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Non-immediate hypersensitivity reactions to beta-lactam antibiotics in children - our 10-year experience in allergy work-up
dc.creator | Atanasković-Marković, Marina | |
dc.creator | Gaeta, Francesco | |
dc.creator | Međo, Biljana | |
dc.creator | Gavrović-Jankulović, Marija | |
dc.creator | Ćirković-Veličković, Tanja | |
dc.creator | Tmušić, Vladimir | |
dc.creator | Romano, Antonino | |
dc.date.accessioned | 2018-11-22T00:36:16Z | |
dc.date.available | 2018-11-22T00:36:16Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 0905-6157 | |
dc.identifier.uri | https://cherry.chem.bg.ac.rs/handle/123456789/2278 | |
dc.description.abstract | BackgroundNon-immediate reactions to beta-lactam antibiotics (BL) occur more than one hour after drug administration, and the most common manifestations are maculopapular exanthemas and delayed-appearing urticaria and/or angioedema. Infections can lead to skin eruptions and mimic drug hypersensitivity reactions (DHR), if a drug is taken at the same time. The most of children are labeled as drug allergic' after considering only the clinical history. ObjectiveTo diagnose/detect a hypersensitivity or an infection which mimic DHR in children with non-immediate reactions to BL MethodsA prospective survey was conducted in a group of 1026 children with histories of non-immediate reactions to BL by performing patch tests, skin tests, and in case of negative results, drug provocation tests (DPTs). In 300 children, a study was performed to detect infections by viruses or Mycoplasma pneumoniae. ResultsUrticaria and maculopapular exanthemas were the most reported non-immediate reactions. Only 76 (7.4%) of 1026 children had confirmed non-immediate hypersensitivity reactions to BL. Fifty-seven children had positive delayed-reading intradermal tests (18 of these with a positive patch test). Nineteen children had positive DPT. Sixty-six of 300 children had positive tests for viruses or Mycoplasma pneumoniae and 2 of them had a positive allergy work-up. ConclusionsA diagnostic work-up should be performed in all children with non-immediate reactions to BL, to remove a false label of hypersensitivity. Even though only 57 (5.5%) of 1026 children displayed positive responses to delayed-reading intradermal tests to BL, such tests appear to be useful in order to reduce the risk for positive DPTs. | en |
dc.publisher | Wiley, Hoboken | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172024/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172049/RS// | |
dc.rights | restrictedAccess | |
dc.source | Pediatric Allergy and Immunology | |
dc.subject | allergy work-up | en |
dc.subject | beta-lactams | en |
dc.subject | children | en |
dc.subject | non-immediate hypersensitivity reactions | en |
dc.subject | provocation test | en |
dc.subject | skin test | en |
dc.title | Non-immediate hypersensitivity reactions to beta-lactam antibiotics in children - our 10-year experience in allergy work-up | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Ћирковић-Величковић, Тања; Aтанасковиц-Марковиц, Марина; Гавровић-Јанкуловић, Марија; Тмусиц, Владимир; Медјо, Биљана; Гаета, Францесцо; Романо, Aнтонино; | |
dc.citation.volume | 27 | |
dc.citation.issue | 5 | |
dc.citation.spage | 533 | |
dc.citation.epage | 538 | |
dc.identifier.wos | 000379928100014 | |
dc.identifier.doi | 10.1111/pai.12565 | |
dc.citation.other | 27(5): 533-538 | |
dc.citation.rank | M21 | |
dc.identifier.pmid | 26999792 | |
dc.type.version | publishedVersion | en |
dc.identifier.scopus | 2-s2.0-84978264083 |