Trametes versicolor ethanol extract, a promising candidate for health-promoting food supplement
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2018
Authors
Janjušević, LjiljanaPejin, Boris
Kaišarević, Sonja
Gorjanović, Stanislava
Pastor, Ferenc
Tešanović, Kristina
Karaman, Maja
Article (Published version)
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Show full item recordAbstract
This study aimed to estimate antiradical, antioxidant (AO) and cytotoxic activities of the fungus Trametes versicolor ethanol fruiting body extract. The extract was found to effectively scavenge both O-2(center dot-) and NO center dot (29.62 and 52.48g/mL, respectively). It also showed a good AO activity in the polarographic HPMC assay (950%/mL). p-Hydroxybenzoic acid may be one of the responsible compounds for the afore-mentioned activities. The same extract also exhibited a concentration-dependent cytotoxicity against MCF-7 and HepG2 tumour cell lines reaching IC50 values of 123.51 and 134.29g/mL, respectively with no cytotoxic activity against normal MRC-5 cells. Gentisic, syringic and protocatechuic acids may be among the bioactive principles for the observed cytotoxicity. Taken all together, T. versicolor ethanol extract can be considered as a promising candidate for development of health promoting food supplement. [GRAPHICS] .
Keywords:
Trametes versicolor / ethanol extract / antiradical activity / antioxidant activity / cytotoxic activity / hydroxybenzoic acidsSource:
Natural Product Research, 2018, 32, 8, 963-967Publisher:
- Taylor & Francis Ltd, Abingdon
Funding / projects:
- Natural products of wild, cultivated and edible plants: structure and bioactivity determination (RS-MESTD-Basic Research (BR or ON)-172053)
- Bioactive natural products as potential sources of new pharmaceuticals and food supplements (RS-MESTD-Basic Research (BR or ON)-172058)
Note:
- Supplementary material: http://cherry.chem.bg.ac.rs/handle/123456789/2896
DOI: 10.1080/14786419.2017.1366484
ISSN: 1478-6419
PubMed: 28817965
WoS: 000423771400015
Scopus: 2-s2.0-85027868180
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Institution/Community
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Janjušević, Ljiljana AU - Pejin, Boris AU - Kaišarević, Sonja AU - Gorjanović, Stanislava AU - Pastor, Ferenc AU - Tešanović, Kristina AU - Karaman, Maja PY - 2018 UR - https://cherry.chem.bg.ac.rs/handle/123456789/2076 AB - This study aimed to estimate antiradical, antioxidant (AO) and cytotoxic activities of the fungus Trametes versicolor ethanol fruiting body extract. The extract was found to effectively scavenge both O-2(center dot-) and NO center dot (29.62 and 52.48g/mL, respectively). It also showed a good AO activity in the polarographic HPMC assay (950%/mL). p-Hydroxybenzoic acid may be one of the responsible compounds for the afore-mentioned activities. The same extract also exhibited a concentration-dependent cytotoxicity against MCF-7 and HepG2 tumour cell lines reaching IC50 values of 123.51 and 134.29g/mL, respectively with no cytotoxic activity against normal MRC-5 cells. Gentisic, syringic and protocatechuic acids may be among the bioactive principles for the observed cytotoxicity. Taken all together, T. versicolor ethanol extract can be considered as a promising candidate for development of health promoting food supplement. [GRAPHICS] . PB - Taylor & Francis Ltd, Abingdon T2 - Natural Product Research T1 - Trametes versicolor ethanol extract, a promising candidate for health-promoting food supplement VL - 32 IS - 8 SP - 963 EP - 967 DO - 10.1080/14786419.2017.1366484 ER -
@article{ author = "Janjušević, Ljiljana and Pejin, Boris and Kaišarević, Sonja and Gorjanović, Stanislava and Pastor, Ferenc and Tešanović, Kristina and Karaman, Maja", year = "2018", abstract = "This study aimed to estimate antiradical, antioxidant (AO) and cytotoxic activities of the fungus Trametes versicolor ethanol fruiting body extract. The extract was found to effectively scavenge both O-2(center dot-) and NO center dot (29.62 and 52.48g/mL, respectively). It also showed a good AO activity in the polarographic HPMC assay (950%/mL). p-Hydroxybenzoic acid may be one of the responsible compounds for the afore-mentioned activities. The same extract also exhibited a concentration-dependent cytotoxicity against MCF-7 and HepG2 tumour cell lines reaching IC50 values of 123.51 and 134.29g/mL, respectively with no cytotoxic activity against normal MRC-5 cells. Gentisic, syringic and protocatechuic acids may be among the bioactive principles for the observed cytotoxicity. Taken all together, T. versicolor ethanol extract can be considered as a promising candidate for development of health promoting food supplement. [GRAPHICS] .", publisher = "Taylor & Francis Ltd, Abingdon", journal = "Natural Product Research", title = "Trametes versicolor ethanol extract, a promising candidate for health-promoting food supplement", volume = "32", number = "8", pages = "963-967", doi = "10.1080/14786419.2017.1366484" }
Janjušević, L., Pejin, B., Kaišarević, S., Gorjanović, S., Pastor, F., Tešanović, K.,& Karaman, M.. (2018). Trametes versicolor ethanol extract, a promising candidate for health-promoting food supplement. in Natural Product Research Taylor & Francis Ltd, Abingdon., 32(8), 963-967. https://doi.org/10.1080/14786419.2017.1366484
Janjušević L, Pejin B, Kaišarević S, Gorjanović S, Pastor F, Tešanović K, Karaman M. Trametes versicolor ethanol extract, a promising candidate for health-promoting food supplement. in Natural Product Research. 2018;32(8):963-967. doi:10.1080/14786419.2017.1366484 .
Janjušević, Ljiljana, Pejin, Boris, Kaišarević, Sonja, Gorjanović, Stanislava, Pastor, Ferenc, Tešanović, Kristina, Karaman, Maja, "Trametes versicolor ethanol extract, a promising candidate for health-promoting food supplement" in Natural Product Research, 32, no. 8 (2018):963-967, https://doi.org/10.1080/14786419.2017.1366484 . .