Non-immediate hypersensitivity reactions to beta-lactam antibiotics in children - our 10-year experience in allergy work-up
Само за регистроване кориснике
2016
Аутори
Atanasković-Marković, MarinaGaeta, Francesco
Međo, Biljana
Gavrović-Jankulović, Marija
Ćirković-Veličković, Tanja
Tmušić, Vladimir
Romano, Antonino
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
BackgroundNon-immediate reactions to beta-lactam antibiotics (BL) occur more than one hour after drug administration, and the most common manifestations are maculopapular exanthemas and delayed-appearing urticaria and/or angioedema. Infections can lead to skin eruptions and mimic drug hypersensitivity reactions (DHR), if a drug is taken at the same time. The most of children are labeled as drug allergic' after considering only the clinical history. ObjectiveTo diagnose/detect a hypersensitivity or an infection which mimic DHR in children with non-immediate reactions to BL MethodsA prospective survey was conducted in a group of 1026 children with histories of non-immediate reactions to BL by performing patch tests, skin tests, and in case of negative results, drug provocation tests (DPTs). In 300 children, a study was performed to detect infections by viruses or Mycoplasma pneumoniae. ResultsUrticaria and maculopapular exanthemas were the most reported non-immediate reactions. Only 76 (...7.4%) of 1026 children had confirmed non-immediate hypersensitivity reactions to BL. Fifty-seven children had positive delayed-reading intradermal tests (18 of these with a positive patch test). Nineteen children had positive DPT. Sixty-six of 300 children had positive tests for viruses or Mycoplasma pneumoniae and 2 of them had a positive allergy work-up. ConclusionsA diagnostic work-up should be performed in all children with non-immediate reactions to BL, to remove a false label of hypersensitivity. Even though only 57 (5.5%) of 1026 children displayed positive responses to delayed-reading intradermal tests to BL, such tests appear to be useful in order to reduce the risk for positive DPTs.
Кључне речи:
allergy work-up / beta-lactams / children / non-immediate hypersensitivity reactions / provocation test / skin testИзвор:
Pediatric Allergy and Immunology, 2016, 27, 5, 533-538Издавач:
- Wiley, Hoboken
Финансирање / пројекти:
- Молекуларне особине и модификације неких респираторних и нутритивних алергена (RS-MESTD-Basic Research (BR or ON)-172024)
- Алергени, антитела, ензими и мали физиолошки значајни молекули: дизајн, структура, функција и значај (RS-MESTD-Basic Research (BR or ON)-172049)
DOI: 10.1111/pai.12565
ISSN: 0905-6157
PubMed: 26999792
WoS: 000379928100014
Scopus: 2-s2.0-84978264083
Колекције
Институција/група
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Atanasković-Marković, Marina AU - Gaeta, Francesco AU - Međo, Biljana AU - Gavrović-Jankulović, Marija AU - Ćirković-Veličković, Tanja AU - Tmušić, Vladimir AU - Romano, Antonino PY - 2016 UR - https://cherry.chem.bg.ac.rs/handle/123456789/2278 AB - BackgroundNon-immediate reactions to beta-lactam antibiotics (BL) occur more than one hour after drug administration, and the most common manifestations are maculopapular exanthemas and delayed-appearing urticaria and/or angioedema. Infections can lead to skin eruptions and mimic drug hypersensitivity reactions (DHR), if a drug is taken at the same time. The most of children are labeled as drug allergic' after considering only the clinical history. ObjectiveTo diagnose/detect a hypersensitivity or an infection which mimic DHR in children with non-immediate reactions to BL MethodsA prospective survey was conducted in a group of 1026 children with histories of non-immediate reactions to BL by performing patch tests, skin tests, and in case of negative results, drug provocation tests (DPTs). In 300 children, a study was performed to detect infections by viruses or Mycoplasma pneumoniae. ResultsUrticaria and maculopapular exanthemas were the most reported non-immediate reactions. Only 76 (7.4%) of 1026 children had confirmed non-immediate hypersensitivity reactions to BL. Fifty-seven children had positive delayed-reading intradermal tests (18 of these with a positive patch test). Nineteen children had positive DPT. Sixty-six of 300 children had positive tests for viruses or Mycoplasma pneumoniae and 2 of them had a positive allergy work-up. ConclusionsA diagnostic work-up should be performed in all children with non-immediate reactions to BL, to remove a false label of hypersensitivity. Even though only 57 (5.5%) of 1026 children displayed positive responses to delayed-reading intradermal tests to BL, such tests appear to be useful in order to reduce the risk for positive DPTs. PB - Wiley, Hoboken T2 - Pediatric Allergy and Immunology T1 - Non-immediate hypersensitivity reactions to beta-lactam antibiotics in children - our 10-year experience in allergy work-up VL - 27 IS - 5 SP - 533 EP - 538 DO - 10.1111/pai.12565 ER -
@article{ author = "Atanasković-Marković, Marina and Gaeta, Francesco and Međo, Biljana and Gavrović-Jankulović, Marija and Ćirković-Veličković, Tanja and Tmušić, Vladimir and Romano, Antonino", year = "2016", abstract = "BackgroundNon-immediate reactions to beta-lactam antibiotics (BL) occur more than one hour after drug administration, and the most common manifestations are maculopapular exanthemas and delayed-appearing urticaria and/or angioedema. Infections can lead to skin eruptions and mimic drug hypersensitivity reactions (DHR), if a drug is taken at the same time. The most of children are labeled as drug allergic' after considering only the clinical history. ObjectiveTo diagnose/detect a hypersensitivity or an infection which mimic DHR in children with non-immediate reactions to BL MethodsA prospective survey was conducted in a group of 1026 children with histories of non-immediate reactions to BL by performing patch tests, skin tests, and in case of negative results, drug provocation tests (DPTs). In 300 children, a study was performed to detect infections by viruses or Mycoplasma pneumoniae. ResultsUrticaria and maculopapular exanthemas were the most reported non-immediate reactions. Only 76 (7.4%) of 1026 children had confirmed non-immediate hypersensitivity reactions to BL. Fifty-seven children had positive delayed-reading intradermal tests (18 of these with a positive patch test). Nineteen children had positive DPT. Sixty-six of 300 children had positive tests for viruses or Mycoplasma pneumoniae and 2 of them had a positive allergy work-up. ConclusionsA diagnostic work-up should be performed in all children with non-immediate reactions to BL, to remove a false label of hypersensitivity. Even though only 57 (5.5%) of 1026 children displayed positive responses to delayed-reading intradermal tests to BL, such tests appear to be useful in order to reduce the risk for positive DPTs.", publisher = "Wiley, Hoboken", journal = "Pediatric Allergy and Immunology", title = "Non-immediate hypersensitivity reactions to beta-lactam antibiotics in children - our 10-year experience in allergy work-up", volume = "27", number = "5", pages = "533-538", doi = "10.1111/pai.12565" }
Atanasković-Marković, M., Gaeta, F., Međo, B., Gavrović-Jankulović, M., Ćirković-Veličković, T., Tmušić, V.,& Romano, A.. (2016). Non-immediate hypersensitivity reactions to beta-lactam antibiotics in children - our 10-year experience in allergy work-up. in Pediatric Allergy and Immunology Wiley, Hoboken., 27(5), 533-538. https://doi.org/10.1111/pai.12565
Atanasković-Marković M, Gaeta F, Međo B, Gavrović-Jankulović M, Ćirković-Veličković T, Tmušić V, Romano A. Non-immediate hypersensitivity reactions to beta-lactam antibiotics in children - our 10-year experience in allergy work-up. in Pediatric Allergy and Immunology. 2016;27(5):533-538. doi:10.1111/pai.12565 .
Atanasković-Marković, Marina, Gaeta, Francesco, Međo, Biljana, Gavrović-Jankulović, Marija, Ćirković-Veličković, Tanja, Tmušić, Vladimir, Romano, Antonino, "Non-immediate hypersensitivity reactions to beta-lactam antibiotics in children - our 10-year experience in allergy work-up" in Pediatric Allergy and Immunology, 27, no. 5 (2016):533-538, https://doi.org/10.1111/pai.12565 . .