Strain differences of cadmium-induced toxicity in rats: Insight from spleen and lung immune responses
2016
Preuzimanje 🢃
Autori
Demenesku, JelenaPopov-Aleksandrov, Aleksandra
Mirkov, Ivana
Ninkov, Marina
Zolotarevski, Lidija
Kataranovski, Dragan
Brčeski, Ilija
Kataranovski, Milena
Članak u časopisu (Recenzirana verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The impact of genetic background on effects of acute i.p. cadmium administration (0.5 mg/kg and 1 mg/kg) on basic immune activity of spleen and lungs was examined in two rat strains, Albino Oxford (AO) and Dark Agouti (DA), known to react differently to chemicals. More pronounced inhibition of Concanavalin A (ConA)-induced and Interleukin (IL)-2 stimulated spleen cell proliferation as well as higher levels of nitric oxide (known to decrease cell's proliferative ability) in DA rats at 1 mg/kg, along with greater inhibition of ConA-induced Interferon (IFN-gamma)-production by total and mononuclear (MNC) spleen cells and IL-17 production by spleen MNC in DA vs. AO rats at this dose show greater susceptibility of this strain to Cd effects on spleen cells response. More pronounced infiltration of neutrophils/CD11b(+) cells to lungs of DA rats treated with 1 mg/kg of Cd and decreased IL-17 lung cell responses noted solely in DA rats speaks in favor of their higher susceptibility to this meta...l. However, lack of strain disparity in lung cells IFN-gamma responses show that there are regional differences as well. Novel data from this study depict complexity of the influence of genetic background on the effects of cadmium on host immune reactivity. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
Ključne reči:
Cadmium / Rats / Albino Oxford (AO) and Dark Agouti (DA) / strains / Spleen / LungsIzvor:
Toxicology Letters, 2016, 256, 33-43Izdavač:
- Elsevier Ireland Ltd, Clare
Finansiranje / projekti:
- Imunomodulatorni efekti ksenobiotika i biotičkih faktora životne sredine na populacije mišolikih glodara (RS-MESTD-Basic Research (BR or ON)-173039)
Napomena:
- This is peer-reviewed version of the following article: Demenesku, J.; Popov Aleksandrov, A.; Mirkov, I.; Ninkov, M.; Zolotarevski, L.; Kataranovski, D.; Brceski, I.; Kataranovski, M. Strain Differences of Cadmium-Induced Toxicity in Rats: Insight from Spleen and Lung Immune Responses. Toxicology Letters 2016, 256, 33–43. https://doi.org/10.1016/j.toxlet.2016.05.022
DOI: 10.1016/j.toxlet.2016.05.022
ISSN: 0378-4274
PubMed: 27234498
WoS: 000378049900004
Scopus: 2-s2.0-84971473046
Kolekcije
Institucija/grupa
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Demenesku, Jelena AU - Popov-Aleksandrov, Aleksandra AU - Mirkov, Ivana AU - Ninkov, Marina AU - Zolotarevski, Lidija AU - Kataranovski, Dragan AU - Brčeski, Ilija AU - Kataranovski, Milena PY - 2016 UR - https://cherry.chem.bg.ac.rs/handle/123456789/3615 AB - The impact of genetic background on effects of acute i.p. cadmium administration (0.5 mg/kg and 1 mg/kg) on basic immune activity of spleen and lungs was examined in two rat strains, Albino Oxford (AO) and Dark Agouti (DA), known to react differently to chemicals. More pronounced inhibition of Concanavalin A (ConA)-induced and Interleukin (IL)-2 stimulated spleen cell proliferation as well as higher levels of nitric oxide (known to decrease cell's proliferative ability) in DA rats at 1 mg/kg, along with greater inhibition of ConA-induced Interferon (IFN-gamma)-production by total and mononuclear (MNC) spleen cells and IL-17 production by spleen MNC in DA vs. AO rats at this dose show greater susceptibility of this strain to Cd effects on spleen cells response. More pronounced infiltration of neutrophils/CD11b(+) cells to lungs of DA rats treated with 1 mg/kg of Cd and decreased IL-17 lung cell responses noted solely in DA rats speaks in favor of their higher susceptibility to this metal. However, lack of strain disparity in lung cells IFN-gamma responses show that there are regional differences as well. Novel data from this study depict complexity of the influence of genetic background on the effects of cadmium on host immune reactivity. (C) 2016 Elsevier Ireland Ltd. All rights reserved. PB - Elsevier Ireland Ltd, Clare T2 - Toxicology Letters T1 - Strain differences of cadmium-induced toxicity in rats: Insight from spleen and lung immune responses VL - 256 SP - 33 EP - 43 DO - 10.1016/j.toxlet.2016.05.022 ER -
@article{ author = "Demenesku, Jelena and Popov-Aleksandrov, Aleksandra and Mirkov, Ivana and Ninkov, Marina and Zolotarevski, Lidija and Kataranovski, Dragan and Brčeski, Ilija and Kataranovski, Milena", year = "2016", abstract = "The impact of genetic background on effects of acute i.p. cadmium administration (0.5 mg/kg and 1 mg/kg) on basic immune activity of spleen and lungs was examined in two rat strains, Albino Oxford (AO) and Dark Agouti (DA), known to react differently to chemicals. More pronounced inhibition of Concanavalin A (ConA)-induced and Interleukin (IL)-2 stimulated spleen cell proliferation as well as higher levels of nitric oxide (known to decrease cell's proliferative ability) in DA rats at 1 mg/kg, along with greater inhibition of ConA-induced Interferon (IFN-gamma)-production by total and mononuclear (MNC) spleen cells and IL-17 production by spleen MNC in DA vs. AO rats at this dose show greater susceptibility of this strain to Cd effects on spleen cells response. More pronounced infiltration of neutrophils/CD11b(+) cells to lungs of DA rats treated with 1 mg/kg of Cd and decreased IL-17 lung cell responses noted solely in DA rats speaks in favor of their higher susceptibility to this metal. However, lack of strain disparity in lung cells IFN-gamma responses show that there are regional differences as well. Novel data from this study depict complexity of the influence of genetic background on the effects of cadmium on host immune reactivity. (C) 2016 Elsevier Ireland Ltd. All rights reserved.", publisher = "Elsevier Ireland Ltd, Clare", journal = "Toxicology Letters", title = "Strain differences of cadmium-induced toxicity in rats: Insight from spleen and lung immune responses", volume = "256", pages = "33-43", doi = "10.1016/j.toxlet.2016.05.022" }
Demenesku, J., Popov-Aleksandrov, A., Mirkov, I., Ninkov, M., Zolotarevski, L., Kataranovski, D., Brčeski, I.,& Kataranovski, M.. (2016). Strain differences of cadmium-induced toxicity in rats: Insight from spleen and lung immune responses. in Toxicology Letters Elsevier Ireland Ltd, Clare., 256, 33-43. https://doi.org/10.1016/j.toxlet.2016.05.022
Demenesku J, Popov-Aleksandrov A, Mirkov I, Ninkov M, Zolotarevski L, Kataranovski D, Brčeski I, Kataranovski M. Strain differences of cadmium-induced toxicity in rats: Insight from spleen and lung immune responses. in Toxicology Letters. 2016;256:33-43. doi:10.1016/j.toxlet.2016.05.022 .
Demenesku, Jelena, Popov-Aleksandrov, Aleksandra, Mirkov, Ivana, Ninkov, Marina, Zolotarevski, Lidija, Kataranovski, Dragan, Brčeski, Ilija, Kataranovski, Milena, "Strain differences of cadmium-induced toxicity in rats: Insight from spleen and lung immune responses" in Toxicology Letters, 256 (2016):33-43, https://doi.org/10.1016/j.toxlet.2016.05.022 . .