Bioactive Pentacyclic Triterpene Ester Derivatives from Alnus viridis ssp viridis Bark
Samo za registrovane korisnike
2017
Autori
Novaković, Miroslav M.Nikodinović-Runić, Jasmina
Veselinović, Jovana
Ilić-Tomić, Tatjana
Vidaković, Vera
Tešević, Vele
Milosavljević, Slobodan M.
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Seven derivatives of pentacyclic triterpene acids (1-7) were isolated from the bark of Alnus viridis ssp. viridis using a combination of column chromatography and semipreparative HPLC. Compounds 1-3, 6, and 7 were determined to be new after spectroscopic data interpretation and were assigned as 27-hydroxyalphitolic acid derivatives (1-3), a 27-hydroxybetulinic acid derivative (6), and a 3-epi-maslinic acid derivative (7), respectively. Pentacyclic triterpenoids with a C-27 hydroxymethyl group have been found in species of the genus Alnus for the first time. These compounds were subjected to cytotoxicity testing against a number of canter cell lines. Also, selected pentacyclic triterpenoids were selected as potential inhibitors of topoisomerases I and Ha for an in silico investigation.
Izvor:
Journal of Natural Products, 2017, 80, 5, 1255-1263Izdavač:
- Amer Chemical Soc, Washington
Finansiranje / projekti:
- Bioaktivni prirodni proizvodi samoniklih, gajenih i jestivih biljaka: određivanje struktura i aktivnosti (RS-MESTD-Basic Research (BR or ON)-172053)
- Izučavanje mikrobiološkog diverziteta i karakterizacija korisnih sredinskih mikroorganizama (RS-MESTD-Basic Research (BR or ON)-173048)
Napomena:
- Supplementary material: http://cherry.chem.bg.ac.rs/handle/123456789/3088
DOI: 10.1021/acs.jnatprod.6b00805
ISSN: 0163-3864
PubMed: 28368586
WoS: 000402498300004
Scopus: 2-s2.0-85019767389
Institucija/grupa
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Novaković, Miroslav M. AU - Nikodinović-Runić, Jasmina AU - Veselinović, Jovana AU - Ilić-Tomić, Tatjana AU - Vidaković, Vera AU - Tešević, Vele AU - Milosavljević, Slobodan M. PY - 2017 UR - https://cherry.chem.bg.ac.rs/handle/123456789/2466 AB - Seven derivatives of pentacyclic triterpene acids (1-7) were isolated from the bark of Alnus viridis ssp. viridis using a combination of column chromatography and semipreparative HPLC. Compounds 1-3, 6, and 7 were determined to be new after spectroscopic data interpretation and were assigned as 27-hydroxyalphitolic acid derivatives (1-3), a 27-hydroxybetulinic acid derivative (6), and a 3-epi-maslinic acid derivative (7), respectively. Pentacyclic triterpenoids with a C-27 hydroxymethyl group have been found in species of the genus Alnus for the first time. These compounds were subjected to cytotoxicity testing against a number of canter cell lines. Also, selected pentacyclic triterpenoids were selected as potential inhibitors of topoisomerases I and Ha for an in silico investigation. PB - Amer Chemical Soc, Washington T2 - Journal of Natural Products T1 - Bioactive Pentacyclic Triterpene Ester Derivatives from Alnus viridis ssp viridis Bark VL - 80 IS - 5 SP - 1255 EP - 1263 DO - 10.1021/acs.jnatprod.6b00805 ER -
@article{ author = "Novaković, Miroslav M. and Nikodinović-Runić, Jasmina and Veselinović, Jovana and Ilić-Tomić, Tatjana and Vidaković, Vera and Tešević, Vele and Milosavljević, Slobodan M.", year = "2017", abstract = "Seven derivatives of pentacyclic triterpene acids (1-7) were isolated from the bark of Alnus viridis ssp. viridis using a combination of column chromatography and semipreparative HPLC. Compounds 1-3, 6, and 7 were determined to be new after spectroscopic data interpretation and were assigned as 27-hydroxyalphitolic acid derivatives (1-3), a 27-hydroxybetulinic acid derivative (6), and a 3-epi-maslinic acid derivative (7), respectively. Pentacyclic triterpenoids with a C-27 hydroxymethyl group have been found in species of the genus Alnus for the first time. These compounds were subjected to cytotoxicity testing against a number of canter cell lines. Also, selected pentacyclic triterpenoids were selected as potential inhibitors of topoisomerases I and Ha for an in silico investigation.", publisher = "Amer Chemical Soc, Washington", journal = "Journal of Natural Products", title = "Bioactive Pentacyclic Triterpene Ester Derivatives from Alnus viridis ssp viridis Bark", volume = "80", number = "5", pages = "1255-1263", doi = "10.1021/acs.jnatprod.6b00805" }
Novaković, M. M., Nikodinović-Runić, J., Veselinović, J., Ilić-Tomić, T., Vidaković, V., Tešević, V.,& Milosavljević, S. M.. (2017). Bioactive Pentacyclic Triterpene Ester Derivatives from Alnus viridis ssp viridis Bark. in Journal of Natural Products Amer Chemical Soc, Washington., 80(5), 1255-1263. https://doi.org/10.1021/acs.jnatprod.6b00805
Novaković MM, Nikodinović-Runić J, Veselinović J, Ilić-Tomić T, Vidaković V, Tešević V, Milosavljević SM. Bioactive Pentacyclic Triterpene Ester Derivatives from Alnus viridis ssp viridis Bark. in Journal of Natural Products. 2017;80(5):1255-1263. doi:10.1021/acs.jnatprod.6b00805 .
Novaković, Miroslav M., Nikodinović-Runić, Jasmina, Veselinović, Jovana, Ilić-Tomić, Tatjana, Vidaković, Vera, Tešević, Vele, Milosavljević, Slobodan M., "Bioactive Pentacyclic Triterpene Ester Derivatives from Alnus viridis ssp viridis Bark" in Journal of Natural Products, 80, no. 5 (2017):1255-1263, https://doi.org/10.1021/acs.jnatprod.6b00805 . .