Voltammetric determination of diazepam on antimony film screen-printed electrode in pharmaceutical formulations
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Prikaz svih podataka o dokumentuApstrakt
Background: Diazepam belongs to the group of 1,4-benzodiapines. It is used for the treatment of anxiety, convulsions and as a muscle relaxant. The presence of 4,5-azomethine group enables its electrochemical detection.Introduction: A screen-printed electrode modified with antimony film was used for the determination of diazepam in pharmaceutical preparationsMethods: Electrode modification was done by ex-situ deposition of antimony on commercially available screen-printed electrode. Parameters affecting the electroanalytical response of the sensor, such as deposition potential, deposition time, and antimony concentration, were examined and optimized. The modified electrode showed enhanced electroactivity for diazepam reduction compared to unmodified electrode. Under optimal conditions, linear sweep voltammetry was used for the determination of analyte.Results: The sensor showed linear dependence in the range from 0.5 to 10 μmol/L, the correlation coefficient was 0.9992. The limit of det...ection was 0.33 μmol/L, corresponding limit of quantification was 1.08 μmol/L. Modification enabled determination of diazepam in the presence of oxygen. Conclusion: The modified electrode was used for the determination of diazepam in tablets. Results confirmed the applicability of the electrochemical sensor.
Ključne reči:
Diazepam determination / antimony film electrode / screen-printed electrode / linear sweep voltammetryIzvor:
Current Pharmaceutical Analysis, 2021, 17, 7, 945-950Izdavač:
- Bentham Science
Finansiranje / projekti:
Napomena:
- This is the peer-reviewed version of the article: Vesna, A.; Rada, B.; Aleksandar, L. Voltammetric Determination of Diazepam on Antimony Film Screen- Printed Electrode in Pharmaceutical Formulations. Current Pharmaceutical Analysis 2021, 17 (7), 945–950. https://doi.org/10.2174/1573412916999200730234925
Povezane informacije:
- Verzija dokumenta
https://doi.org/10.2174/1573412916999200730234925 - Verzija dokumenta
https://cherry.chem.bg.ac.rs/handle/123456789/4401
DOI: 10.2174/1573412916999200730234925
ISSN: 1573-4129
WoS: 000663629400014
Scopus: 2-s2.0-85104179222
URI
https://cherry.chem.bg.ac.rs/handle/123456789/4401https://cherry.chem.bg.ac.rs/handle/123456789/4402
Kolekcije
Institucija/grupa
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Antunović, Vesna R. AU - Baošić, Rada AU - Lolić, Aleksandar PY - 2021 UR - https://cherry.chem.bg.ac.rs/handle/123456789/4401 UR - https://cherry.chem.bg.ac.rs/handle/123456789/4402 AB - Background: Diazepam belongs to the group of 1,4-benzodiapines. It is used for the treatment of anxiety, convulsions and as a muscle relaxant. The presence of 4,5-azomethine group enables its electrochemical detection.Introduction: A screen-printed electrode modified with antimony film was used for the determination of diazepam in pharmaceutical preparationsMethods: Electrode modification was done by ex-situ deposition of antimony on commercially available screen-printed electrode. Parameters affecting the electroanalytical response of the sensor, such as deposition potential, deposition time, and antimony concentration, were examined and optimized. The modified electrode showed enhanced electroactivity for diazepam reduction compared to unmodified electrode. Under optimal conditions, linear sweep voltammetry was used for the determination of analyte.Results: The sensor showed linear dependence in the range from 0.5 to 10 μmol/L, the correlation coefficient was 0.9992. The limit of detection was 0.33 μmol/L, corresponding limit of quantification was 1.08 μmol/L. Modification enabled determination of diazepam in the presence of oxygen. Conclusion: The modified electrode was used for the determination of diazepam in tablets. Results confirmed the applicability of the electrochemical sensor. PB - Bentham Science T2 - Current Pharmaceutical Analysis T1 - Voltammetric determination of diazepam on antimony film screen-printed electrode in pharmaceutical formulations VL - 17 IS - 7 SP - 945 EP - 950 DO - 10.2174/1573412916999200730234925 ER -
@article{ author = "Antunović, Vesna R. and Baošić, Rada and Lolić, Aleksandar", year = "2021", abstract = "Background: Diazepam belongs to the group of 1,4-benzodiapines. It is used for the treatment of anxiety, convulsions and as a muscle relaxant. The presence of 4,5-azomethine group enables its electrochemical detection.Introduction: A screen-printed electrode modified with antimony film was used for the determination of diazepam in pharmaceutical preparationsMethods: Electrode modification was done by ex-situ deposition of antimony on commercially available screen-printed electrode. Parameters affecting the electroanalytical response of the sensor, such as deposition potential, deposition time, and antimony concentration, were examined and optimized. The modified electrode showed enhanced electroactivity for diazepam reduction compared to unmodified electrode. Under optimal conditions, linear sweep voltammetry was used for the determination of analyte.Results: The sensor showed linear dependence in the range from 0.5 to 10 μmol/L, the correlation coefficient was 0.9992. The limit of detection was 0.33 μmol/L, corresponding limit of quantification was 1.08 μmol/L. Modification enabled determination of diazepam in the presence of oxygen. Conclusion: The modified electrode was used for the determination of diazepam in tablets. Results confirmed the applicability of the electrochemical sensor.", publisher = "Bentham Science", journal = "Current Pharmaceutical Analysis", title = "Voltammetric determination of diazepam on antimony film screen-printed electrode in pharmaceutical formulations", volume = "17", number = "7", pages = "945-950", doi = "10.2174/1573412916999200730234925" }
Antunović, V. R., Baošić, R.,& Lolić, A.. (2021). Voltammetric determination of diazepam on antimony film screen-printed electrode in pharmaceutical formulations. in Current Pharmaceutical Analysis Bentham Science., 17(7), 945-950. https://doi.org/10.2174/1573412916999200730234925
Antunović VR, Baošić R, Lolić A. Voltammetric determination of diazepam on antimony film screen-printed electrode in pharmaceutical formulations. in Current Pharmaceutical Analysis. 2021;17(7):945-950. doi:10.2174/1573412916999200730234925 .
Antunović, Vesna R., Baošić, Rada, Lolić, Aleksandar, "Voltammetric determination of diazepam on antimony film screen-printed electrode in pharmaceutical formulations" in Current Pharmaceutical Analysis, 17, no. 7 (2021):945-950, https://doi.org/10.2174/1573412916999200730234925 . .