbations of the H460 cell cycle was also evaluated. These substances had an excellent radical-scavenging effect against ABTS radical cations. The best antimicrobial activity, among two yeasts and eight bacterial strains tested, was against Bacillus cereus.", publisher = "Springer Wien, Wien", journal = "Monatshefte Fur Chemie", title = "Biological activity of two isomeric N-heteroaromatic selenosemicarbazones and their metal complexes", volume = "145", number = "7", pages = "1089-1099", doi = "10.1007/s00706-014-1197-6" }
Filipović, N. R., Polović, N., Rašković, B., Misirlić-Denčić, S., Dulović, M., Savić, M., Nikšić, M., Mitić, D., Anđelković, K. K.,& Todorović, T.. (2014). Biological activity of two isomeric N-heteroaromatic selenosemicarbazones and their metal complexes. in Monatshefte Fur Chemie Springer Wien, Wien., 145(7), 1089-1099. https://doi.org/10.1007/s00706-014-1197-6
Filipović NR, Polović N, Rašković B, Misirlić-Denčić S, Dulović M, Savić M, Nikšić M, Mitić D, Anđelković KK, Todorović T. Biological activity of two isomeric N-heteroaromatic selenosemicarbazones and their metal complexes. in Monatshefte Fur Chemie. 2014;145(7):1089-1099. doi:10.1007/s00706-014-1197-6 .
Filipović, Nenad R., Polović, Natalija, Rašković, Brankica, Misirlić-Denčić, Sonja, Dulović, Marija, Savić, Milena, Nikšić, Miomir, Mitić, Dragana, Anđelković, Katarina K., Todorović, Tamara, "Biological activity of two isomeric N-heteroaromatic selenosemicarbazones and their metal complexes" in Monatshefte Fur Chemie, 145, no. 7 (2014):1089-1099, https://doi.org/10.1007/s00706-014-1197-6 . .