Sensitive and selective determination of riboflavin (vitamin B2) based on boron-doped diamond electrode
Abstract
In this paper, we present electrochemical behavior and determination of riboflavin in pharmaceutical tablets by square wave voltammetry using unmodified boron-doped diamond electrode. In Britton-Robinson buffer solution at pH 2, by employing cyclic voltammetry it is demonstrated that riboflavin undergoes a diffusion-controlled quasi-reversible electron transfer reaction. The experimental parameters, such as pH of the supporting electrolyte, square wave voltammetry parameters, influence of most common interferences, were examined. Under optimized experimental conditions in Britton-Robinson buffer solution at pH 2, linear calibration curves were obtained in the wide range from 0.02 to 35 A mu M, with the capability of detection of 0.0037 A mu M. Repeatability of ten measurements was calculated at four concentrations from linear range and all values were lt 1.8 %. Proposed method was successfully applied for the determination of the total vitamin content in pharmaceutical preparations a...nd urine samples. The developed approach could be beneficial for the quantification of vitamin in drugs using boron-doped diamond electrode as up-to-date electrochemical sensor and could represent inexpensive analytical alternative to separation methods.
Keywords:
Electrochemistry / Sensors / Drug research / Boron-doped diamond electrodeSource:
Monatshefte Fur Chemie, 2016, 147, 6, 995-1000Publisher:
- Springer Wien, Wien
Funding / projects:
- Application of advanced oxidation processes and nanostructured oxide materials for the removal of pollutants from the environment, development and optimisation of instrumental techniques for efficiency monitoring (RS-MESTD-Basic Research (BR or ON)-172030)
DOI: 10.1007/s00706-016-1665-2
ISSN: 0026-9247
WoS: 000376070500003
Scopus: 2-s2.0-85027942779
Collections
Institution/Community
Inovacioni centar / Innovation CentreTY - JOUR AU - Stanković, Dalibor AU - Kuzmanović, Darko AU - Mehmeti, Eda AU - Kalcher, Kurt PY - 2016 UR - https://cherry.chem.bg.ac.rs/handle/123456789/1936 AB - In this paper, we present electrochemical behavior and determination of riboflavin in pharmaceutical tablets by square wave voltammetry using unmodified boron-doped diamond electrode. In Britton-Robinson buffer solution at pH 2, by employing cyclic voltammetry it is demonstrated that riboflavin undergoes a diffusion-controlled quasi-reversible electron transfer reaction. The experimental parameters, such as pH of the supporting electrolyte, square wave voltammetry parameters, influence of most common interferences, were examined. Under optimized experimental conditions in Britton-Robinson buffer solution at pH 2, linear calibration curves were obtained in the wide range from 0.02 to 35 A mu M, with the capability of detection of 0.0037 A mu M. Repeatability of ten measurements was calculated at four concentrations from linear range and all values were lt 1.8 %. Proposed method was successfully applied for the determination of the total vitamin content in pharmaceutical preparations and urine samples. The developed approach could be beneficial for the quantification of vitamin in drugs using boron-doped diamond electrode as up-to-date electrochemical sensor and could represent inexpensive analytical alternative to separation methods. PB - Springer Wien, Wien T2 - Monatshefte Fur Chemie T1 - Sensitive and selective determination of riboflavin (vitamin B2) based on boron-doped diamond electrode VL - 147 IS - 6 SP - 995 EP - 1000 DO - 10.1007/s00706-016-1665-2 ER -
@article{ author = "Stanković, Dalibor and Kuzmanović, Darko and Mehmeti, Eda and Kalcher, Kurt", year = "2016", abstract = "In this paper, we present electrochemical behavior and determination of riboflavin in pharmaceutical tablets by square wave voltammetry using unmodified boron-doped diamond electrode. In Britton-Robinson buffer solution at pH 2, by employing cyclic voltammetry it is demonstrated that riboflavin undergoes a diffusion-controlled quasi-reversible electron transfer reaction. The experimental parameters, such as pH of the supporting electrolyte, square wave voltammetry parameters, influence of most common interferences, were examined. Under optimized experimental conditions in Britton-Robinson buffer solution at pH 2, linear calibration curves were obtained in the wide range from 0.02 to 35 A mu M, with the capability of detection of 0.0037 A mu M. Repeatability of ten measurements was calculated at four concentrations from linear range and all values were lt 1.8 %. Proposed method was successfully applied for the determination of the total vitamin content in pharmaceutical preparations and urine samples. The developed approach could be beneficial for the quantification of vitamin in drugs using boron-doped diamond electrode as up-to-date electrochemical sensor and could represent inexpensive analytical alternative to separation methods.", publisher = "Springer Wien, Wien", journal = "Monatshefte Fur Chemie", title = "Sensitive and selective determination of riboflavin (vitamin B2) based on boron-doped diamond electrode", volume = "147", number = "6", pages = "995-1000", doi = "10.1007/s00706-016-1665-2" }
Stanković, D., Kuzmanović, D., Mehmeti, E.,& Kalcher, K.. (2016). Sensitive and selective determination of riboflavin (vitamin B2) based on boron-doped diamond electrode. in Monatshefte Fur Chemie Springer Wien, Wien., 147(6), 995-1000. https://doi.org/10.1007/s00706-016-1665-2
Stanković D, Kuzmanović D, Mehmeti E, Kalcher K. Sensitive and selective determination of riboflavin (vitamin B2) based on boron-doped diamond electrode. in Monatshefte Fur Chemie. 2016;147(6):995-1000. doi:10.1007/s00706-016-1665-2 .
Stanković, Dalibor, Kuzmanović, Darko, Mehmeti, Eda, Kalcher, Kurt, "Sensitive and selective determination of riboflavin (vitamin B2) based on boron-doped diamond electrode" in Monatshefte Fur Chemie, 147, no. 6 (2016):995-1000, https://doi.org/10.1007/s00706-016-1665-2 . .