Strain differences in toxicity of oral cadmium intake in rats
Само за регистроване кориснике
2016
Аутори
Ninkov, MarinaPopov-Aleksandrov, Aleksandra
Mirkov, Ivana
Demenesku, Jelena
Mileusnić, Dina
Jovanović-Stojanov, Sofija
Golić, Nataša
Tolinački, Maja
Zolotarevski, Lidija
Kataranovski, Dragan
Brčeski, Ilija
Kataranovski, Milena
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Influence of genetic background on toxicity of oral cadmium (Cd) administration (30 days, in drinking water; 5 ppm and 50 ppm of cadmium) was examined in Albino Oxford (AO) and Dark Agouti (DA) rats. Similar cadmium deposition was noted in gut and draining mesenteric lymph nodes (MLN) of both strains but intensity and/or the pattern of responses to cadmium in these tissues differ. Less intense intestinal damage and leukocyte infiltration was observed in gut of cadmium-exposed AO rats. While gut-associated lymph node cells of DA rats responded to cadmium with an increase of cell proliferation, oxidative activity, IFN-gamma, IL-17 production and expression, no changes of these activities of MLN cells of cadmium-treated AO rats were observed. Spleen, which accumulated cadmium comparable to MLN, responded to metal by drop in cell viability and by reduced responsiveness of proliferation and cytokine production to stimulation in DA rats solely, which suggest tissue dependence of cadmium effe...cts. More pronounced cadmium effects on MLN and spleen cells of DA rats (which accumulated similar cadmium doses as AO rats), showed greater susceptibility of this strain to cadmium. The results presented, for the first time, depict the influence of genetic background to effects of oral cadmium administration. (C) 2016 Elsevier Ltd. All rights reserved.
Кључне речи:
Oral cadmium administration / AO and DA rats / Intestine / Mesenteric lymph nodes / SpleenИзвор:
Food and Chemical Toxicology, 2016, 96, 11-23Издавач:
- Pergamon-Elsevier Science Ltd, Oxford
Финансирање / пројекти:
- Имуномодулаторни ефекти ксенобиотика и биотичких фактора животне средине на популације мишоликих глодара (RS-MESTD-Basic Research (BR or ON)-173039)
DOI: 10.1016/j.fct.2016.07.021
ISSN: 0278-6915
PubMed: 27451944
WoS: 000383825300002
Scopus: 2-s2.0-84979701170
Колекције
Институција/група
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Ninkov, Marina AU - Popov-Aleksandrov, Aleksandra AU - Mirkov, Ivana AU - Demenesku, Jelena AU - Mileusnić, Dina AU - Jovanović-Stojanov, Sofija AU - Golić, Nataša AU - Tolinački, Maja AU - Zolotarevski, Lidija AU - Kataranovski, Dragan AU - Brčeski, Ilija AU - Kataranovski, Milena PY - 2016 UR - https://cherry.chem.bg.ac.rs/handle/123456789/2312 AB - Influence of genetic background on toxicity of oral cadmium (Cd) administration (30 days, in drinking water; 5 ppm and 50 ppm of cadmium) was examined in Albino Oxford (AO) and Dark Agouti (DA) rats. Similar cadmium deposition was noted in gut and draining mesenteric lymph nodes (MLN) of both strains but intensity and/or the pattern of responses to cadmium in these tissues differ. Less intense intestinal damage and leukocyte infiltration was observed in gut of cadmium-exposed AO rats. While gut-associated lymph node cells of DA rats responded to cadmium with an increase of cell proliferation, oxidative activity, IFN-gamma, IL-17 production and expression, no changes of these activities of MLN cells of cadmium-treated AO rats were observed. Spleen, which accumulated cadmium comparable to MLN, responded to metal by drop in cell viability and by reduced responsiveness of proliferation and cytokine production to stimulation in DA rats solely, which suggest tissue dependence of cadmium effects. More pronounced cadmium effects on MLN and spleen cells of DA rats (which accumulated similar cadmium doses as AO rats), showed greater susceptibility of this strain to cadmium. The results presented, for the first time, depict the influence of genetic background to effects of oral cadmium administration. (C) 2016 Elsevier Ltd. All rights reserved. PB - Pergamon-Elsevier Science Ltd, Oxford T2 - Food and Chemical Toxicology T1 - Strain differences in toxicity of oral cadmium intake in rats VL - 96 SP - 11 EP - 23 DO - 10.1016/j.fct.2016.07.021 ER -
@article{ author = "Ninkov, Marina and Popov-Aleksandrov, Aleksandra and Mirkov, Ivana and Demenesku, Jelena and Mileusnić, Dina and Jovanović-Stojanov, Sofija and Golić, Nataša and Tolinački, Maja and Zolotarevski, Lidija and Kataranovski, Dragan and Brčeski, Ilija and Kataranovski, Milena", year = "2016", abstract = "Influence of genetic background on toxicity of oral cadmium (Cd) administration (30 days, in drinking water; 5 ppm and 50 ppm of cadmium) was examined in Albino Oxford (AO) and Dark Agouti (DA) rats. Similar cadmium deposition was noted in gut and draining mesenteric lymph nodes (MLN) of both strains but intensity and/or the pattern of responses to cadmium in these tissues differ. Less intense intestinal damage and leukocyte infiltration was observed in gut of cadmium-exposed AO rats. While gut-associated lymph node cells of DA rats responded to cadmium with an increase of cell proliferation, oxidative activity, IFN-gamma, IL-17 production and expression, no changes of these activities of MLN cells of cadmium-treated AO rats were observed. Spleen, which accumulated cadmium comparable to MLN, responded to metal by drop in cell viability and by reduced responsiveness of proliferation and cytokine production to stimulation in DA rats solely, which suggest tissue dependence of cadmium effects. More pronounced cadmium effects on MLN and spleen cells of DA rats (which accumulated similar cadmium doses as AO rats), showed greater susceptibility of this strain to cadmium. The results presented, for the first time, depict the influence of genetic background to effects of oral cadmium administration. (C) 2016 Elsevier Ltd. All rights reserved.", publisher = "Pergamon-Elsevier Science Ltd, Oxford", journal = "Food and Chemical Toxicology", title = "Strain differences in toxicity of oral cadmium intake in rats", volume = "96", pages = "11-23", doi = "10.1016/j.fct.2016.07.021" }
Ninkov, M., Popov-Aleksandrov, A., Mirkov, I., Demenesku, J., Mileusnić, D., Jovanović-Stojanov, S., Golić, N., Tolinački, M., Zolotarevski, L., Kataranovski, D., Brčeski, I.,& Kataranovski, M.. (2016). Strain differences in toxicity of oral cadmium intake in rats. in Food and Chemical Toxicology Pergamon-Elsevier Science Ltd, Oxford., 96, 11-23. https://doi.org/10.1016/j.fct.2016.07.021
Ninkov M, Popov-Aleksandrov A, Mirkov I, Demenesku J, Mileusnić D, Jovanović-Stojanov S, Golić N, Tolinački M, Zolotarevski L, Kataranovski D, Brčeski I, Kataranovski M. Strain differences in toxicity of oral cadmium intake in rats. in Food and Chemical Toxicology. 2016;96:11-23. doi:10.1016/j.fct.2016.07.021 .
Ninkov, Marina, Popov-Aleksandrov, Aleksandra, Mirkov, Ivana, Demenesku, Jelena, Mileusnić, Dina, Jovanović-Stojanov, Sofija, Golić, Nataša, Tolinački, Maja, Zolotarevski, Lidija, Kataranovski, Dragan, Brčeski, Ilija, Kataranovski, Milena, "Strain differences in toxicity of oral cadmium intake in rats" in Food and Chemical Toxicology, 96 (2016):11-23, https://doi.org/10.1016/j.fct.2016.07.021 . .