Total Synthesis of (+/-)-Alstoscholarisine A
Abstract
The first total synthesis of the neuroactive indole alkaloid (+/-)-alstoscholarisine A is reported. The key step of the concise synthesis is an efficient domino sequence that was used to assemble the 2,8-diazabicyclo[3.3.1]nonane core through the formation of two C-N bonds and one C-C bond in a single step.
Keywords:
alkaloids / alstoscholarisine / domino reactions / natural products / total synthesisSource:
Angewandte Chemie (International Edition), 2016, 55, 7, 2569-2572Publisher:
- Wiley-V C H Verlag Gmbh, Weinheim
Funding / projects:
- The development of new synthetic methods and their application in the synthesis of natural products and biologically active molecules (RS-MESTD-Basic Research (BR or ON)-172027)
Note:
- Supplementary material: http://cherry.chem.bg.ac.rs/handle/123456789/3655
DOI: 10.1002/anie.201510777
ISSN: 1433-7851
PubMed: 26757206
WoS: 000369970500051
Scopus: 2-s2.0-84954109292
Collections
Institution/Community
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Bihelović, Filip AU - Ferjančić, Zorana PY - 2016 UR - https://cherry.chem.bg.ac.rs/handle/123456789/2048 AB - The first total synthesis of the neuroactive indole alkaloid (+/-)-alstoscholarisine A is reported. The key step of the concise synthesis is an efficient domino sequence that was used to assemble the 2,8-diazabicyclo[3.3.1]nonane core through the formation of two C-N bonds and one C-C bond in a single step. PB - Wiley-V C H Verlag Gmbh, Weinheim T2 - Angewandte Chemie (International Edition) T1 - Total Synthesis of (+/-)-Alstoscholarisine A VL - 55 IS - 7 SP - 2569 EP - 2572 DO - 10.1002/anie.201510777 ER -
@article{ author = "Bihelović, Filip and Ferjančić, Zorana", year = "2016", abstract = "The first total synthesis of the neuroactive indole alkaloid (+/-)-alstoscholarisine A is reported. The key step of the concise synthesis is an efficient domino sequence that was used to assemble the 2,8-diazabicyclo[3.3.1]nonane core through the formation of two C-N bonds and one C-C bond in a single step.", publisher = "Wiley-V C H Verlag Gmbh, Weinheim", journal = "Angewandte Chemie (International Edition)", title = "Total Synthesis of (+/-)-Alstoscholarisine A", volume = "55", number = "7", pages = "2569-2572", doi = "10.1002/anie.201510777" }
Bihelović, F.,& Ferjančić, Z.. (2016). Total Synthesis of (+/-)-Alstoscholarisine A. in Angewandte Chemie (International Edition) Wiley-V C H Verlag Gmbh, Weinheim., 55(7), 2569-2572. https://doi.org/10.1002/anie.201510777
Bihelović F, Ferjančić Z. Total Synthesis of (+/-)-Alstoscholarisine A. in Angewandte Chemie (International Edition). 2016;55(7):2569-2572. doi:10.1002/anie.201510777 .
Bihelović, Filip, Ferjančić, Zorana, "Total Synthesis of (+/-)-Alstoscholarisine A" in Angewandte Chemie (International Edition), 55, no. 7 (2016):2569-2572, https://doi.org/10.1002/anie.201510777 . .