Green Light-Responsive CO-Releasing Polymeric Materials Derived from Ring-Opening Metathesis Polymerization
Authorized Users Only
2019
Authors
Gandra, Upendar ReddySinopoli, Alessandro
Moncho, Salvador
Nanda Kumar, Manjula
Ninković, Dragan
Zarić, Snežana D.
Sohail, Muhammad
Al-Meer, Saeed
Brothers, Edward N.
Mazloum, Nayef A.
Al-Hashimi, Mohammed
Bazzi, Hassan S.
Article (Published version)
Metadata
Show full item recordAbstract
Carbon monoxide (CO) is an important biological gasotransmitter in living cells. Precise spatial and temporal control over release of CO is a major requirement for clinical application. To date, the most reported carbon monoxide releasing materials use expensive fabrication methods and require harmful and poorly designed tissue-penetrating UV irradiation to initiate the CO release precisely at infected sites. Herein, we report the first example of utilizing a green light-responsive CO-releasing polymer P synthesized via ring-opening metathesis polymerization. Both monomer M and polymer P were very stable under dark conditions and CO release was effectively triggered using minimal power and low energy wavelength irradiation (550 nm, ≤28 mW). Time-dependent density functional theory (TD-DFT) calculations were carried out to simulate the electronic transition and insight into the nature of the excitations for both L and M. TD-DFT calculations indicate that the absorption peak of M is main...ly due to the excitation of the seventh singlet excited state, S7. Furthermore, stretchable materials using polytetrafluoroethylene (PTFE) strips based on P were fabricated to afford P-PTFE, which can be used as a simple, inexpensive, and portable CO storage bandage. Insignificant cytotoxicity as well as cell permeability was found for M and P against human embryonic kidney cells.
Keywords:
carbon monoxide (CO) / CO-releasing material (CORMat) / light-responsive / polymer conjugates / portable CO storage and CO release bandageSource:
ACS Applied Materials and Interfaces, 2019, 11, 37, 34376-34384Publisher:
- American Chemical Society
DOI: 10.1021/acsami.9b12628
ISSN: 1944-8244
WoS: 000487179900091
Scopus: 2-s2.0-85072508757
Collections
Institution/Community
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Gandra, Upendar Reddy AU - Sinopoli, Alessandro AU - Moncho, Salvador AU - Nanda Kumar, Manjula AU - Ninković, Dragan AU - Zarić, Snežana D. AU - Sohail, Muhammad AU - Al-Meer, Saeed AU - Brothers, Edward N. AU - Mazloum, Nayef A. AU - Al-Hashimi, Mohammed AU - Bazzi, Hassan S. PY - 2019 UR - https://cherry.chem.bg.ac.rs/handle/123456789/3636 AB - Carbon monoxide (CO) is an important biological gasotransmitter in living cells. Precise spatial and temporal control over release of CO is a major requirement for clinical application. To date, the most reported carbon monoxide releasing materials use expensive fabrication methods and require harmful and poorly designed tissue-penetrating UV irradiation to initiate the CO release precisely at infected sites. Herein, we report the first example of utilizing a green light-responsive CO-releasing polymer P synthesized via ring-opening metathesis polymerization. Both monomer M and polymer P were very stable under dark conditions and CO release was effectively triggered using minimal power and low energy wavelength irradiation (550 nm, ≤28 mW). Time-dependent density functional theory (TD-DFT) calculations were carried out to simulate the electronic transition and insight into the nature of the excitations for both L and M. TD-DFT calculations indicate that the absorption peak of M is mainly due to the excitation of the seventh singlet excited state, S7. Furthermore, stretchable materials using polytetrafluoroethylene (PTFE) strips based on P were fabricated to afford P-PTFE, which can be used as a simple, inexpensive, and portable CO storage bandage. Insignificant cytotoxicity as well as cell permeability was found for M and P against human embryonic kidney cells. PB - American Chemical Society T2 - ACS Applied Materials and Interfaces T1 - Green Light-Responsive CO-Releasing Polymeric Materials Derived from Ring-Opening Metathesis Polymerization VL - 11 IS - 37 SP - 34376 EP - 34384 DO - 10.1021/acsami.9b12628 ER -
@article{ author = "Gandra, Upendar Reddy and Sinopoli, Alessandro and Moncho, Salvador and Nanda Kumar, Manjula and Ninković, Dragan and Zarić, Snežana D. and Sohail, Muhammad and Al-Meer, Saeed and Brothers, Edward N. and Mazloum, Nayef A. and Al-Hashimi, Mohammed and Bazzi, Hassan S.", year = "2019", abstract = "Carbon monoxide (CO) is an important biological gasotransmitter in living cells. Precise spatial and temporal control over release of CO is a major requirement for clinical application. To date, the most reported carbon monoxide releasing materials use expensive fabrication methods and require harmful and poorly designed tissue-penetrating UV irradiation to initiate the CO release precisely at infected sites. Herein, we report the first example of utilizing a green light-responsive CO-releasing polymer P synthesized via ring-opening metathesis polymerization. Both monomer M and polymer P were very stable under dark conditions and CO release was effectively triggered using minimal power and low energy wavelength irradiation (550 nm, ≤28 mW). Time-dependent density functional theory (TD-DFT) calculations were carried out to simulate the electronic transition and insight into the nature of the excitations for both L and M. TD-DFT calculations indicate that the absorption peak of M is mainly due to the excitation of the seventh singlet excited state, S7. Furthermore, stretchable materials using polytetrafluoroethylene (PTFE) strips based on P were fabricated to afford P-PTFE, which can be used as a simple, inexpensive, and portable CO storage bandage. Insignificant cytotoxicity as well as cell permeability was found for M and P against human embryonic kidney cells.", publisher = "American Chemical Society", journal = "ACS Applied Materials and Interfaces", title = "Green Light-Responsive CO-Releasing Polymeric Materials Derived from Ring-Opening Metathesis Polymerization", volume = "11", number = "37", pages = "34376-34384", doi = "10.1021/acsami.9b12628" }
Gandra, U. R., Sinopoli, A., Moncho, S., Nanda Kumar, M., Ninković, D., Zarić, S. D., Sohail, M., Al-Meer, S., Brothers, E. N., Mazloum, N. A., Al-Hashimi, M.,& Bazzi, H. S.. (2019). Green Light-Responsive CO-Releasing Polymeric Materials Derived from Ring-Opening Metathesis Polymerization. in ACS Applied Materials and Interfaces American Chemical Society., 11(37), 34376-34384. https://doi.org/10.1021/acsami.9b12628
Gandra UR, Sinopoli A, Moncho S, Nanda Kumar M, Ninković D, Zarić SD, Sohail M, Al-Meer S, Brothers EN, Mazloum NA, Al-Hashimi M, Bazzi HS. Green Light-Responsive CO-Releasing Polymeric Materials Derived from Ring-Opening Metathesis Polymerization. in ACS Applied Materials and Interfaces. 2019;11(37):34376-34384. doi:10.1021/acsami.9b12628 .
Gandra, Upendar Reddy, Sinopoli, Alessandro, Moncho, Salvador, Nanda Kumar, Manjula, Ninković, Dragan, Zarić, Snežana D., Sohail, Muhammad, Al-Meer, Saeed, Brothers, Edward N., Mazloum, Nayef A., Al-Hashimi, Mohammed, Bazzi, Hassan S., "Green Light-Responsive CO-Releasing Polymeric Materials Derived from Ring-Opening Metathesis Polymerization" in ACS Applied Materials and Interfaces, 11, no. 37 (2019):34376-34384, https://doi.org/10.1021/acsami.9b12628 . .