Novel Strategy for Electroanalytical Detection of Antipsychotic Drugs Chlorpromazine and Thioridazine; Possibilities for Simultaneous Determination
Апстракт
A simple and fast method for determination of two phenothiazine drugs, chlorpromazine (CPZ) and thioridazine (TDZ), at the boron-doped diamond electrode (BDDE) was proposed. Oxidation peaks on potentials higher than 1 V were used for quantitation of investigated phenothiazines due to better selectivity over common interfering compounds in urine. Differential pulse voltammetry was applied for trace determination of CPZ and TDZ, in Britton-Robinson buffer solution at optimal pH. Under optimized DPV conditions a linear analytical curve was obtained from 1.0x10(-7) to 4.0x10(-5) M with a detection limit of 0.3x10(-7) M (for CPZ) and in the concentration range of 2x10(-7) M to 4.0x10(-5) M, with a detection limit of 1.2x10(-7)M (for TDZ). The applicability of the method was proved by determination of CPZ and TDZ by proposed procedures in spiked urine samples. The electrochemical behavior of those two important tranquilizers in different solvents was described, exploring the possibility of s...imultaneous determination.
Кључне речи:
voltammetric method / chlorpromazine / thioridazine / boron-doped diamond electrode / human urineИзвор:
International Journal of Electrochemical Science, 2017, 12, 5, 3709-3720Издавач:
- Esg, Belgrade
Финансирање / пројекти:
- Вишескално структурирање полимерних нанокомпозита и функционалних материјала применом различитих прекурсора (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-45022)
- Примена унапређених оксидационих процеса и наноструктурисаних оксидних материјала за уклањање загађивача из животне средине, развој и оптимизација инструменталних техника за праћење ефикасности (RS-MESTD-Basic Research (BR or ON)-172030)
- Strengthening of the MagBioVin Research and Innovation Team for Development of Novel Approaches for Tumour Therapy based on Nanostructured Materials (EU-FP7-621375)
DOI: 10.20964/2017.05.34
ISSN: 1452-3981
WoS: 000402485100013
Scopus: 2-s2.0-85019613952
Институција/група
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Petković, Branka B. AU - Kuzmanović, Darko AU - Dimitrijević, Teodora AU - Krstic, M. P. AU - Stanković, Dalibor PY - 2017 UR - https://cherry.chem.bg.ac.rs/handle/123456789/2465 AB - A simple and fast method for determination of two phenothiazine drugs, chlorpromazine (CPZ) and thioridazine (TDZ), at the boron-doped diamond electrode (BDDE) was proposed. Oxidation peaks on potentials higher than 1 V were used for quantitation of investigated phenothiazines due to better selectivity over common interfering compounds in urine. Differential pulse voltammetry was applied for trace determination of CPZ and TDZ, in Britton-Robinson buffer solution at optimal pH. Under optimized DPV conditions a linear analytical curve was obtained from 1.0x10(-7) to 4.0x10(-5) M with a detection limit of 0.3x10(-7) M (for CPZ) and in the concentration range of 2x10(-7) M to 4.0x10(-5) M, with a detection limit of 1.2x10(-7)M (for TDZ). The applicability of the method was proved by determination of CPZ and TDZ by proposed procedures in spiked urine samples. The electrochemical behavior of those two important tranquilizers in different solvents was described, exploring the possibility of simultaneous determination. PB - Esg, Belgrade T2 - International Journal of Electrochemical Science T1 - Novel Strategy for Electroanalytical Detection of Antipsychotic Drugs Chlorpromazine and Thioridazine; Possibilities for Simultaneous Determination VL - 12 IS - 5 SP - 3709 EP - 3720 DO - 10.20964/2017.05.34 ER -
@article{ author = "Petković, Branka B. and Kuzmanović, Darko and Dimitrijević, Teodora and Krstic, M. P. and Stanković, Dalibor", year = "2017", abstract = "A simple and fast method for determination of two phenothiazine drugs, chlorpromazine (CPZ) and thioridazine (TDZ), at the boron-doped diamond electrode (BDDE) was proposed. Oxidation peaks on potentials higher than 1 V were used for quantitation of investigated phenothiazines due to better selectivity over common interfering compounds in urine. Differential pulse voltammetry was applied for trace determination of CPZ and TDZ, in Britton-Robinson buffer solution at optimal pH. Under optimized DPV conditions a linear analytical curve was obtained from 1.0x10(-7) to 4.0x10(-5) M with a detection limit of 0.3x10(-7) M (for CPZ) and in the concentration range of 2x10(-7) M to 4.0x10(-5) M, with a detection limit of 1.2x10(-7)M (for TDZ). The applicability of the method was proved by determination of CPZ and TDZ by proposed procedures in spiked urine samples. The electrochemical behavior of those two important tranquilizers in different solvents was described, exploring the possibility of simultaneous determination.", publisher = "Esg, Belgrade", journal = "International Journal of Electrochemical Science", title = "Novel Strategy for Electroanalytical Detection of Antipsychotic Drugs Chlorpromazine and Thioridazine; Possibilities for Simultaneous Determination", volume = "12", number = "5", pages = "3709-3720", doi = "10.20964/2017.05.34" }
Petković, B. B., Kuzmanović, D., Dimitrijević, T., Krstic, M. P.,& Stanković, D.. (2017). Novel Strategy for Electroanalytical Detection of Antipsychotic Drugs Chlorpromazine and Thioridazine; Possibilities for Simultaneous Determination. in International Journal of Electrochemical Science Esg, Belgrade., 12(5), 3709-3720. https://doi.org/10.20964/2017.05.34
Petković BB, Kuzmanović D, Dimitrijević T, Krstic MP, Stanković D. Novel Strategy for Electroanalytical Detection of Antipsychotic Drugs Chlorpromazine and Thioridazine; Possibilities for Simultaneous Determination. in International Journal of Electrochemical Science. 2017;12(5):3709-3720. doi:10.20964/2017.05.34 .
Petković, Branka B., Kuzmanović, Darko, Dimitrijević, Teodora, Krstic, M. P., Stanković, Dalibor, "Novel Strategy for Electroanalytical Detection of Antipsychotic Drugs Chlorpromazine and Thioridazine; Possibilities for Simultaneous Determination" in International Journal of Electrochemical Science, 12, no. 5 (2017):3709-3720, https://doi.org/10.20964/2017.05.34 . .