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New 4-aminoquinolines as moderate inhibitors of P. falciparum malaria
dc.creator | Opsenica, Igor | |
dc.creator | Selaković, Milica | |
dc.creator | Tot, Mikloš | |
dc.creator | Verbić, Tatjana | |
dc.creator | Srbljanović, Jelena | |
dc.creator | Štajner, Tijana | |
dc.creator | Đurković-Đaković, Olgica | |
dc.creator | Šolaja, Bogdan A. | |
dc.date.accessioned | ||
dc.date.available | ||
dc.date.issued | 2021 | |
dc.identifier.issn | 0352-5139 | |
dc.identifier.uri | https://cherry.chem.bg.ac.rs/handle/123456789/4389 | |
dc.description.abstract | Synthesis of novel aminoquinoline derivatives has been accomplished and their activity against malaria strains has been examined. The compounds showed moderate in vitro antimalarial activity against two P. falciparum strains, 3D7 (CQ susceptible clone) and Dd2 (CQ resistant clone). Three aminoquinolines were further examined for antimalarial efficacy in a mouse model using a modified Thompson test. In this model, mice were infected with P. berghei-infected red blood cells, and drugs were administered orally. Antimalarial 3 was found toxic at a dose of 320 (mg/kg)/day in 3/6 mice, however, 2/6 mice of the same group survived through day 31, and one of them was cured. © 2021 Serbian Chemical Society. All rights reserved. | |
dc.publisher | Belgrade : Serbian Chemical Society | |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200168/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200288/RS// | |
dc.relation | Serbian Academy of Sciences and Arts, project F-80 | |
dc.relation.isversionof | https://doi.org/10.2298/JSC201225005O | |
dc.relation.isreferencedby | https://cherry.chem.bg.ac.rs/handle/123456789/4392 | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | Journal of the Serbian Chemical Society | |
dc.subject | Antimalarials | |
dc.subject | Bromobenzyl derivatives | |
dc.subject | Quinoline | |
dc.subject | β-hematin inhibitory activity | |
dc.title | New 4-aminoquinolines as moderate inhibitors of P. falciparum malaria | |
dc.type | article | en |
dc.rights.license | BY-NC-ND | |
dcterms.abstract | Опсеница, Игор; Србљановић, Јелена; Селаковић, Милица; Шолаја, Богдан A.; Вербић, Татјана; Тот, Миклош; Штајнер, Тијана; Ђурковић-Ђаковић, Олгица; | |
dc.citation.volume | 86 | |
dc.citation.issue | 2 | |
dc.citation.spage | 115 | |
dc.citation.epage | 123 | |
dc.identifier.wos | 000639574500001 | |
dc.identifier.doi | 10.2298/JSC201225005O | |
dc.citation.rank | M23~ | |
dc.description.other | Supplementary material: [https://cherry.chem.bg.ac.rs/handle/123456789/4392] | |
dc.type.version | publishedVersion | |
dc.identifier.scopus | 2-s2.0-85102648212 | |
dc.identifier.fulltext | https://cherry.chem.bg.ac.rs/bitstream/id/26758/bitstream_26758.pdf |