Strain differences of cadmium-induced toxicity in rats: Insight from spleen and lung immune responses
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2016
Authors
Demenesku, JelenaPopov-Aleksandrov, Aleksandra
Mirkov, Ivana
Ninkov, Marina
Zolotarevski, Lidija
Kataranovski, Dragan
Brčeski, Ilija
Kataranovski, Milena
Article (Published version)
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The impact of genetic background on effects of acute i.p. cadmium administration (0.5 mg/kg and 1 mg/kg) on basic immune activity of spleen and lungs was examined in two rat strains, Albino Oxford (AO) and Dark Agouti (DA), known to react differently to chemicals. More pronounced inhibition of Concanavalin A (ConA)-induced and Interleukin (IL)-2 stimulated spleen cell proliferation as well as higher levels of nitric oxide (known to decrease cell's proliferative ability) in DA rats at 1 mg/kg, along with greater inhibition of ConA-induced Interferon (IFN-gamma)-production by total and mononuclear (MNC) spleen cells and IL-17 production by spleen MNC in DA vs. AO rats at this dose show greater susceptibility of this strain to Cd effects on spleen cells response. More pronounced infiltration of neutrophils/CD11b(+) cells to lungs of DA rats treated with 1 mg/kg of Cd and decreased IL-17 lung cell responses noted solely in DA rats speaks in favor of their higher susceptibility to this meta...l. However, lack of strain disparity in lung cells IFN-gamma responses show that there are regional differences as well. Novel data from this study depict complexity of the influence of genetic background on the effects of cadmium on host immune reactivity. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
Keywords:
Cadmium / Rats / Albino Oxford (AO) and Dark Agouti (DA) / strains / Spleen / LungsSource:
Toxicology Letters, 2016, 256, 33-43Publisher:
- Elsevier Ireland Ltd, Clare
Funding / projects:
- Immunomodulatory effects of environmental xenobiotics and biotic factors on the populations of mouse-like rodents (RS-MESTD-Basic Research (BR or ON)-173039)
Note:
- Peer-reviewed manuscript: http://cherry.chem.bg.ac.rs/handle/123456789/3615
DOI: 10.1016/j.toxlet.2016.05.022
ISSN: 0378-4274
PubMed: 27234498
WoS: 000378049900004
Scopus: 2-s2.0-84971473046
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Institution/Community
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Demenesku, Jelena AU - Popov-Aleksandrov, Aleksandra AU - Mirkov, Ivana AU - Ninkov, Marina AU - Zolotarevski, Lidija AU - Kataranovski, Dragan AU - Brčeski, Ilija AU - Kataranovski, Milena PY - 2016 UR - https://cherry.chem.bg.ac.rs/handle/123456789/2266 AB - The impact of genetic background on effects of acute i.p. cadmium administration (0.5 mg/kg and 1 mg/kg) on basic immune activity of spleen and lungs was examined in two rat strains, Albino Oxford (AO) and Dark Agouti (DA), known to react differently to chemicals. More pronounced inhibition of Concanavalin A (ConA)-induced and Interleukin (IL)-2 stimulated spleen cell proliferation as well as higher levels of nitric oxide (known to decrease cell's proliferative ability) in DA rats at 1 mg/kg, along with greater inhibition of ConA-induced Interferon (IFN-gamma)-production by total and mononuclear (MNC) spleen cells and IL-17 production by spleen MNC in DA vs. AO rats at this dose show greater susceptibility of this strain to Cd effects on spleen cells response. More pronounced infiltration of neutrophils/CD11b(+) cells to lungs of DA rats treated with 1 mg/kg of Cd and decreased IL-17 lung cell responses noted solely in DA rats speaks in favor of their higher susceptibility to this metal. However, lack of strain disparity in lung cells IFN-gamma responses show that there are regional differences as well. Novel data from this study depict complexity of the influence of genetic background on the effects of cadmium on host immune reactivity. (C) 2016 Elsevier Ireland Ltd. All rights reserved. PB - Elsevier Ireland Ltd, Clare T2 - Toxicology Letters T1 - Strain differences of cadmium-induced toxicity in rats: Insight from spleen and lung immune responses VL - 256 SP - 33 EP - 43 DO - 10.1016/j.toxlet.2016.05.022 ER -
@article{ author = "Demenesku, Jelena and Popov-Aleksandrov, Aleksandra and Mirkov, Ivana and Ninkov, Marina and Zolotarevski, Lidija and Kataranovski, Dragan and Brčeski, Ilija and Kataranovski, Milena", year = "2016", abstract = "The impact of genetic background on effects of acute i.p. cadmium administration (0.5 mg/kg and 1 mg/kg) on basic immune activity of spleen and lungs was examined in two rat strains, Albino Oxford (AO) and Dark Agouti (DA), known to react differently to chemicals. More pronounced inhibition of Concanavalin A (ConA)-induced and Interleukin (IL)-2 stimulated spleen cell proliferation as well as higher levels of nitric oxide (known to decrease cell's proliferative ability) in DA rats at 1 mg/kg, along with greater inhibition of ConA-induced Interferon (IFN-gamma)-production by total and mononuclear (MNC) spleen cells and IL-17 production by spleen MNC in DA vs. AO rats at this dose show greater susceptibility of this strain to Cd effects on spleen cells response. More pronounced infiltration of neutrophils/CD11b(+) cells to lungs of DA rats treated with 1 mg/kg of Cd and decreased IL-17 lung cell responses noted solely in DA rats speaks in favor of their higher susceptibility to this metal. However, lack of strain disparity in lung cells IFN-gamma responses show that there are regional differences as well. Novel data from this study depict complexity of the influence of genetic background on the effects of cadmium on host immune reactivity. (C) 2016 Elsevier Ireland Ltd. All rights reserved.", publisher = "Elsevier Ireland Ltd, Clare", journal = "Toxicology Letters", title = "Strain differences of cadmium-induced toxicity in rats: Insight from spleen and lung immune responses", volume = "256", pages = "33-43", doi = "10.1016/j.toxlet.2016.05.022" }
Demenesku, J., Popov-Aleksandrov, A., Mirkov, I., Ninkov, M., Zolotarevski, L., Kataranovski, D., Brčeski, I.,& Kataranovski, M.. (2016). Strain differences of cadmium-induced toxicity in rats: Insight from spleen and lung immune responses. in Toxicology Letters Elsevier Ireland Ltd, Clare., 256, 33-43. https://doi.org/10.1016/j.toxlet.2016.05.022
Demenesku J, Popov-Aleksandrov A, Mirkov I, Ninkov M, Zolotarevski L, Kataranovski D, Brčeski I, Kataranovski M. Strain differences of cadmium-induced toxicity in rats: Insight from spleen and lung immune responses. in Toxicology Letters. 2016;256:33-43. doi:10.1016/j.toxlet.2016.05.022 .
Demenesku, Jelena, Popov-Aleksandrov, Aleksandra, Mirkov, Ivana, Ninkov, Marina, Zolotarevski, Lidija, Kataranovski, Dragan, Brčeski, Ilija, Kataranovski, Milena, "Strain differences of cadmium-induced toxicity in rats: Insight from spleen and lung immune responses" in Toxicology Letters, 256 (2016):33-43, https://doi.org/10.1016/j.toxlet.2016.05.022 . .