Effect-directed classification of biological, biochemical and chemical profiles of 50 German beers
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Biological and biochemical fingerprints were investigated for the first time for the feasibility of effect-directed classification, and thus, to allow the choice of a distinct beer with regard to beneficial health effects. A high-performance thin-layer chromatography method was newly developed and combined with in situ effect-directed analysis for profiling 50 German beers for multipotent active compounds, and thus, their health-related potential. Discovered multipotent active zones were online eluted and characterized by high resolution mass spectrometry. For example, isoxanthohumol, iso-α-ad/n-humulone or its isomers, desdimethyl-octahydro-isocohumulone and ad/n-humulone were proven as antimicrobial compounds, isoxanthohumol as an acetylcholinesterase inhibitor, and isoxanthohumol and iso-α-ad/n-humulone or its isomers as radical scavengers. Investigating multivariate data analysis of effect-directed fingerprints for the first time, the pattern recognition and classification results ...showed the power of clustering non-alcoholic beers from other types of beer, or it showed the differentiation of dark and non-alcoholic beers. © 2018 Elsevier Ltd
Кључне речи:
Direct bioautography / Effect-directed clustering / Fingerprinting / Healthy food / Multivariate data analysis / ProfilingИзвор:
Food Chemistry, 2018, 260, 344-353Финансирање / пројекти:
- German Academic Exchange Service , Germany (DAAD, project No. 57130097).
Напомена:
- This is the peer-reviewed version of the following article: Ristivojević, P. M.; Morlock, G. E. Effect-Directed Classification of Biological, Biochemical and Chemical Profiles of 50 German Beers. Food Chemistry 2018, 260, 344–353. https://doi.org/10.1016/j.foodchem.2018.03.127
- Supplementary material: http://cherry.chem.bg.ac.rs/handle/123456789/2915
DOI: 10.1016/j.foodchem.2018.03.127
ISSN: 0308-8146
WoS: 000430886500040
Scopus: 2-s2.0-85045890559
Колекције
Институција/група
Inovacioni centar / Innovation CentreTY - JOUR AU - Ristivojević, Petar AU - Morlock, Gertrud E. PY - 2018 UR - https://cherry.chem.bg.ac.rs/handle/123456789/2914 AB - Biological and biochemical fingerprints were investigated for the first time for the feasibility of effect-directed classification, and thus, to allow the choice of a distinct beer with regard to beneficial health effects. A high-performance thin-layer chromatography method was newly developed and combined with in situ effect-directed analysis for profiling 50 German beers for multipotent active compounds, and thus, their health-related potential. Discovered multipotent active zones were online eluted and characterized by high resolution mass spectrometry. For example, isoxanthohumol, iso-α-ad/n-humulone or its isomers, desdimethyl-octahydro-isocohumulone and ad/n-humulone were proven as antimicrobial compounds, isoxanthohumol as an acetylcholinesterase inhibitor, and isoxanthohumol and iso-α-ad/n-humulone or its isomers as radical scavengers. Investigating multivariate data analysis of effect-directed fingerprints for the first time, the pattern recognition and classification results showed the power of clustering non-alcoholic beers from other types of beer, or it showed the differentiation of dark and non-alcoholic beers. © 2018 Elsevier Ltd T2 - Food Chemistry T1 - Effect-directed classification of biological, biochemical and chemical profiles of 50 German beers VL - 260 SP - 344 EP - 353 DO - 10.1016/j.foodchem.2018.03.127 ER -
@article{ author = "Ristivojević, Petar and Morlock, Gertrud E.", year = "2018", abstract = "Biological and biochemical fingerprints were investigated for the first time for the feasibility of effect-directed classification, and thus, to allow the choice of a distinct beer with regard to beneficial health effects. A high-performance thin-layer chromatography method was newly developed and combined with in situ effect-directed analysis for profiling 50 German beers for multipotent active compounds, and thus, their health-related potential. Discovered multipotent active zones were online eluted and characterized by high resolution mass spectrometry. For example, isoxanthohumol, iso-α-ad/n-humulone or its isomers, desdimethyl-octahydro-isocohumulone and ad/n-humulone were proven as antimicrobial compounds, isoxanthohumol as an acetylcholinesterase inhibitor, and isoxanthohumol and iso-α-ad/n-humulone or its isomers as radical scavengers. Investigating multivariate data analysis of effect-directed fingerprints for the first time, the pattern recognition and classification results showed the power of clustering non-alcoholic beers from other types of beer, or it showed the differentiation of dark and non-alcoholic beers. © 2018 Elsevier Ltd", journal = "Food Chemistry", title = "Effect-directed classification of biological, biochemical and chemical profiles of 50 German beers", volume = "260", pages = "344-353", doi = "10.1016/j.foodchem.2018.03.127" }
Ristivojević, P.,& Morlock, G. E.. (2018). Effect-directed classification of biological, biochemical and chemical profiles of 50 German beers. in Food Chemistry, 260, 344-353. https://doi.org/10.1016/j.foodchem.2018.03.127
Ristivojević P, Morlock GE. Effect-directed classification of biological, biochemical and chemical profiles of 50 German beers. in Food Chemistry. 2018;260:344-353. doi:10.1016/j.foodchem.2018.03.127 .
Ristivojević, Petar, Morlock, Gertrud E., "Effect-directed classification of biological, biochemical and chemical profiles of 50 German beers" in Food Chemistry, 260 (2018):344-353, https://doi.org/10.1016/j.foodchem.2018.03.127 . .