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dc.creatorStojsavljević, Aleksandar
dc.creatorRovčanin, Branislav
dc.creatorJagodić, Jovana
dc.creatorDrašković Radojković, Danijela
dc.creatorPaunović, Ivan
dc.creatorGavrović-Jankulović, Marija
dc.creatorManojlović, Dragan D.
dc.date.accessioned2020-08-24T08:46:19Z
dc.date.available2020-08-24T08:46:19Z
dc.date.issued2020
dc.identifier.issn0013-9351
dc.identifier.urihttps://cherry.chem.bg.ac.rs/handle/123456789/4032
dc.description.abstractOur previous investigation showed significantly increased arsenic (As) content in thyroid tissue samples of patients with Hashimoto's thyroiditis (HT). This research aimed to extend previous findings and provide reliable insight into the close relationship between As and other trace elements with HT by considering a greater number of thyroid tissue samples, accompanied by blood and urine samples. The essential trace elements for thyroid homeostasis (Mn, Cu, Zn, Se) and the main threatening toxic trace elements (Ni, As, Pb, Cd, U) was analyzed by inductively coupled plasma-mass spectrometry (ICP-MS). Relevant parameters that could affect the concentration of trace elements were considered. This research showed that there was a difference in the elemental profile between HT and control samples. The most important findings were related to the elevated As and Pb content in the thyroid tissue and HT blood samples. The obtained negative correlations between As and Pb with Se may explain the antagonistic effect of As and Pb on the extrusion of essential Se from the HT tissue. The reduced Se content in the blood and its increased content in urine samples may further confirm this hypothesis and explain the lack of Se in HT. Furthermore, the reported results may highlight the unresolved molecular basis of HT and could indicate the role of trace element effects on thyroid homeostasis.
dc.publisherElsevier
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172030/RS//
dc.rightsrestrictedAccess
dc.sourceEnvironmental Research
dc.subjectArsenic (As)
dc.subjectHashimoto's thyroiditis
dc.subjectLead (Pb)
dc.subjectSelenium (Se)
dc.subjectToxic/ essential trace elements
dc.titleSignificance of arsenic and lead in Hashimoto's thyroiditis demonstrated on thyroid tissue, blood, and urine samples
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМанојловић, Драган Д.; Стојсављевић, Aлександар; Ровчанин, Бранислав; Јагодић, Јована; Пауновић, Иван; Драшковић Радојковић, Данијела; Гавровић-Јанкуловић, Марија;
dc.citation.volume186
dc.citation.spage109538
dc.identifier.wos000548186300069
dc.identifier.doi10.1016/j.envres.2020.109538
dc.citation.rankaM21~
dc.type.versionpublishedVersion
dc.identifier.scopus2-s2.0-85083432390


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Приказ основних података о документу